{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T14:45:28Z","timestamp":1786977928571,"version":"build-2736575974"},"reference-count":39,"publisher":"Oxford University Press (OUP)","issue":"5","license":[{"start":{"date-parts":[[1994,5,1]],"date-time":"1994-05-01T00:00:00Z","timestamp":767750400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"name":"The CAFIR Foundation"},{"name":"The Medical Research Council of Canada","award":["MA-10226"],"award-info":[{"award-number":["MA-10226"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[1994,5,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>This study analyzes the parathyroid function in four dogs before and after 2 years of a low-calcium, high-sodium, vitamin D-deficient diet and the involution of the same function following (1) correction of dietary calcium deficiency and administration of IV 1,25-(OH)2D (0.25 \u03bcg twice per day) during 1 month, (2) after an additional month of normal dog chow supplemented with oral vitamin D (25 \u03bcg per day), and, finally, (3) after 5 and 17 months of a diet with normal levels of calcium and vitamin D. The parathyroid function was evaluated through IV infusion of CaCl2 and Na2 EDTA with measurement of intact (I) and carboxyl-terminal (C) immunoreactive parathyroid hormone (iPTH). The C-iPTH\/I-iPTH ratio was calculated to assess the modulation of molecular forms of iPTH induced by the various treatments. The 2 years of calcium and vitamin D deprivation lowered ionized calcium (1.23 \u00b1 0.04, p &amp;lt; 0.05) and 25-OHD (4.02 \u00b1 2.06 nM, p &amp;lt; 0.005) and tended to decrease 1,25-(OH)2D (80.8 \u00b1 8.6 pM); it increased basal I- and C-iPTH levels approximately eightfold (I-iPTH, 40.2 \u00b1 20.7, p &amp;lt; 0.05; C-iPTH, 185.4 \u00b1 94.9, p &amp;lt; 0.05) and stimulated I-iPTH (60.2 \u00b1 23.0 pM, p &amp;lt; 0.05) and C-iPTH (239.6 \u00b1 80.7 pM, p &amp;lt; 0.05) fivefold. A greater rise in nonsuppressible I-iPTH levels than in C-iPTH levels led to a decreased C-iPTH\/I-iPTH ratio in hypercalcemia (12.5 \u00b1 2.8 versus 27.8 \u00b1 6.05 pM, p &amp;lt; 0.005). Dietary deprivation also decreased the I-iPTH calcium stimulation set point (1.25 \u00b1 0.05 pM, p &amp;lt; 0.05). Treatment with dietary calcium and IV 1,25-(OH)2D normalized ionized calcium (1.34 \u00b1 0.02 mM) and basal I-iPTH level (6.09 \u00b1 5.48 pM) more than basal C-iPTH (69.8 \u00b1 48.8 pM), causing the C-iPTH\/I-iPTH ratio to increase from 4.80 \u00b1 0.81 to 14.8 \u00b1 6.1 (p &amp;lt; 0.05). Stimulated I-iPTH decreased (46.1 \u00b1 15.3 pM, p &amp;lt; 0.05), but stimulated C-iPTH secretion did not change (282.4 \u00b1 90.9 pM). A greater fall in the nonsuppressible I-iPTH level as opposed to C-iPTH level led the C-iPTH\/I-iPTH ratio to increase back to a normal value (23.8 \u00b1 1.40). The I-iPTH calcium stimulation set point remained low at 1.28 mM. Further consecutive treatment modalities over 18 months did not cause additional significant change in basal, stimulated, or nonsuppressible C-iPTH levels, but the same I-iPTH levels tended to decrease further. This explained why all three C-iPTH\/I-iPTH ratios tended either to increase (basal) or to increase significantly (stimulated and nonsuppressible, p &amp;lt; 0.05). The I-iPTH calcium stimulation set point again remained low. This study reveals that animals with hyperplastic parathyroid glands can control their I-iPTH level by maintaining a lower set point of I-iPTH stimulation by calcium and by changing their secretion profile with respect to carboxyl-terminal fragments of the PTH molecule.<\/jats:p>","DOI":"10.1002\/jbmr.5650090506","type":"journal-article","created":{"date-parts":[[2010,2,3]],"date-time":"2010-02-03T11:32:10Z","timestamp":1265196730000},"page":"621-629","source":"Crossref","is-referenced-by-count":23,"title":["Lack of involution of hyperplastic parathyroid glands in dogs: Adaptation via a decrease in the calcium stimulation set point and a change in secretion profile"],"prefix":"10.1093","volume":"9","author":[{"given":"M.","family":"Cloutier","sequence":"first","affiliation":[{"name":"Centre de recherche clinique Andr\u00e9-Viallet, H\u00f4pital Saint-Luc, and Department of Medicine, Universit\u00e9 de Montr\u00e9al, Montreal, Quebec, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.H.","family":"Brossard","sequence":"additional","affiliation":[{"name":"Centre