{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T13:34:46Z","timestamp":1740144886923,"version":"3.37.3"},"reference-count":32,"publisher":"Oxford University Press (OUP)","issue":"1","license":[{"start":{"date-parts":[[1991,1,1]],"date-time":"1991-01-01T00:00:00Z","timestamp":662688000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"name":"NIH","award":["DE 04345"],"award-info":[{"award-number":["DE 04345"]}]},{"name":"Biomedical Research","award":["(S07 RR07161)"],"award-info":[{"award-number":["(S07 RR07161)"]}]},{"name":"University of Maine from the National Institutes of Health"},{"DOI":"10.13039\/100000104","name":"NASA","doi-asserted-by":"crossref","award":["NAGW-1196"],"award-info":[{"award-number":["NAGW-1196"]}],"id":[{"id":"10.13039\/100000104","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Center for Cell Research at Penn State"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[1991,1,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>A potent inhibitor of carbonic anhydrase, 5-[3-hydroxybenzoyl]thiophene-2-sulfonamide (HTS), was shown to cause a 37% reduction in the area of resorption pits formed by isolated chick osteoclasts when used at a dose of 10\u22127 M. HTS at doses of 10\u22129 and 10\u22127 M was also effective in reducing acid formation by the osteoclasts (14 and 36%, respectively). Additionally, the effect of HTS was found to be readily reversed by removing the agent, showing that it does not exert a toxic effect on the cells. This study indicates that the inhibitory effect of HTS on bone resorption is at the level of the acid-forming mechanism in osteoclasts and supports the view that carbonic anhydrase has a central role in the process.<\/jats:p>","DOI":"10.1002\/jbmr.5650060111","type":"journal-article","created":{"date-parts":[[2010,2,3]],"date-time":"2010-02-03T17:39:19Z","timestamp":1265218759000},"page":"61-66","source":"Crossref","is-referenced-by-count":23,"title":["In vitro resorptive activity of isolated chick osteoclasts: Effects of carbonic anhydrase inhibition"],"prefix":"10.1093","volume":"6","author":[{"given":"Susan J.","family":"Dr. Hunter","sequence":"first","affiliation":[{"name":"Department of Molecular and Cell Biology, Pennsylvania State University, University Park, PA 16802"},{"name":"Department of Zoology, University of Maine, Orono, ME 04469"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Clifford 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