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Results revealed qualitative and quantitative differencs among the bisphosphonates tested. With Cl2MDP and APD fractional inhibition of resorption (measured as 45Ca release) in the presence of PTH was proportional to that obtained in its absence. In contrast, Me2APD, which is the most potent inhibitor of the three, was found at low concentrations (\u22645 \u00d7 10\u22127 M) to enhance the PTH-stimulated osteoclastic resorption. APD as well, at concentrations that could not inhibit resorption, had a similar effect, but Cl2MDP did not. These studies describe a new phenomenon, that low doses of nitrogen-containing bisphosphonates can act synergistically with PTH and enhance osteoclastic resorption. These findings may have clinical implications in the management of patients with increased osteoclastic resorption due to parathyroid overactivity.<\/jats:p>","DOI":"10.1002\/jbmr.5650061110","type":"journal-article","created":{"date-parts":[[2010,2,3]],"date-time":"2010-02-03T12:40:41Z","timestamp":1265200841000},"page":"1203-1210","source":"Crossref","is-referenced-by-count":22,"title":["Modulation of PTH-stimulated osteoclastic resorption by bisphosphonates in fetal mouse bone explants"],"prefix":"10.1093","volume":"6","author":[{"given":"Gabri","family":"Dr. van der Pluijm","sequence":"first","affiliation":[{"name":"Department of Endocrinology, University Hospital, Leiden, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Clemens W.G.M.","family":"L\u00f6wik","sequence":"additional","affiliation":[{"name":"Department of Endocrinology, University Hospital, Leiden, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Henny","family":"de Groot","sequence":"additional","affiliation":[{"name":"Department of Endocrinology, University Hospital, Leiden, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marcel J.","family":"Alblas","sequence":"additional","affiliation":[{"name":"Department of Endocrinology, University Hospital, Leiden, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lianne J. 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