{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,7]],"date-time":"2026-02-07T22:29:13Z","timestamp":1770503353492,"version":"3.49.0"},"reference-count":35,"publisher":"Oxford University Press (OUP)","issue":"4","license":[{"start":{"date-parts":[[1992,4,1]],"date-time":"1992-04-01T00:00:00Z","timestamp":702086400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[1992,4,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Agents that exert anabolic effects on bone have generally been tested in young or estrogen-replete animals. It is unclear whether these agents exert similar effects in older ovariectomized (Ovx) animals. In this single study we examined the effects of intermittent (daily) human PTH-(1\u201334) and continuous infusion of human recombinant IGF-I alone and in combination on bone resorption and formation over a 14 day period in an aged Ovx rat model of postmenopausal osteoporosis (2-year-old rats, Ovx at 1 year). Compared to Ovx controls, PTH treatment increased bone mineral content (BMC) and bone volume and stimulated bone formation but had no effect on bone resorption. In contrast, IGF-I treatment reduced BMC and stimulated resorptive activity as assessed by increases in marrow volume, cortical porosity, osteoclast-positive eroded surfaces, and urinary hydroxyproline excretion. IGF-I had no effect on bone formation, but when combined with PTH, IGF-I blunted the response to PTH on the periosteal and endocortical surfaces. In summary, PTH stimulated bone formation in a manner similar to that observed in younger animals and IGF-I stimulated bone resorption rather than formation and blunted the bone-forming response to PTH. The effects of IGF-I in older Ovx rats may differ from those observed in younger estrogen-replete animals.<\/jats:p>","DOI":"10.1002\/jbmr.5650070410","type":"journal-article","created":{"date-parts":[[2010,2,3]],"date-time":"2010-02-03T17:07:00Z","timestamp":1265216820000},"page":"425-432","source":"Crossref","is-referenced-by-count":102,"title":["Contrasting effects of parathyroid hormone and insulin-like growth factor I in an aged ovariectomized rat model of postmenopausal osteoporosis"],"prefix":"10.1093","volume":"7","author":[{"given":"Kenneth J.","family":"Ibbotson","sequence":"first","affiliation":[{"name":"Bone Metabolism Department, Norwich Eaton Pharmaceuticals, Inc., (Procter & Gamble Company), Norwich, New York"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christopher M.","family":"Orcutt","sequence":"additional","affiliation":[{"name":"Bone Metabolism Department, Norwich Eaton Pharmaceuticals, Inc., (Procter & Gamble Company), Norwich, New York"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sharyn M.","family":"D'Souza","sequence":"additional","affiliation":[{"name":"Bone Metabolism Department, Norwich Eaton Pharmaceuticals, Inc., (Procter & Gamble Company), Norwich, New York"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carol L.","family":"Paddock","sequence":"additional","affiliation":[{"name":"Bone Metabolism Department, Norwich Eaton Pharmaceuticals, Inc., (Procter & Gamble Company), Norwich, New York"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jay A.","family":"Arthur","sequence":"additional","affiliation":[{"name":"Bone Metabolism Department, Norwich Eaton Pharmaceuticals, Inc., (Procter & Gamble Company), Norwich, New York"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maryann L.","family":"Jankowsky","sequence":"additional","affiliation":[{"name":"Bone Metabolism Department, Norwich Eaton Pharmaceuticals, Inc., (Procter & Gamble Company), 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