{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T11:57:53Z","timestamp":1790423873405,"version":"4.1.0"},"reference-count":32,"publisher":"Oxford University Press (OUP)","issue":"12","license":[{"start":{"date-parts":[[1991,12,1]],"date-time":"1991-12-01T00:00:00Z","timestamp":691545600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"name":"NIH","award":["PO1-AG07542-04"],"award-info":[{"award-number":["PO1-AG07542-04"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[1991,12,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>We have devised a new method for measurement of final depth of erosion in cancellous bone with an intra-individual precision of 4.3% and applied it to determine the mechanism of continuing reduction in trabecular thickness after menopause. Mean erosion depth (SD) was 40.8 (2.0) \u03bcm in 10 healthy postmenopausal women and 41.4 (2.1) \u03bcm in 10 age-matched patients with postmenopausal osteoporosis; the difference was not statistically significant. In contrast, wall thickness, using a method based on density differences between new and old bone, was 39.5 (2.0) \u03bcm in the normal subjects and 35.3 (2.0) \u03bcm in the patients with osteoporosis (p &amp;lt; 0.0001). The balance per remodeling cycle (\u0394BMU) was \u22121.34 (2.49) \u03bcm in the normal subjects and \u22126.11 (1.95) \u03bcm in the patients with osteoporosis. This difference was also highly significant (p &amp;lt; 0.001). Indirect estimations of erosion depth and \u0394BMU, based on the fall in trabecular thickness from an assumed premenopausal value of 147 \u03bcm and the number of remodeling cycles accumulated since menopause, agreed closely with the measured values. Erosion depth measured by the Eriksen method also showed no significant difference between the two groups, but because the values were substantially higher \u0394BMU was improbably high in both groups, did not differ significantly between groups, and was inconsistent with the observed difference in trabecular thickness. We conclude that (1) the more rapid continuing loss of cancellous bone in patients with postmenopausal osteoporosis than in age-matched control subjects is due entirely to a difference in wall thickness, not to a difference in erosion depth; and (2) defective recruitment and\/or function of osteoblasts is the major cellular mechanism of trabecular thinning in patients with postmenopausal osteoporosis and probably also in normal subjects. We emphasize that these conclusions do not speak to the mechanism of complete removal of trabeculae in the early years after menopause.<\/jats:p>","DOI":"10.1002\/jbmr.5650061210","type":"journal-article","created":{"date-parts":[[2010,2,3]],"date-time":"2010-02-03T17:41:12Z","timestamp":1265218872000},"page":"1331-1338","source":"Crossref","is-referenced-by-count":80,"title":["A new method for measuring cancellous bone erosion depth: Application to the cellular mechanisms of bone loss in postmenopausal osteoporosis"],"prefix":"10.1093","volume":"6","author":[{"given":"Martine E.","family":"Cohen-Solal","sequence":"first","affiliation":[{"name":"Inserm Unit\u00e9 18, Paris, France"},{"name":"Bone and Mineral Research Laboratory, Henry Ford Hospital, Detroit, Michigan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mei-Shu","family":"Shih","sequence":"additional","affiliation":[{"name":"Bone and Mineral Research Laboratory, Henry Ford Hospital, Detroit, 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