{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T07:08:16Z","timestamp":1790060896945,"version":"4.0.1"},"reference-count":46,"publisher":"Oxford University Press (OUP)","issue":"4","license":[{"start":{"date-parts":[[1993,4,1]],"date-time":"1993-04-01T00:00:00Z","timestamp":733622400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"DOI":"10.13039\/501100000274","name":"British Heart Foundation","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100000274","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100000275","name":"Leverhulme Trust","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100000275","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[1993,4,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>The Quantitative Analysis Of Immunoreactive Calcitonin (Ict) Is The Assay Of Choice For Diagnosis And Follow-Up Of Patients With Medullary Thryoid Carcinoma (Mtc). However, In A Small Percentage Of Patients With Mtc Or C Cell Hyperplasia (Cch), Basal And Stimulated Ict Levels May Not Be Significantly Elevated. In These Patients, Calcitonin Gene-Related Peptide (Cgrp) Radioreceptor Assay (Rra) Can Be Used Complementary To Immunoassay For Ct (Or Katacalcin) For Prompt Diagnosis Of Mtc And Cch. Cgrp Rra Is A Robust, Rapid, Sensitive, And Specific Determinant Of \u201cReceptor-Recognized\u201d Cgrp (Rr-Cgrp; Intact Molecule Of Cgrp) Either In Plasma Or In Tissue Extracts. Plasma Rr-Cgrp Levels Rose &amp;gt; 100% 2\u20135 Minutes After Stimulation With Intravenous Pentagastrin (Calcium Or Oral Alcohol) (P &amp;lt; 0.001), Whereas Icgrp Levels Were Raised To A Lesser Degree (P &amp;lt; 0.01). In Six Patients Who Had A False Positive Ict Response After Pentagastrin Or Had Raised Basal Ict Levels Measured With A Two-Site Immunoradiometric Assay, Rr-Cgrp Showed Only A Minimal Change. On The Other Hand, In Patients With Cch (True Positive, N = 8), Ict Was Increased By Only 40% After Pentagastrin But Rr-Cgrp Levels Rose By 140% (P &amp;lt; 0.001). No Change In Ict Or Rr-Cgrp Levels In Plasma Were Detected In Healthy Normal Volunteers After Administration Of Pentagastrin. Therefore, In Addition To The Plasma Ict Levels, Rr-Cgrp Would Resolve Some Of The Difficult Diagnostic Problems Associated With Mtc And Likely Improve The Specificity And Sensitivity Of Identifying Cch.<\/jats:p>","DOI":"10.1002\/jbmr.5650080411","type":"journal-article","created":{"date-parts":[[2010,2,3]],"date-time":"2010-02-03T16:47:47Z","timestamp":1265215667000},"page":"467-473","source":"Crossref","is-referenced-by-count":8,"title":["CGRP Radioreceptor assay: A new diagnostic tool for medullary thyroid carcinoma"],"prefix":"10.1093","volume":"8","author":[{"given":"Sunil J.","family":"Wimalawansa","sequence":"first","affiliation":[{"name":"Biochemical Endocrinology Unit, Departments Of Medicine (Endocrinology) And Chemical Pathology, Royal Postgraduate Medical School, London, England"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[1993,4,1]]},"reference":[{"key":"2024013113115632600_bib1","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1210\/jcem-19-1-152","article-title":"Medullary (solid) carcinoma of the thyroid. 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