{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,3,14]],"date-time":"2024-03-14T00:38:24Z","timestamp":1710376704812},"reference-count":24,"publisher":"Oxford University Press (OUP)","issue":"12","license":[{"start":{"date-parts":[[1994,12,1]],"date-time":"1994-12-01T00:00:00Z","timestamp":786240000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[1994,12,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>The evidence for a role of parathyroid hormone in the bone loss after the menopause remains controversial. This study examines the effect of parathyroidectomy on femoral trabecular bone volume, thickness, and spacing and biochemical markers of bone turnover in the oophorectomized rat. Female Sprague-Dawley rats 3 months old were double sham operated (sham), oophorectomized (OPX), parathyroidectomized (PTX), or oophorectomized and parathyroidectomized (O\/P) under halothane anesthesia. At 9 weeks postoperation, femoral trabecular bone volume (BV\/TV) was lower in OPX and O\/P rats compared with sham or PTX animals (BV\/TV, %, mean + SEM): sham 25.9 + 0.5, OPX 15.1 + 0.9, PTX 24.1 + 0.9, O\/P 17.3 + 0.5; p &amp;lt; 0.001). Urinary hydroxyproline excretion, serum osteocalcin, and alkaline phosphatase activity were higher in OPX and O\/P rats compared with control animals at 3 weeks postoperation (OHPE \u03bcM GF, mean + SEM: sham 1.37 + 0.16, OPX 2.16 + 0.26, PTX 0.95 + 0.21, O\/P 1.92 + 0.22, p &amp;lt; 0.005; osteocalcin, \u03bcg\/liter, sham 31.8 + 1.8, OPX 33.7 + 2.7, PTX 24.5 + 2.1, O\/P 34.3 + 2.1, p &amp;lt; 0.025; alkaline phosphatase, U\/liter, sham 90 + 3, OPX 125 + 9, PTX 87 + 9, O\/P 116 + 11, p &amp;lt; 0.005). These data indicate postoophorectomy bone loss is not prevented by parathyroidectomy.<\/jats:p>","DOI":"10.1002\/jbmr.5650091204","type":"journal-article","created":{"date-parts":[[2010,2,3]],"date-time":"2010-02-03T16:16:16Z","timestamp":1265213776000},"page":"1859-1863","source":"Crossref","is-referenced-by-count":10,"title":["Parathyroidectomy does not prevent bone loss in the oophorectomized rat"],"prefix":"10.1093","volume":"9","author":[{"given":"N.A.","family":"Sims","sequence":"first","affiliation":[{"name":"Division of Clinical Biochemistry, Institute of Medical and Veterinary Science, and Department of Physiology, University of Adelaide, Adelaide, South Australia, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H.A.","family":"Dr. Morris","sequence":"additional","affiliation":[{"name":"Division of Clinical Biochemistry, Institute of Medical and Veterinary Science, and Department of Physiology, University of Adelaide, Adelaide, South Australia, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R.J.","family":"Moore","sequence":"additional","affiliation":[{"name":"Division of Tissue Pathology, Institute of Medical and Veterinary Science, Adelaide, South Australia, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"T.C.","family":"Durbridge","sequence":"additional","affiliation":[{"name":"Division of Tissue Pathology, Institute of Medical and Veterinary Science, Adelaide, South Australia, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[1994,12,1]]},"reference":[{"key":"2024013113132431800_bib1","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1007\/BF01880410","article-title":"Estrogens, bone loss and preservation","volume":"1","author":"Christiansen","year":"1990","journal-title":"Osteoporosis Int"},{"key":"2024013113132431800_bib2","first-page":"S157","article-title":"Intact serum PTH levels are higher 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