{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,21]],"date-time":"2025-10-21T03:20:47Z","timestamp":1761016847889},"reference-count":17,"publisher":"Oxford University Press (OUP)","issue":"11","license":[{"start":{"date-parts":[[1994,11,1]],"date-time":"1994-11-01T00:00:00Z","timestamp":783648000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[1994,11,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Several bisphosphonates are under investigation for the treatment and prevention of postmenopausal osteoporosis. Alendronate, one of these compounds, has been shown to inhibit bone turnover and induce substantial increases in bone mass, but little is known about the duration of its effects. This is considered important, keeping in mind the long half-life of bisphosphonate in bone. In this double-blind controlled study, two groups of 15 postmenopausal women with spinal bone mineral density (BMD) &amp;gt; 2 SD below adult mean peak without vertebral fractures were randomized to receive either alendronate, 20 mg\/day, or placebo for 6 months. The treatment course with alendronate significantly suppressed all indices of bone turnover (hydrox-yproline, collagen crosslinks, and alkaline phosphatase activity) within 3 months, and a further slight decrease was observed in the subsequent 3 months. After treatment withdrawal, all indices of bone turnover slowly increased, and they attained the pretreatment values within 6\u20139 months. Lumbar spine BMD rose by 3.7% (\u00b1 1.7 SD) after 6 months of alendronate therapy but did not change 6 and 12 months after treatment withdrawal (4.6 \u00b1 2.8 and 4.7 \u00b1 2.6% versus baseline, respectively). In control patients a slow decrease in lumbar spine BMD was observed, but this was significant only at month 18 of the study. Femoral BMD did not significantly change in the alendronate group, but it slowly decreased in the control group at all sites of evaluation. The fractional loss became statistically significant versus both baseline and the active group by the end of the study only at the level of the femoral neck. These results may imply that the positive bone balance induced by alendronate is sustained long after stopping therapy, despite the reestablishment of pretreatment bone turnover.<\/jats:p>","DOI":"10.1002\/jbmr.5650091121","type":"journal-article","created":{"date-parts":[[2010,2,3]],"date-time":"2010-02-03T16:26:55Z","timestamp":1265214415000},"page":"1833-1837","source":"Crossref","is-referenced-by-count":76,"title":["Long-term effects of a treatment course with oral alendronate of postmenopausal osteoporosis"],"prefix":"10.1093","volume":"9","author":[{"given":"M.","family":"Rossini","sequence":"first","affiliation":[{"name":"Istituto di Semeiotica e Nefrolgia Medica, University of Verona, Verona, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D.","family":"Gatti","sequence":"additional","affiliation":[{"name":"Istituto di Semeiotica e Nefrolgia Medica, University of Verona, Verona, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"N.","family":"Zamberlan","sequence":"additional","affiliation":[{"name":"Istituto di Semeiotica e Nefrolgia Medica, University of Verona, Verona, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"V.","family":"Braga","sequence":"additional","affiliation":[{"name":"Istituto di Semeiotica e Nefrolgia Medica, University of Verona, Verona, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R.","family":"Dorizzi","sequence":"additional","affiliation":[{"name":"Ospedale di Legnago, Verona, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.","family":"Adami","sequence":"additional","affiliation":[{"name":"Istituto di Semeiotica e Nefrolgia Medica, University of Verona, Verona, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[1994,11,1]]},"reference":[{"issue":"6","key":"2024020719362676100_bib1","doi-asserted-by":"crossref","first-page":"919","DOI":"10.2165\/00003495-199142060-00003","article-title":"Bisphosphonates","volume":"42","author":"Fleisch","year":"1991","journal-title":"Drugs"},{"key":"2024020719362676100_bib2","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1097\/00003086-198704000-00011","article-title":"Long-term follow-up observations on treatment in Paget's disease of bone","volume":"217","author":"Kanis","year":"1987","journal-title":"Clin Orthop"},{"key":"2024020719362676100_bib3","doi-asserted-by":"crossref","first-page":"1469","DOI":"10.1016\/S0140-6736(89)92927-9","article-title":"Prevention of postmenopausal bone loss by tiludronate","volume":"2","author":"Reginster","year":"1989","journal-title":"Lancet"},{"issue":"suppl","key":"2024020719362676100_bib4","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1016\/S8756-3282(09)80009-4","article-title":"The use of bisphosphonates in the treatment of osteoporosis","volume":"13","author":"Papapoulos","year":"1992","journal-title":"Bone"},{"key":"2024020719362676100_bib5","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1056\/NEJM199007123230201","article-title":"Intermittent cyclical etidronate treatment of postmenopausal osteoporosis","volume":"323","author":"Watts","year":"1990","journal-title":"N Engl J Med"},{"key":"2024020719362676100_bib6","doi-asserted-by":"crossref","first-page":"1265","DOI":"10.1056\/NEJM199005033221803","article-title":"Effect of intermittent cyclical etidronate therapy on bone mass and fracture rate in women with postmenopausal osteoporosis","volume":"322","author":"Storm","year":"1990","journal-title":"N Engl J Med"},{"issue":"Suppl. 