de recherche clinique Andr\u00e9-Viallet, H\u00f4pital Saint-Luc, and Department of Medicine, Universit\u00e9 de Montr\u00e9al, Montreal, Quebec, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Gascon-Barr\u00e9","sequence":"additional","affiliation":[{"name":"Centre de recherche clinique Andr\u00e9-Viallet, H\u00f4pital Saint-Luc, and Department of Medicine, Universit\u00e9 de Montr\u00e9al, Montreal, Quebec, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pierre","family":"D'Amour","sequence":"additional","affiliation":[{"name":"Centre de recherche clinique Andr\u00e9-Viallet, H\u00f4pital Saint-Luc, and Department of Medicine, Universit\u00e9 de Montr\u00e9al, Montreal, Quebec, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[1994,5,1]]},"reference":[{"key":"2024013113125938400_bib1","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1001\/archinte.1969.00300200043008","article-title":"Secondary hyperparathyroidism in chronic renal failure. The clinical spectrum in uremia, during hemodialysis, and after renal transplantation","volume":"124","author":"Massry","year":"1969","journal-title":"Arch Intern Med"},{"key":"2024013113125938400_bib2","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1159\/000180743","article-title":"Secondary hyperparathyroidism in human kidney transplant recipients","volume":"17","author":"Pletka","year":"1976","journal-title":"Nephron"},{"key":"2024013113125938400_bib3","first-page":"440","article-title":"The high incidence of persistent secondary hyperparathyroidism after renal homotransplantation","volume":"143","author":"Chatterjee","year":"1976","journal-title":"Surg Gynecol Obstet"},{"key":"2024013113125938400_bib4","first-page":"472","article-title":"Parathyroid function after renal transplantation: Interrelationships between renal function, serum calcium and serum parathyroid hormone in normocalcemic long-term survivors","volume":"8","author":"Christensen","year":"1977","journal-title":"Clin Nephrol"},{"key":"2024013113125938400_bib5","first-page":"144","article-title":"Secondary hyperparathyroidism and its sequelae in renal transplant recipients","volume":"42","author":"Pieper","year":"1977","journal-title":"Scand J Urol Nephrol (Suppl)"},{"key":"2024013113125938400_bib6","first-page":"3721","article-title":"Calcium, hyperparathyroidism, and vitamin D metabolism after kidney transplantation","volume":"19","author":"De Francisco","year":"1987","journal-title":"Transplant Proc"},{"key":"2024013113125938400_bib7","first-page":"92","article-title":"Hypercalcemic hyperparathyroidism following renal transplantation: Differential diagnosis, management, and implications for cell population control in the parathyroid gland","volume":"8","author":"Parfitt","year":"1982","journal-title":"Miner Electrolyte Metab"},{"key":"2024013113125938400_bib8","doi-asserted-by":"crossref","first-page":"1536","DOI":"10.1093\/ajcn\/33.7.1536","article-title":"Posttransplantation hyperparathyroidism: Demonstration of retained control of parathyroid function by plasma ionized calcium","volume":"33","author":"McCarron","year":"1980","journal-title":"Am J Clin Nutr"},{"key":"2024013113125938400_bib9","doi-asserted-by":"crossref","first-page":"398","DOI":"10.1056\/NEJM197308232890804","article-title":"Hypercalcemia after renal transplantation. Long-term follow-up data","volume":"289","author":"David","year":"1973","journal-title":"N Engl J Med"},{"key":"2024013113125938400_bib10","first-page":"134","article-title":"Parathyroidectomy after renal transplantation","volume":"42","author":"Blohm\u00e9","year":"1977","journal-title":"Scand J Urol Nephrol (Suppl)"},{"key":"2024013113125938400_bib11","doi-asserted-by":"crossref","first-page":"578","DOI":"10.1001\/archsurg.1985.01390290056009","article-title":"Management of hypercalcemic hyperparathyroidism after renal transplantation","volume":"120","author":"Garvin","year":"1985","journal-title":"Arch Surg"},{"key":"2024013113125938400_bib12","first-page":"1049","article-title":"Tertiary hyperparathyroidism after renal transplantation: Operative indications","volume":"106","author":"D'Alessandro","year":"1989","journal-title":"Surgery"},{"key":"2024013113125938400_bib13","doi-asserted-by":"crossref","first-page":"535","DOI":"10.1210\/jcem-59-3-535","article-title":"Persistence of parathyroid hypersecretion after vitamin D treatment in Asian vegetarians","volume":"59","author":"Dandona","year":"1984","journal-title":"J Clin Endocrinol Metab"},{"key":"2024013113125938400_bib14","doi-asserted-by":"crossref","first-page":"678","DOI":"10.1172\/JCI108324","article-title":"Parathyroid hormone in vivo. 