{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T12:51:58Z","timestamp":1788871918436,"version":"build-2803163510"},"reference-count":16,"publisher":"Oxford University Press (OUP)","issue":"7","license":[{"start":{"date-parts":[[1994,7,1]],"date-time":"1994-07-01T00:00:00Z","timestamp":773020800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"DOI":"10.13039\/501100004937","name":"Bundesministerium f\u00fcr Forschung und Technologie","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100004937","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[1994,7,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Urinary excretion of type I collagen cross-linked N-telopeptides was studied in 52 children and adolescents with osteogenesis imperfecta (OI) and found to be above the 75th percentile of controls in 44 of the patients. OI patients suffering from fractures during the preceding 6 months had significantly higher values (p &amp;lt; 0.05). In contrast, patients with better motor performance tended to have lower values (p = 0.059). The concentration of urinary type I collagen cross-linked N-telopeptides was positively correlated with urinary calcium excretion (p &amp;lt; 0.05), which was found to be elevated in 20 of the patients. Our results show that during childhood and adolescence in OI not only the synthesis but also the turnover of mature cross-linked type I collagen is disturbed and provide evidence that bone resorption rates are elevated.<\/jats:p>","DOI":"10.1002\/jbmr.5650090706","type":"journal-article","created":{"date-parts":[[2010,2,3]],"date-time":"2010-02-03T11:33:05Z","timestamp":1265196785000},"page":"993-997","source":"Crossref","is-referenced-by-count":55,"title":["Bone resorption assessed by immunoassay of urinary cross-linked collagen peptides in patients with osteogenesis imperfecta"],"prefix":"10.1093","volume":"9","author":[{"given":"Rolf E.","family":"Dr. Brenner","sequence":"first","affiliation":[{"name":"Department of Pediatrics I, University of Ulm, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ulrich","family":"Vetter","sequence":"additional","affiliation":[{"name":"Department of Pediatrics I, University of Frankfurt, Frankfurt, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anne-Marie","family":"Bollen","sequence":"additional","affiliation":[{"name":"Department of Orthodontics, University of Washington, Seattle, Washington"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin","family":"M\u00f6rike","sequence":"additional","affiliation":[{"name":"Department of Pediatrics I, University of Ulm, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David R.","family":"Eyre","sequence":"additional","affiliation":[{"name":"Department of Orthopaedics, University of Washington, Seattle, Washington"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[1994,7,1]]},"reference":[{"key":"2024013113125089900_bib1","volume-title":"McKusick's Heritable Disorders of Connective Tissue","author":"Beighton","year":"1992","edition":"5th ed."},{"key":"2024013113125089900_bib2","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1136\/jmg.28.7.433","article-title":"Osteogenesis imperfecta: Translation of mutation to phenotype","volume":"28","author":"Byers","year":"1991","journal-title":"J Med Genet"},{"key":"2024013113125089900_bib3","first-page":"508","article-title":"Osteogenesis imperfecta type I is commonly due to a COL1A1 null allele of type I collagen","volume":"51","author":"Willing","year":"1992","journal-title":"Am J Hum Genet"},{"key":"2024013113125089900_bib4","doi-asserted-by":"crossref","first-page":"2052","DOI":"10.1096\/fasebj.5.7.2010058","article-title":"Mutations in collagen genes: Causes of rare and some common diseases in humans","volume":"5","author":"Kuivaniemi","year":"1991","journal-title":"FASEB J"},{"key":"2024013113125089900_bib5","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1002\/jbmr.5650080203","article-title":"Collagen crosslinks and mineral cristallinity in bone of patients with osteogenesis imperfecta","volume":"8","author":"Vetter","year":"1993","journal-title":"J Bone Miner Res"},{"key":"2024013113125089900_bib6","doi-asserted-by":"crossref","first-page":"204","DOI":"10.1203\/00006450-198303000-00007","article-title":"Increased bone turnover with decreased bone formation by osteoblasts in children with osteogenesis imperfecta tarda","volume":"17","author":"Baron","year":"1983","journal-title":"Pediatr Res"},{"key":"2024013113125089900_bib7","doi-asserted-by":"crossref","first-page":"346","DOI":"10.1210\/jcem-44-2-346","article-title":"Effect of long-term calcitonin therapy on the clinical course of osteogenesis imperfecta","volume":"44","author":"Rosenberg","year":"1977","journal-title":"J Clin Endocrinol Metab"},{"key":"2024013113125089900_bib8","doi-asserted-by":"crossref","first-page":"1251","DOI":"10.1002\/jbmr.5650071119","article-title":"A specific immunoassay for monitoring human bone resorption: Quantitation of type I collagen cross-linked N-telopeptides in urine","volume":"7","author":"Hanson","year":"1992","journal-title":"J Bone Miner Res"},{"key":"2024013113125089900_bib9","doi-asserted-by":"crossref","first-page":"470A","DOI":"10.1210\/jcem.74.3.1740477","article-title":"New biomarkers of bone resorption (editorial)","volume":"74","author":"Eyre","year":"1992","journal-title":"J Clin Endocrinol Metab"},{"key":"2024013113125089900_bib10","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1136\/jmg.16.2.101","article-title":"Genetic heterogeneity in osteogenesis imperfecta","volume":"16","author":"Sillence","year":"1979","journal-title":"J Med Genet"},{"key":"2024013113125089900_bib11","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1136\/adc.49.2.97","article-title":"Urinary excretion of calcium and magnesium in children","volume":"49","author":"Ghazali","year":"1974","journal-title":"Arch Dis Child"},{"key":"2024013113125089900_bib12","author":"Bollen"},{"key":"2024013113125089900_bib13","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1007\/BF02009659","article-title":"Radiological \u201cmetamorphosis\u201d in a patient with severe congenital osteogenesis imperfecta","volume":"149","author":"Pendola","year":"1990","journal-title":"Eur J Pediatr"},{"key":"2024013113125089900_bib14","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1016\/S0022-3476(05)81038-8","article-title":"Hypercalciuria in children severely affected with osteogenesis imperfecta","volume":"119","author":"Chines","year":"1991","journal-title":"J Pediatr"},{"key":"2024013113125089900_bib15","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1007\/BF01958277","article-title":"Osteogenesis imperfecta in childhood: Cardiac and renal manifestations","volume":"149","author":"Vetter","year":"1989","journal-title":"Eur J Pediatr"},{"key":"2024013113125089900_bib16","doi-asserted-by":"crossref","first-page":"648","DOI":"10.1136\/ard.51.5.648","article-title":"Urinary excretion of pyridinium crosslinks of collagen in patients with osteoporosis and the effects of bone fracture","volume":"51","author":"McLaren","year":"1992","journal-title":"Ann Rheum Dis"}],"container-title":["Journal of Bone and Mineral Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fjbmr.5650090706","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/academic.oup.com\/jbmr\/article-pdf\/9\/7\/993\/56495040\/5650090706.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/jbmr\/article-pdf\/9\/7\/993\/56495040\/5650090706.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,3,13]],"date-time":"2024-03-13T10:58:33Z","timestamp":1710327513000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/jbmr\/article\/9\/7\/993-997\/7500823"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1994,7,1]]},"references-count":16,"journal-issue":{"issue":"7","published-online":{"date-parts":[[1994,7,1]]},"published-print":{"date-parts":[[1994,7,1]]}},"URL":"https:\/\/doi.org\/10.1002\/jbmr.5650090706","relation":{},"ISSN":["0884-0431","1523-4681"],"issn-type":[{"value":"0884-0431","type":"print"},{"value":"1523-4681","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[1994,7,1]]},"published":{"date-parts":[[1994,7,1]]}}}