{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,13]],"date-time":"2025-09-13T16:17:29Z","timestamp":1757780249768,"version":"3.37.3"},"reference-count":28,"publisher":"Oxford University Press (OUP)","issue":"5","license":[{"start":{"date-parts":[[1991,5,1]],"date-time":"1991-05-01T00:00:00Z","timestamp":673056000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"DOI":"10.13039\/501100004937","name":"Bundesministerium fuer forschung und Technologie","doi-asserted-by":"crossref","award":["D 5300"],"award-info":[{"award-number":["D 5300"]}],"id":[{"id":"10.13039\/501100004937","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"crossref","award":["D 5300"],"award-info":[{"award-number":["D 5300"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[1991,5,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>The noncollagenous proteins osteonectin, bone sialoprotein, osteocalcin, the small proteoglycan decorin (PG II), and \u03b12-HS glycoprotein (which is synthesized in the liver but highly concentrated in bone) were measured in extracts of cortical bone from 3 type I, 2 type II, 8 type III and 13 type IV patients with osteogenesis imperfecta (OI) and from 7 control subjects.<\/jats:p>\n               <jats:p>Osteonectin was found to be reduced in the bone of all OI patients. The bone from severely affected type III OI patients contained the lowest levels of osteonectin. In contrast, bone sialoprotein was found to be elevated in the bones of OI patients. The highest levels were found in individuals classified as type IV patients. Osteocalcin and \u03b12-HS glycoprotein concentrations were increased in all OI patients. Decorin levels were not significantly altered in OI bones compared to controls.<\/jats:p>\n               <jats:p>These changes in the concentrations of the noncollagenous proteins may contribute to the fragility of the OI bone by interfering with complete mineralization and\/or normal tissue architecture.<\/jats:p>","DOI":"10.1002\/jbmr.5650060512","type":"journal-article","created":{"date-parts":[[2010,2,3]],"date-time":"2010-02-03T17:43:22Z","timestamp":1265219002000},"page":"501-505","source":"Crossref","is-referenced-by-count":66,"title":["Osteogenesis imperfecta: Changes in noncollagenous proteins in bone"],"prefix":"10.1093","volume":"6","author":[{"given":"U.","family":"Vetter","sequence":"first","affiliation":[{"name":"National Institutes of Health, National Institute of Dental Research, Bone Research Branch, Bldg. 30, Rm. 106, Bethesda, MD 20892"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L.W.","family":"Fisher","sequence":"additional","affiliation":[{"name":"National Institutes of Health, National Institute of Dental Research, Bone Research Branch, Bldg. 30, Rm. 106, Bethesda, MD 20892"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K.P.","family":"Mintz","sequence":"additional","affiliation":[{"name":"National Institutes of Health, National Institute of Dental Research, Bone Research Branch, Bldg. 30, Rm. 106, Bethesda, MD 20892"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.B.","family":"Kopp","sequence":"additional","affiliation":[{"name":"National Institutes of Health, National Institute of Dental Research, Bone Research Branch, Bldg. 30, Rm. 106, Bethesda, MD 20892"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"N.","family":"Tuross","sequence":"additional","affiliation":[{"name":"National Institutes of Health, National Institute of Dental Research, Bone Research Branch, Bldg. 30, Rm. 106, Bethesda, MD 20892"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.D.","family":"Termine","sequence":"additional","affiliation":[{"name":"National Institutes of Health, National Institute of Dental Research, Bone Research Branch, Bldg. 30, Rm. 106, Bethesda, MD 20892"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P. 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