{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,8]],"date-time":"2026-04-08T17:43:30Z","timestamp":1775670210554,"version":"3.50.1"},"reference-count":15,"publisher":"Oxford University Press (OUP)","issue":"12","license":[{"start":{"date-parts":[[1992,12,1]],"date-time":"1992-12-01T00:00:00Z","timestamp":723168000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[1992,12,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>A group of 26 patients aged 47\u201381 years (average 67) with spinal osteoporosis and back pain for more than 6 months were investigated with planar and SPECT bone scintigraphy and anterior and lateral x-rays of the thoracolumbar spine. Abnormal activity on bone scintigraphy was found in all patients, of whom 22 had multiple lesions. A total of 17 (65%) patients had abnormal activity associated with collapsed vertebral bodies, 5 (19%) had degenerative disk disease, and 21 (81%) had facetal joint disease. Of 112 lesions identified by SPECT, 60 (54%) were localized to the apophyseal joints. Facetal lesions were commoner in those patients with more collapsed vertebrae, and 32 facetal lesions (54%) were associated with collapse of the vertebra immediately above or below. Bone scintigraphy findings suggest that in some individuals with osteoporosis and chronic back pain, collapse of the vertebral body or degenerative disk disease are causes of pain. However, the high frequency of increased apophyseal joint activity suggests that the facet joints may also be an important site of origin of pain in these individuals. Bone scintigraphy may identify a subgroup of osteoporotic patients with chronic back pain who would benefit from treatment to the facet joints.<\/jats:p>","DOI":"10.1002\/jbmr.5650071213","type":"journal-article","created":{"date-parts":[[2010,2,3]],"date-time":"2010-02-03T16:54:57Z","timestamp":1265216097000},"page":"1455-1460","source":"Crossref","is-referenced-by-count":52,"title":["Osteoporosis and chronic back pain: A study with single-photon emission computed tomography bone scintigraphy"],"prefix":"10.1093","volume":"7","author":[{"given":"P.J.","family":"Dr. Ryan","sequence":"first","affiliation":[{"name":"Department of Rheumatology, Guy's Hospital, London, England"},{"name":"Department of Nuclear Medicine, Guy's Hospital, London, England"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P.","family":"Evans","sequence":"additional","affiliation":[{"name":"Department of Nuclear Medicine, Guy's Hospital, London, England"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"T.","family":"Gibson","sequence":"additional","affiliation":[{"name":"Department of Rheumatology, Guy's Hospital, London, England"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"I.","family":"Fogelman","sequence":"additional","affiliation":[{"name":"Department of Nuclear Medicine, Guy's Hospital, London, England"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[1992,12,1]]},"reference":[{"issue":"2","key":"2024013112194734900_bib1","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1007\/BF02207237","article-title":"The natural history of the osteoporotic vertebral fracture","volume":"8","author":"Lyritis","year":"1989","journal-title":"Clin Rheumatol"},{"key":"2024013112194734900_bib2","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1016\/0169-6009(90)90107-Q","article-title":"A study of complaints and their relation to vertebral destruction in patients with osteoporosis","volume":"8","author":"Leidig","year":"1990","journal-title":"Bone Miner"},{"key":"2024013112194734900_bib3","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1007\/BF01625442","article-title":"Evaluation of adverse health outcomes associated with vertebral fractures","volume":"1","author":"Ross","year":"1991","journal-title":"Osteoporosis Int"},{"key":"2024013112194734900_bib4","doi-asserted-by":"crossref","first-page":"783","DOI":"10.1097\/00007632-199008010-00009","article-title":"Osteoporosis and back pain in the elderly. A controlled epidemiologic and radiographic study","volume":"15","author":"Zetterberg","year":"1990","journal-title":"Spine"},{"key":"2024013112194734900_bib5","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1136\/ard.50.3.162","article-title":"A longitudinal study of back pain and radiological changes in the lumbar spine of middle aged women. 11. Radiographic findings","volume":"50","author":"Symmons","year":"1991","journal-title":"Ann Rheum Dis"},{"key":"2024013112194734900_bib6","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1007\/BF01627079","article-title":"Screening for vertebral osteoporosis using individual risk factors","volume":"2","author":"Copper","year":"1991","journal-title":"Osteoporosis Int"},{"key":"2024013112194734900_bib7","first-page":"629","article-title":"Nuclear medicine studies of aging. VI. Dual photon absorptiometry and bone scans in \u201cat risk\u201d women with back pain","volume":"15","author":"Gupta","year":"1988","journal-title":"Nucl Med Biol"},{"key":"2024013112194734900_bib8","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1016\/S0001-2998(87)80037-5","article-title":"Bone SPECT","volume":"17","author":"Collier","year":"1987","journal-title":"Semin Nucl Med"},{"key":"2024013112194734900_bib9","doi-asserted-by":"crossref","first-page":"849","DOI":"10.1148\/radiology.182.3.1531544","article-title":"Chronic low back pain: Comparison of bone SPECT with radiography and CT","volume":"182","author":"Ryan","year":"1992","journal-title":"Radiology"},{"key":"2024013112194734900_bib10","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1002\/jbmr.5650060302","article-title":"Classification of vertebral fractures","volume":"6","author":"Eastell","year":"1991","journal-title":"J Bone Miner Res"},{"key":"2024013112194734900_bib11","article-title":"Diagnosis of facet joint arthritis in patients with low back pain \u2014 comparison of SPECT and planar bone scintigraphy and facet joint injection (abstract)","volume":"84","author":"Scott","year":"1991","journal-title":"Aust N Z Soc Nucl Med"},{"key":"2024013112194734900_bib12","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1148\/radiology.134.1.7350594","article-title":"Computed tomography of the lumbar facet joints","volume":"134","author":"Carrera","year":"1980","journal-title":"Radiology"},{"key":"2024013112194734900_bib13","article-title":"Bone scintigraphy with SPECT in low back pain (abstract)","volume":"236","author":"Ryan","year":"1991","journal-title":"Eur Cong Rheumatol"},{"key":"2024013112194734900_bib14","doi-asserted-by":"crossref","first-page":"1002","DOI":"10.1056\/NEJM199110033251405","article-title":"A controlled trial of corticosteroid injections into facet joints for chronic low back pain","volume":"325","author":"Carrette","year":"1991","journal-title":"N Engl J Med"},{"key":"2024013112194734900_bib15","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1097\/00006231-199206000-00030","article-title":"Facet joint injection in patients with low back pain and increased facetal activity on bone scintigraphy with SPECT: A pilot study (abstract)","volume":"13","author":"Ryan","year":"1992","journal-title":"Nucl Med Commun"}],"container-title":["Journal of Bone and Mineral Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fjbmr.5650071213","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/academic.oup.com\/jbmr\/article-pdf\/7\/12\/1455\/56487629\/5650071213.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/jbmr\/article-pdf\/7\/12\/1455\/56487629\/5650071213.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,3,13]],"date-time":"2024-03-13T14:55:12Z","timestamp":1710341712000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/jbmr\/article\/7\/12\/1455-1460\/7500290"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1992,12,1]]},"references-count":15,"journal-issue":{"issue":"12","published-online":{"date-parts":[[1992,12,1]]},"published-print":{"date-parts":[[1992,12,1]]}},"URL":"https:\/\/doi.org\/10.1002\/jbmr.5650071213","relation":{},"ISSN":["0884-0431","1523-4681"],"issn-type":[{"value":"0884-0431","type":"print"},{"value":"1523-4681","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[1992,12,1]]},"published":{"date-parts":[[1992,12,1]]}}}