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A role for increased sensitivity to calcium","volume":"83","author":"Delmez","year":"1989","journal-title":"J Clin Invest"},{"key":"2024013113125938400_bib31","doi-asserted-by":"crossref","first-page":"1093","DOI":"10.1038\/ki.1989.305","article-title":"Direct inhibitory effect of calcitriol on parathyroid function (sigmoidal curve) in dialysis","volume":"36","author":"Dunlay","year":"1989","journal-title":"Kidney Int"},{"key":"2024013113125938400_bib32","doi-asserted-by":"crossref","first-page":"4270","DOI":"10.1073\/pnas.82.12.4270","article-title":"Regulation by vitamin D metabolites of messenger ribonucleic acid for preproparathyroid hormone in isolated bovine parathyroid cells","volume":"82","author":"Silver","year":"1985","journal-title":"Proc Natl Acad Sci USA"},{"key":"2024013113125938400_bib33","doi-asserted-by":"crossref","first-page":"1296","DOI":"10.1172\/JCI112714","article-title":"Regulation by vitamin D metabolites of parathyroid gene transcription in vivo in the rat","volume":"78","author":"Silver","year":"1986","journal-title":"J Clin Invest"},{"key":"2024013113125938400_bib34","doi-asserted-by":"crossref","first-page":"2864","DOI":"10.1210\/endo-119-6-2864","article-title":"Suppression by 1,25(OH)2D3 of transcription of the pre-proparathyroid hormone gene","volume":"119","author":"Russell","year":"1986","journal-title":"Endocrinology"},{"key":"2024013113125938400_bib35","doi-asserted-by":"crossref","first-page":"1049","DOI":"10.1038\/ki.1989.89","article-title":"1,25(OH)2 vitamin D3 inhibits parathyroid cell proliferation in experimental uremia","volume":"35","author":"Szabo","year":"1989","journal-title":"Kidney Int"},{"key":"2024013113125938400_bib36","doi-asserted-by":"crossref","first-page":"1097","DOI":"10.1172\/JCI112666","article-title":"Hypocalcemia may not be essential for the development of secondary hyperparathyroidism in chronic renal failure","volume":"78","author":"Lopez-Hilker","year":"1986","journal-title":"J Clin Invest"},{"key":"2024013113125938400_bib37","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1016\/0169-6009(90)90036-F","article-title":"Low calcium diet in dogs causes a greater increase in parathyroid function measured with an intact hormone than with a carboxylterminal assay","volume":"9","author":"Cloutier","year":"1990","journal-title":"Bone Miner"},{"key":"2024013113125938400_bib38","doi-asserted-by":"crossref","first-page":"915","DOI":"10.1210\/endo-93-4-915","article-title":"Studies on the biosynthesis of rat parathyroid hormone and proparathyroid hormone: Adaptation of the parathyroid gland to dietary restriction of calcium","volume":"93","author":"Chu","year":"1973","journal-title":"Endocrinology"},{"key":"2024013113125938400_bib39","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1210\/jcem-54-1-172","article-title":"Abnormal regulation of parathyroid hormone release by calcium in secondary hyperparathyroidism due to chronic renal failure","volume":"54","author":"Brown","year":"1982","journal-title":"J Clin Endocrinol Metab"}],"container-title":["Journal of Bone and Mineral Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fjbmr.5650090506","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/academic.oup.com\/jbmr\/article-pdf\/9\/5\/621\/56497542\/5650090506.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/jbmr\/article-pdf\/9\/5\/621\/56497542\/5650090506.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,3,13]],"date-time":"2024-03-13T10:58:12Z","timestamp":1710327492000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/jbmr\/article\/9\/5\/621-629\/7501043"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1994,5,1]]},"references-count":39,"journal-issue":{"issue":"5","published-online":{"date-parts":[[1994,5,1]]},"published-print":{"date-parts":[[1994,5,1]]}},"URL":"https:\/\/doi.org\/10.1002\/jbmr.5650090506","relation":{},"ISSN":["0884-0431","1523-4681"],"issn-type":[{"value":"0884-0431","type":"print"},{"value":"1523-4681","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[1994,5,1]]},"published":{"date-parts":[[1994,5,1]]}}}