{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T20:29:25Z","timestamp":1791404965829,"version":"4.3.3"},"reference-count":33,"publisher":"Oxford University Press (OUP)","issue":"9","license":[{"start":{"date-parts":[[1994,9,1]],"date-time":"1994-09-01T00:00:00Z","timestamp":778377600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"name":"Novo Nordisk AJS"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[1994,9,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>The cause of bone loss in patients with osteoporosis is not known, but both increased bone resorption and decreased bone formation have been reported. Theoretically, these effects may result from either increased activity of osteoclasts or decreased activity of osteoblasts, or both. In vivo, growth hormone (GH) administration leads to activation of osteoclasts and osteoblasts as evidenced by increased biochemical markers of bone resorption and bone formation. To test for disturbances in responsiveness of bone cells to exogenous hormonal stimuli in osteoporosis, we compared 15 patients with postmenopausal osteoporosis with 15 healthy age-matched postmenopausal women before and during a 3 day stimulation test with GH (0.2 IU\/kg\/day). Serum insulin-like growth factor I increased in both groups (p &amp;lt; 0.001). GH treatment increased biochemical markers of bone resorption (serum carboxyl-terminal telopeptide of type I collagen [ICTP] [p &amp;lt; 0.001] and, to a lesser extent, 24 h urinary hydroxyproline\/creatinine) in the two groups. Similarly, biochemical markers for bone formation increased in both groups [osteocalcin (p &amp;lt; 0.01) and procollagen type I C-terminal propeptide, PICP (p &amp;lt; 0.001)]. GH treatment reduced alkaline phosphatase (ALP, p &amp;lt; 0.05) and its bone-specific isoenzyme (bone ALP, p &amp;lt; 0.01) in both groups. The maximal response, the area under the curve (AUC) of response curves for IGF-I, bone resorption markers, and bone formation markers were not different between groups. Our data do not support the hypothesis that osteoporotic patients display major disturbances in responsiveness to GH.<\/jats:p>","DOI":"10.1002\/jbmr.5650090907","type":"journal-article","created":{"date-parts":[[2010,2,3]],"date-time":"2010-02-03T16:43:42Z","timestamp":1265215422000},"page":"1365-1370","source":"Crossref","is-referenced-by-count":35,"title":["Normal osteoclastic and osteoblastic responses to exogenous growth hormone in patients with postmenopausal spinal osteoporosis"],"prefix":"10.1093","volume":"9","author":[{"given":"M.","family":"Kassem","sequence":"first","affiliation":[{"name":"Aarhus Bone and Mineral Research Group, Department of Endocrinology and Metabolism, Aarhus University Hospital, Aarhus Amtssygehus, Aarhus, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K.","family":"DR. Brixen","sequence":"additional","affiliation":[{"name":"Aarhus Bone and Mineral Research Group, Department of Endocrinology and Metabolism, Aarhus University Hospital, Aarhus Amtssygehus, Aarhus, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"W.F.","family":"Blum","sequence":"additional","affiliation":[{"name":"2Universit\u00e4ts Kinderklinik, T\u00fcbingen, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L.","family":"Mosekilde","sequence":"additional","affiliation":[{"name":"Aarhus Bone and Mineral Research Group, Department of Endocrinology and Metabolism, Aarhus University Hospital, Aarhus Amtssygehus, Aarhus, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E.F.","family":"Eriksen","sequence":"additional","affiliation":[{"name":"Aarhus Bone and Mineral Research Group, Department of Endocrinology and Metabolism, Aarhus University Hospital, Aarhus Amtssygehus, Aarhus, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[1994,9,1]]},"reference":[{"key":"2024013113131758700_bib1","first-page":"45","volume-title":"Osteoporosis: Etiology, Diagnosis, and Management","author":"Parfitt","year":"1988"},{"key":"2024013113131758700_bib2","doi-asserted-by":"crossref","first-page":"1331","DOI":"10.1002\/jbmr.5650061210","article-title":"A new method for measuring cancellous bone erosion depth\u2013application to the cellular mechanisms of bone loss in postmenopausal osteoporosis","volume":"6","author":"Cohen-Solal","year":"1991","journal-title":"J Bone Miner Res"},{"key":"2024013113131758700_bib3","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1002\/jbmr.5650050402","article-title":"Cancellous bone remodeling in type I (postmenopausal) osteoporosis: Quantitative assessment of rates of formation, resorption, and bone loss at tissue and cellular levels","volume":"5","author":"Eriksen","year":"1990","journal-title":"J Bone Miner Res"},{"key":"2024013113131758700_bib4","doi-asserted-by":"crossref","first-page":"818","DOI":"10.1056\/NEJM198803313181305","article-title":"Local and systemic factors in the pathogenesis of osteoporosis","volume":"318","author":"Raisz","year":"1988","journal-title":"N Engl J Med"},{"key":"2024013113131758700_bib5","first-page":"429","author":"Parfitt","year":"1990"},{"key":"2024013113131758700_bib6","doi-asserted-by":"crossref","first-page":"2254","DOI":"10.1172\/JCI112234","article-title":"Estimation of bone turnover evaluated by 47Ca-kinetics. 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