3","key":"2024020719362676100_bib7","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1007\/BF01623004","article-title":"Treatment of postmenopausal osteoporisis with continuous daily oral alendronate in comparison with either placebo or intranasal salmon calcitonin","volume":"3","author":"Adami","year":"1993","journal-title":"Osteoporosis Int"},{"key":"2024020719362676100_bib8","doi-asserted-by":"crossref","first-page":"951","DOI":"10.1002\/jbmr.5650070812","article-title":"The bisphosphonate, alendronate, prevents bone loss in ovariectomized baboons","volume":"7","author":"Toolan","year":"1992","journal-title":"J Bone Miner Res"},{"key":"2024020719362676100_bib9","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1002\/jbmr.5650060405","article-title":"The bisphosphonate alendronate (MK-217) inhibits bone loss due to ovariectomy in rats","volume":"6","author":"Seedor","year":"1991","journal-title":"J Bone Miner Res"},{"issue":"Suppl. 1","key":"2024020719362676100_bib10","first-page":"S131","article-title":"Oral alendronate treatment of bone loss in postmenopausal osteopenic women","volume":"8","author":"Santora","year":"1993","journal-title":"J Bone Miner Res"},{"issue":"Suppl. 1","key":"2024020719362676100_bib11","first-page":"S141","article-title":"Alendronate prevents or reverses bone loss at the spine and hip in recently menopausal women","volume":"8","author":"McClung","year":"1993","journal-title":"J Bone Miner Res"},{"key":"2024020719362676100_bib12","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1007\/BF02406145","article-title":"Age-related structural changes in trabecular and cortical bone: Cellular mechanisms and biomechanical consequences","volume":"36","author":"Parfitt","year":"1984","journal-title":"Calcif Tissue Int"},{"key":"2024020719362676100_bib13","first-page":"1399","article-title":"The effect of short-term treatment with alendronate upon vertebral density and biochemical markers of bone remodeling in early postmenopausal women","volume":"76","author":"Harris","year":"1993","journal-title":"J Clin Endocrinol Metab"},{"key":"2024020719362676100_bib14","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1016\/S0169-6009(08)80249-8","article-title":"Duration of the effects of intravenous alendronate in postmenopausal women and in patients with primary hyperparathyroidism","volume":"25","author":"Adami","year":"1994","journal-title":"Bone Miner"},{"key":"2024020719362676100_bib15","doi-asserted-by":"crossref","first-page":"2095","DOI":"10.1172\/JCI115539","article-title":"Bisphosphonate action","volume":"88","author":"Sato","year":"1991","journal-title":"J Clin Invest"},{"key":"2024020719362676100_bib16","doi-asserted-by":"crossref","first-page":"2577","DOI":"10.1172\/JCI116872","article-title":"Effects of two year treatment with the aminobisphosphonate alendronate on bone metabolism, bone histomorphometry and bone strength on ovariectomized non-human primates","volume":"92","author":"Balena","year":"1993","journal-title":"J Clin Invest"},{"issue":"Suppl. 1","key":"2024020719362676100_bib17","first-page":"S24","article-title":"Wall thickness and resorption depth in cancellous bone of ovariectomized (OVX) baboons treated with alendronate","volume":"25","author":"Balena","year":"1994","journal-title":"Bone Miner"}],"container-title":["Journal of Bone and Mineral Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fjbmr.5650091121","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/academic.oup.com\/jbmr\/article-pdf\/9\/11\/1833\/56493640\/5650091121.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/jbmr\/article-pdf\/9\/11\/1833\/56493640\/5650091121.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,3,13]],"date-time":"2024-03-13T14:59:30Z","timestamp":1710341970000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/jbmr\/article\/9\/11\/1833-1837\/7500621"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1994,11,1]]},"references-count":17,"journal-issue":{"issue":"11","published-online":{"date-parts":[[1994,11,1]]},"published-print":{"date-parts":[[1994,11,1]]}},"URL":"https:\/\/doi.org\/10.1002\/jbmr.5650091121","relation":{},"ISSN":["0884-0431","1523-4681"],"issn-type":[{"value":"0884-0431","type":"print"},{"value":"1523-4681","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[1994,11,1]]},"published":{"date-parts":[[1994,11,1]]}}}