{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T13:34:46Z","timestamp":1740144886965,"version":"3.37.3"},"reference-count":26,"publisher":"Oxford University Press (OUP)","issue":"12","license":[{"start":{"date-parts":[[1991,12,1]],"date-time":"1991-12-01T00:00:00Z","timestamp":691545600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"DOI":"10.13039\/100008392","name":"Danish Medical Research Council","doi-asserted-by":"crossref","id":[{"id":"10.13039\/100008392","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Institute for Clinical Experimental Research"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[1991,12,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Estrogen stimulates osteoblastic collagen production in vitro, but whether the same stimulation takes place in vivo is still unknown. To test the stimulatory effects of a combined estrogen-gestagen regimen in vivo we monitored serum levels of the carboxy-terminal propeptide of human type I procollagen (S-PICP) in a group of 12 osteoporotic women over a 150 week treatment period. Spinal bone mineral content (BMC) increased to a maximum of 5% over pretreatment values around week 90. Serum alkaline phosphatase (S-AP) and serum bone gla protein (S-BGP) both fell from initial values of 220 U\/liter and 39 ng\/ml, respectively, to 146 U\/liter (p &amp;lt; 0.01) and 27.2 ng\/ml (NS) around week 60 and remained reduced over the remaining treatment period. S-PICP also fell from 117 to 68 \u03bcg\/liter at week 60 and 70 \u03bcg\/ml at week 150 (P &amp;lt; 0.01). This is equal to a reduction to 32 \u00b1 10% pretreatment levels. The reduction in S-PICP was not significantly different from that of the other two markers of bone formation (S-AP and S-BGP). Thus, provided the metabolic clearance of PICP remains unaltered after hormone replacement therapy, no major stimulation of osteoblastic collagen type I synthesis was demonstrable during estrogen-gestagen treatment in this population of osteoporotic women. The changes in bone markers seen in this study are therefore consistent with an estrogen-mediated reduction in the frequency of remodeling activation. Because of the reduction in bone turnover and methodologic limitations of bone marker assays, however, smaller increases in the amount of bone formed per activation could remain undetectable.<\/jats:p>","DOI":"10.1002\/jbmr.5650061205","type":"journal-article","created":{"date-parts":[[2010,2,3]],"date-time":"2010-02-03T17:41:12Z","timestamp":1265218872000},"page":"1295-1300","source":"Crossref","is-referenced-by-count":21,"title":["Effects of a combined estrogen-gestagen regimen on serum levels of the carboxy-terminal propeptide of human type I procollagen in osteoporosis"],"prefix":"10.1093","volume":"6","author":[{"given":"Claus","family":"Hasling","sequence":"first","affiliation":[{"name":"Aarhus Bone and Mineral Research Group, University Department of Endocrinology and Metabolism, Aarhus Amtssygehus, Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Erik F.","family":"Eriksen","sequence":"additional","affiliation":[{"name":"Aarhus Bone and Mineral Research Group, University Department of Endocrinology and Metabolism, Aarhus Amtssygehus, Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jukka","family":"Melkko","sequence":"additional","affiliation":[{"name":"Collagen Research Unit, Departments of Medical Biochemistry and Clinical Chemistry, University of Oulu, Finland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Leila","family":"Risteli","sequence":"additional","affiliation":[{"name":"Collagen Research Unit, Departments of Medical Biochemistry and Clinical Chemistry, University of Oulu, Finland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peder","family":"Charles","sequence":"additional","affiliation":[{"name":"Aarhus Bone and Mineral Research Group, University Department of Endocrinology and Metabolism, Aarhus Amtssygehus, Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Leif","family":"Mosekilde","sequence":"additional","affiliation":[{"name":"Aarhus Bone and Mineral Research Group, University Department of Endocrinology and Metabolism, Aarhus Amtssygehus, Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Juha","family":"Risteli","sequence":"additional","affiliation":[{"name":"Collagen Research Unit, Departments of Medical Biochemistry and Clinical Chemistry, University of Oulu, Finland"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[1991,12,1]]},"reference":[{"key":"2024012712575217800_bib1","doi-asserted-by":"crossref","first-page":"789","DOI":"10.1136\/bmj.2.6090.789","article-title":"Prospective trial of estrogen and calcium in posmenopausal women","volume":"2","author":"Horsman","year":"1977","journal-title":"Br Med J"},{"key":"2024012712575217800_bib2","doi-asserted-by":"crossref","first-page":"1151","DOI":"10.1016\/S0140-6736(80)92592-1","article-title":"Prevention of spinal osteoporosis in oophorectomized 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