{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T15:52:31Z","timestamp":1785426751674,"version":"3.56.0"},"reference-count":47,"publisher":"Oxford University Press (OUP)","issue":"11","license":[{"start":{"date-parts":[[1994,11,1]],"date-time":"1994-11-01T00:00:00Z","timestamp":783648000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"name":"NIH","award":["DE 07489"],"award-info":[{"award-number":["DE 07489"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[1994,11,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>A common, but paradoxic, feature among osteopetrotic human infants is the presence of rickets. This disorder of mineralization is manifested radiographically and histologically by increased growth plate cartilage and hypertrophic cell zone thickness and excess metaphyseal osteoid and biochemically by decreased serum calcium and phosphorus concentrations. Rickets has also been reported in two osteopetrotic animal mutations, the osteosclerotic (oc) mouse and the toothless (tl) rat. Although the phenotypic expression of the rachitic lesion in the oc mouse closely resembles that in affected humans, the results of the present study show that the lesion in the tl rat does not. Compared with normal littermates, histologic and morphometric analyses of tibial growth plate cartilage in tl rats up to 5 weeks of age showed age-related increases in thickness of the proliferative cell zone and decreases in thickness of the hypertrophic cell zone that were most apparent within the central, but not lateral, regions of the growth plate and areas of acellularity and failure of chondrocytes to transform synchronously from proliferative cell to hypertrophic cell phenotypes. Femoral ash content, composition, and accretion rates did not differ from those in normal rats during the first 5 weeks of life. These findings do not support the rachitic nature of the cartilage lesion in the tl rat. Rather, a chondrodysplastic disorder is suggested, which more closely resembles the cartilage defect present in this mutation.<\/jats:p>","DOI":"10.1002\/jbmr.5650091119","type":"journal-article","created":{"date-parts":[[2010,2,3]],"date-time":"2010-02-03T16:26:55Z","timestamp":1265214415000},"page":"1813-1821","source":"Crossref","is-referenced-by-count":19,"title":["Lack of evidence for rickets in the osteopetrotic rat mutation, toothless"],"prefix":"10.1093","volume":"9","author":[{"given":"Mark F.","family":"Seifert","sequence":"first","affiliation":[{"name":"Department of Anatomy, Indiana University School of Medicine, Indianapolis, Indiana"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[1994,11,1]]},"reference":[{"key":"2024020719364177000_bib1","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1097\/00003086-198410000-00026","article-title":"Congenital osteopetrotic mutations as probes of the origin, structure and function of osteoclasts","volume":"189","author":"Marks","year":"1984","journal-title":"Clin Orthop"},{"key":"2024020719364177000_bib2","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1016\/0221-8747(81)90032-1","article-title":"The pathogenesis of infantile malignant osteopetrosis: Bone mineral metabolism and complications in five infants","volume":"3","author":"Reeves","year":"1981","journal-title":"Metab Bone Dis"},{"key":"2024020719364177000_bib3","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1002\/jbmr.5650070103","article-title":"Mineral metabolism in infants with malignant osteopetrosis: Heterogeneity in plasma 1,25-dihydroxyvitamin D levels and bone histology","volume":"7","author":"Cournot","year":"1992","journal-title":"J Bone Miner Res"},{"key":"2024020719364177000_bib4","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1016\/S0022-3476(05)82557-0","article-title":"Recombinant human interferon gamma therapy for osteopetrosis","volume":"121","author":"Key","year":"1992","journal-title":"J Pediatr"},{"key":"2024020719364177000_bib5","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1056\/NEJM198402163100701","article-title":"Treatment of congenital osteopetrosis with high-dose calcitriol","volume":"310","author":"Key","year":"1984","journal-title":"N Engl J Med"},{"key":"2024020719364177000_bib6","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1007\/BF02555149","article-title":"Variable osteoclast appearance in human infantile osteopetrosis","volume":"43","author":"Shapiro","year":"1988","journal-title":"Calcif Tissue Int"},{"key":"2024020719364177000_bib7","doi-asserted-by":"crossref","first-page":"580","DOI":"10.1016\/S0022-3476(80)80012-6","article-title":"Osteopetrosis: Further heterogeneity","volume":"97","author":"Horton","year":"1980","journal-title":"J Pediatr"},{"key":"2024020719364177000_bib8","doi-asserted-by":"crossref","first-page":"701","DOI":"10.1056\/NEJM198003273021301","article-title":"Successful bone-marrow transplantation for infantile malignant osteopetrosis","volume":"302","author":"Coccia","year":"1980","journal-title":"N Engl J Med"},{"key":"2024020719364177000_bib9","doi-asserted-by":"crossref","first-page":"617","DOI":"10.2106\/00004623-198870040-00021","article-title":"Successful treatment of infantile malignant osteopetrosis by bone-marrow transplantation","volume":"70","author":"Kaplan","year":"1988","journal-title":"J Bone Joint Surg [Am]"},{"key":"2024020719364177000_bib10","doi-asserted-by":"crossref","first-page":"1280","DOI":"10.1016\/0002-9343(81)90839-1","article-title":"Marrow transplantation for juvenile osteopetrosis","volume":"70","author":"Sorell","year":"1981","journal-title":"Am J Med"},{"key":"2024020719364177000_bib11","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1002\/ajmg.1320340110","article-title":"Osteoclast biology: Lessons from mammalian mutations","volume":"34","author":"Marks","year":"1989","journal-title":"Am J Med Genet"},{"key":"2024020719364177000_bib12","first-page":"172","article-title":"Osteopetrosis-multiple pathways for the interception of osteoclast function","volume":"5","author":"Marks","year":"1987","journal-title":"Appl Pathol"},{"key":"2024020719364177000_bib13","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1097\/00003086-199309000-00004","article-title":"Experimental studies of osteopetrosis in laboratory animals","volume":"294","author":"Seifert","year":"1993","journal-title":"Clin Orthop"},{"key":"2024020719364177000_bib14","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1007\/BF00432412","article-title":"Osteopetrosis fetalis. 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