{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,21]],"date-time":"2025-10-21T03:20:46Z","timestamp":1761016846486},"reference-count":23,"publisher":"Oxford University Press (OUP)","issue":"5","license":[{"start":{"date-parts":[[1994,5,1]],"date-time":"1994-05-01T00:00:00Z","timestamp":767750400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"name":"The Swedish Medical Research Council","award":["B93-17X-09906-02B"],"award-info":[{"award-number":["B93-17X-09906-02B"]}]},{"name":"The Anders Jahres Foundation"},{"name":"The Aase Bye and Trygve J.B. 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During muscle contraction in vivo, the ultimate bending moment, energy absorption, bending stiffness, and deflection were significantly lower in the osteopenic than in the sham-operated animals. However, the increase in mechanical parameters due to muscle contraction comparing the in vivo and resected tibiae in each animal were equally high in the osteopenic and sham-operated animals. Ultimate bending moment in the resected tibiae was 10% higher in the sham-operated animals compared with the ovariectomized, proving mechanically weaker tibiae in the osteopenic rats. In accordance with this, the medullary area of the osteopenic rats was 46% larger in the distal tibial diaphysis, and the ultimate stress the tibiae could withstand was 15% lower in the osteopenic compared with the sham-operated rats. The trabecular bone volume in the distal tibial metaphysis of the osteopenic rats was reduced by 70% compared with the sham operated. This study shows that muscle protection against fracture can be substantial in osteopenic tibia and that it is of the same magnitude as in rats with normal bone mass.<\/jats:p>","DOI":"10.1002\/jbmr.5650090513","type":"journal-article","created":{"date-parts":[[2010,2,3]],"date-time":"2010-02-03T16:32:10Z","timestamp":1265214730000},"page":"679-685","source":"Crossref","is-referenced-by-count":11,"title":["Muscle contraction increases the in vivo structural strength to the same degree in osteopenic and normal rat tibiae"],"prefix":"10.1093","volume":"9","author":[{"given":"Lars","family":"Nordsletten","sequence":"first","affiliation":[{"name":"Institute for Surgical Research, Rikshospitalet (National Hospital), Oslo, Norway"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Trine S.","family":"Kaastad","sequence":"additional","affiliation":[{"name":"Sophies Minde Ortopaedic Hospital, Oslo, Norway"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Karl J.","family":"Obrant","sequence":"additional","affiliation":[{"name":"Department of Orthopaedics, Malm\u00f8; General Hospital, University of Lund, Malm\u00f8;, Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sigmund","family":"Skjeldal","sequence":"additional","affiliation":[{"name":"Sophies Minde Ortopaedic Hospital, Oslo, Norway"},{"name":"Institute for Surgical Research, Rikshospitalet (National Hospital), Oslo, Norway"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ole J.","family":"Kirkeby","sequence":"additional","affiliation":[{"name":"Institute for Surgical Research, Rikshospitalet (National Hospital), Oslo, Norway"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Oddvar","family":"Stokke","sequence":"additional","affiliation":[{"name":"Department of Clinical Chemistry, Rikshospitalet (National Hospital), Oslo, Norway"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Arne","family":"Ekeland","sequence":"additional","affiliation":[{"name":"Surgical Clinic, Ullev\u00e5l Hospital, Oslo, Norway"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[1994,5,1]]},"reference":[{"key":"2024013113125996500_bib1","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1016\/8756-3282(92)90359-5","article-title":"Differences in cortical bone in overloaded and underloaded femurs from ovariectomized rats\u2014comparison of bone morphometry with torsional testing","volume":"13","author":"Bagi","year":"1992","journal-title":"Bone"},{"key":"2024013113125996500_bib2","doi-asserted-by":"crossref","first-page":"67","DOI":"10.3109\/17453678608993219","article-title":"Bone changes after castration in rats. 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