{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T13:34:46Z","timestamp":1740144886220,"version":"3.37.3"},"reference-count":22,"publisher":"Oxford University Press (OUP)","issue":"9","license":[{"start":{"date-parts":[[1992,9,1]],"date-time":"1992-09-01T00:00:00Z","timestamp":715305600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"name":"British Heart and Mason Medical Research Foundations"},{"DOI":"10.13039\/501100000275","name":"Leverhulme Trust","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100000275","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Oliver Bird Fund"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[1992,9,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Amylin (also known as islet amyloid polypeptide and diabetes-associated peptide) has recently been shown by us to have a potent hypocalcemic effect in rat and rabbit owing to inhibition of osteoclast-mediated bone resorption. The hypocalcemic potency of amylin was found to be second only to that of calcitonin (CT) and is 100-fold more potent than calcitonin gene-related peptide. Here we demonstrate that amylin has a hypocalcemic effect in patients with Paget's disease of bone. Both human CT (hCT) and amylin induced a maximum hypocalcemic effect 2 h following intravenous administration of the peptides (p &amp;lt; 0.001). Although on a molar basis amylin is less potent than CT, it exhibits a significantly prolonged hypocalcemic effect compared to hCT. Here we demonstrate for the first time a profound hypocalcemic effect of amylin in the human, despite sharing only 15% amino acid sequence identity with hCT.<\/jats:p>","DOI":"10.1002\/jbmr.5650070915","type":"journal-article","created":{"date-parts":[[2010,2,3]],"date-time":"2010-02-03T17:09:36Z","timestamp":1265216976000},"page":"1113-1116","source":"Crossref","is-referenced-by-count":17,"title":["Rapid publication: Hypocalcemic actions of amylin amide in humans"],"prefix":"10.1093","volume":"7","author":[{"given":"Sunil J.","family":"Wimalawansa","sequence":"first","affiliation":[{"name":"Department of Medicine, Biochemical Endocrinology Unit, Royal Postgraduate Medical School, London, England"},{"name":"Department of Chemical Pathology, Biochemical Endocrinology Unit, Royal Postgraduate Medical School, London, England"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ranjan D.","family":"Gunasekera","sequence":"additional","affiliation":[{"name":"Department of Chemical Pathology, Biochemical Endocrinology Unit, Royal Postgraduate Medical School, London, England"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Harish K.","family":"Datta","sequence":"additional","affiliation":[{"name":"Department of Chemical Pathology, Biochemical Endocrinology Unit, Royal Postgraduate Medical School, London, England"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[1992,9,1]]},"reference":[{"key":"2024013112175316600_bib1","doi-asserted-by":"crossref","first-page":"471","DOI":"10.1016\/S0140-6736(67)90897-5","article-title":"Thyrocalcitonin in Paget's disease","volume":"2","author":"Bijvoet","year":"1967","journal-title":"Lancet"},{"key":"2024013112175316600_bib2","first-page":"86","article-title":"Human calcitonin treatment of Paget's disease of bone","volume":"127","author":"Singer","year":"1977","journal-title":"Clin 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