{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,23]],"date-time":"2026-02-23T11:02:33Z","timestamp":1771844553233,"version":"3.50.1"},"reference-count":15,"publisher":"Oxford University Press (OUP)","issue":"11","license":[{"start":{"date-parts":[[1991,11,1]],"date-time":"1991-11-01T00:00:00Z","timestamp":688953600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"name":"Gist Brocades Pharma"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[1991,11,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Fluoride is able to augment cancellous bone mass in vertebral osteoporosis but is responsible for osteoarticular side effects in which microfractures are thought to be involved. During healing of these microfractures, a callus is formed all around the cancellous fracture line. Our hypothesis is that in fluoride-treated osteoporotic patients, calluses are bone sites where fluoride is focally deposited at a high concentration, and this could induce a local defect of calcification with a poor healing of microfractures. Our aim was to validate this hypothesis on several calluses following microfractures in undecalcified iliac cancellous bone from six women with osteoporosis (four fluoride treated and two untreated). Histologically normal iliac cancellous bone tissue, taken from a subject having neither fluoride treatment nor microfracture, was also examined. Selected areas, including new woven bone (calluses) and old lamellar bone, were carbon-coated and analyzed using an electron microprobe. Fluoride K\u03b1 and calcium K\u03b1 radiations were detected with wavelength and energy-dispersive spectrometers, respectively. In old lamellar bone at a distance from microfractures, the fluoride level was similar in normal and untreated osteoporotic patients but was slightly increased in treated osteoporotic patients. In untreated osteoporotic patients, the fluoride level was slightly higher (about 1.2 times) at the site of microfractures (lamellar and woven bone) than in lamellar bone far from such fractures, but fluoride was homogeneously distributed in lamellar and woven bone. In contrast, in treated osteoporotic patients, fluoride content was much higher (about 1.7 times) at the site of microfractures (lamellar and woven bone) than in lamellar bone far from fractures, but fluoride was heterogeneously distributed within the calluses, with the highest level in woven bone and the smallest in adjacent lamellar bone. The present data demonstrate that fluoride is preferentially concentrated in calluses of cancellous microfractures in fluoride-treated osteoporotic patients. It is likely but remains to be proven that this focal increase in fluoride uptake compromises the healing of microfractures.<\/jats:p>","DOI":"10.1002\/jbmr.5650061107","type":"journal-article","created":{"date-parts":[[2010,2,3]],"date-time":"2010-02-03T17:40:41Z","timestamp":1265218841000},"page":"1183-1190","source":"Crossref","is-referenced-by-count":16,"title":["X-ray microanalysis of fluoride distribution in microfracture calluses in cancellous iliac bone from osteoporotic patients treated with fluoride and untreated"],"prefix":"10.1093","volume":"6","author":[{"given":"Georges","family":"Boivin","sequence":"first","affiliation":[{"name":"INSERM Unit\u00e9 234, Facult\u00e9 A. Carrel, Lyon, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Brigitte","family":"Grousson","sequence":"additional","affiliation":[{"name":"CMEABG, Universit\u00e9 Claude Bernard-Lyon I, Villeurbanne, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pierre J.","family":"Meunier","sequence":"additional","affiliation":[{"name":"INSERM Unit\u00e9 234, Facult\u00e9 A. Carrel, Lyon, France"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[1991,11,1]]},"reference":[{"key":"2024012712550085700_bib1","first-page":"824","volume-title":"Osteoporosis","author":"Meunier","year":"1987"},{"key":"2024012712550085700_bib2","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1016\/8756-3282(89)90004-5","article-title":"Skeletal fluorosis: Histomorphometric analysis of bone changes and bone fluoride content in 29 patients","volume":"10","author":"Boivin","year":"1989","journal-title":"Bone"},{"key":"2024012712550085700_bib3","doi-asserted-by":"crossref","first-page":"446","DOI":"10.1056\/NEJM198202253060802","article-title":"Effect of the fluoride\/calcium regimen on vertebral fracture occurrence in postmenopausal osteoporosis: Comparison with conventional therapy","volume":"306","author":"Riggs","year":"1982","journal-title":"N Engl J 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osteoporosis","volume":"7","author":"Schnitzler","year":"1986","journal-title":"Bone"},{"key":"2024012712550085700_bib7","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1002\/jbmr.5650050207","article-title":"Iliac bone biopsies at the time of periarticular stress fractures during fluoride therapy: Comparison with pretreatment biopsies","volume":"5","author":"Schnitzler","year":"1990","journal-title":"J Bone Miner Res"},{"key":"2024012712550085700_bib8","doi-asserted-by":"crossref","first-page":"268","DOI":"10.1097\/00003086-199012000-00032","article-title":"Bone fragility of the peripheral skeleton during fluoride therapy for osteoporosis","volume":"261","author":"Schnitzler","year":"1990","journal-title":"Clin Orthop"},{"key":"2024012712550085700_bib9","first-page":"262","volume-title":"Osteoporosis","author":"Einhorn","year":"1987"},{"key":"2024012712550085700_bib10","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1179\/his.1989.12.1.23","article-title":"Electron 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