{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,30]],"date-time":"2026-06-30T23:33:56Z","timestamp":1782862436746,"version":"3.54.5"},"reference-count":47,"publisher":"Oxford University Press (OUP)","issue":"4","license":[{"start":{"date-parts":[[1991,4,1]],"date-time":"1991-04-01T00:00:00Z","timestamp":670464000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"name":"Lederle Laboratories"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[1991,4,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>A limited, dual-photon absorptiometry, single-center study of bone mineral density (BMD) was conducted on white female glaucoma subjects who were chronic users of the carbonic anhydrase (CA) inhibitors acetazolamide (Az) or methazolamide (Mz). In postmenopausal subjects long-term (&amp;gt;4 years) CA inhibitor use was associated with a bone-sparing effect as judged by spinal BMD in comparison to controls matched for age, sex, weight, and ethnic group or in comparison to a national normative data base. Short-term (0-2 years) postmenopausal CA inhibitor users and premenopausal subjects using CA inhibitors showed no sparing of spinal BMD. Femoral neck BMD was not affected by CA inhibitor therapy in any of the groups. This study supports a proposed role for carbonic anhydrase in human bone resorption and suggests a possible future utility for carbonic anhydrase inhibitors in prophylaxis or management of primary involutional osteoporosis. Future studies are necessary to verify and expand these findings, assess the effects of CA inhibitors on bone mechanical competence, and further develop CA inhibitors with some specificity for bone.<\/jats:p>","DOI":"10.1002\/jbmr.5650060406","type":"journal-article","created":{"date-parts":[[2010,2,3]],"date-time":"2010-02-03T17:42:58Z","timestamp":1265218978000},"page":"347-354","source":"Crossref","is-referenced-by-count":38,"title":["Effect of chronic carbonic anhydrase inhibitor therapy on bone mineral density in white women"],"prefix":"10.1093","volume":"6","author":[{"suffix":"Jr.","given":"William M.","family":"Dr. Pierce","sequence":"first","affiliation":[{"name":"Department of Ophthalmology and Visual Sciences, University of Louisville, Louisville, KY 40292"},{"name":"Department of Pharmacology and Toxicology, University of Louisville, Louisville, KY 40292"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"George F.","family":"Nardin","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology and Visual Sciences, University of Louisville, Louisville, KY 40292"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Margaret F.","family":"Fuqua","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology and Visual Sciences, University of Louisville, Louisville, KY 40292"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emily","family":"Sabah-Maren","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology, University of Florida College of Medicine, Gainesville, FL 32610"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steven H.","family":"Stern","sequence":"additional","affiliation":[{"name":"Department of Medicine, University of Louisville, Louisville, KY 40292"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[1991,4,1]]},"reference":[{"key":"2024012712543409000_bib1","doi-asserted-by":"crossref","first-page":"1804","DOI":"10.1172\/JCI113523","article-title":"Age and bone mass as predictors of fracture in a prospective study","volume":"81","author":"Hui","year":"1988","journal-title":"J Clin Invest"},{"key":"2024012712543409000_bib2","doi-asserted-by":"crossref","first-page":"254","DOI":"10.1093\/oxfordjournals.aje.a114383","article-title":"Osteoporosis and the risk of hip fracture","volume":"124","author":"Melton","year":"1986","journal-title":"Am J Epidemiol"},{"key":"2024012712543409000_bib3","doi-asserted-by":"crossref","first-page":"985","DOI":"10.1016\/0895-4356(88)90036-4","article-title":"Lifetime fracture risk: An approach to hip fracture risk assessment based on bone mineral density and age","volume":"41","author":"Melton","year":"1988","journal-title":"J Clin Epidemiol"},{"key":"2024012712543409000_bib4","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1016\/0169-6009(88)90004-9","article-title":"The relation between forearm and vertebral mineral density and fractures in post-menopausal women","volume":"5","author":"Nordin","year":"1988","journal-title":"Bone Miner"},{"key":"2024012712543409000_bib5","doi-asserted-by":"crossref","first-page":"745","DOI":"10.1016\/0002-9378(85)90338-2","article-title":"Prediction of postmenopausal fracture risk with use of bone mineral measurements","volume":"153","author":"Wasnich","year":"1985","journal-title":"Am J Obstet Gynecol"},{"key":"2024012712543409000_bib6","doi-asserted-by":"crossref","first-page":"262","DOI":"10.1097\/00003086-198703000-00040","article-title":"Selection of the optimal skeletal site for fracture risk prediction","volume":"216","author":"Wasnich","year":"1987","journal-title":"Clin Orthop"},{"key":"2024012712543409000_bib7","doi-asserted-by":"crossref","first-page":"258","DOI":"10.3181\/00379727-191-42917","article-title":"Osteoporosis - 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