{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,2]],"date-time":"2026-04-02T01:06:00Z","timestamp":1775091960246,"version":"3.50.1"},"reference-count":43,"publisher":"Oxford University Press (OUP)","issue":"12","license":[{"start":{"date-parts":[[1994,12,1]],"date-time":"1994-12-01T00:00:00Z","timestamp":786240000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"name":"Ministry of Health and Welfare"},{"name":"Ministry of Education of Japan."}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[1994,12,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>To determine whether 24R,25-dihydroxyvitamin D3 [24R,25(OH)2D3] exerts unique biologic effects on bone, we examined the effects of the vitamin D metabolites, 24R,25(OH)2D3 and 1\u03b1,25-dihydroxyvitamin D3 [1\u03b1,25(OH)2D3], on the hypophosphatemic (Hyp) mouse, a model for X-linked hypophosphatemic rickets in humans. The Hyp mice were administered 1-10,000 \u03bcg\/kg\/day of 24R,25(OH)2D3, 0.01-10 (\u03bcg\/kg\/day of 1\u03b1,25(OH)2D3, or vehicle alone, given daily for 28 days by intraperitoneal injection. 24R,25(OH)2D3 at doses of 1-1000 \u03bcg\/kg\/day had dose-dependent effects in increasing bone size, dry bone weight, and bone mineral content without causing hypercalcemia. 1\u03b1,25(OH)2D3 at doses of 1 or 10 \u03bcg\/kg\/day, which we considered to have activity similar to that of 1000 \u03bcg\/kg\/day of 24R,25(OH)2D3 with respect to cell differentiation activity, caused severe bone resorption and hypercalcemia. At 0.1 \u03bcg\/kg\/day, 1\u03b1,25(OH)2D3 increased bone size, similarly to a dose of 1000 \u03bcg\/kg\/day of 24R,25(OH)2D3, without significantly affecting dry bone weight or bone mineral content, as did 1000 \u03bcg\/kg\/day of 24R,25(OH)2D3. These findings suggest that 24R,25(OH)2D3 exerts unique activity in the Hyp mouse rather than merely mimicking the activity of 1\u03b1,25(OH)2D3.<\/jats:p>","DOI":"10.1002\/jbmr.5650091217","type":"journal-article","created":{"date-parts":[[2010,2,3]],"date-time":"2010-02-03T16:16:16Z","timestamp":1265213776000},"page":"1967-1974","source":"Crossref","is-referenced-by-count":14,"title":["Bone-forming ability of 24<i>r<\/i>,25-dihydroxyvitamin d3 in the hypophosphatemic mouse"],"prefix":"10.1093","volume":"9","author":[{"given":"Tomoo","family":"Yamate","sequence":"first","affiliation":[{"name":"Department of Pediatrics, Okayama University Medical School, Okayama, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiroyuki","family":"Tanaka","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Okayama University Medical School, Okayama, 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