{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,7]],"date-time":"2026-04-07T11:32:29Z","timestamp":1775561549957,"version":"3.50.1"},"reference-count":29,"publisher":"Oxford University Press (OUP)","issue":"4","license":[{"start":{"date-parts":[[1995,4,1]],"date-time":"1995-04-01T00:00:00Z","timestamp":796694400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"name":"Merck Research Laboratories provided alendronate and placebo free of charge, plus support for normal volunteer costs"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[1995,4,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The bone loss and hypercalciuria induced by immobilization or the decreased gravitational forces of space are well described. Using a model of bedrest immobilization, the ability of a potent aminobisphosphonate, alendronate, to avert hypercalciuria and stone-forming propensity was tested. Sixteen male subjects participated in a randomized, placebo-controlled trial in which they received either 20 mg of alendronate or placebo 2 weeks prior to and during 3 weeks of strict bedrest. Parameters of bone and calcium metabolism and urinary crystallization of stone-forming salts were measured before and at the end of bedrest. In the placebo group, bedrest increased urinary calcium (209 \u00b1 47 to 267 \u00b1 60 mg\/day, p &amp;lt; 0.01) and the saturation of calcium phosphate. Before bedrest, the alendronate group had a significantly lower serum calcium (8.8 \u00b1 0.4 vs. 9.6 \u00b1 0.5 mg\/dl, p \u2265 0.01) and higher serum PTH (62.4 \u00b1 33.1 vs. 23.1 \u00b1 7.5 pg\/ml, p &amp;gt; 0.01) compared with the placebo group. Moreover, the alendronate group had a lower urinary calcium (75 \u00b1 41 mg\/day) and saturation of calcium oxalate and calcium phosphate. These effects of alendronate were sustained during bedrest. Following bedrest in the alendronate group, urinary calcium rose to 121 \u00b1 50 mg\/day, a value less than that in the placebo group before or during bedrest. Similarly, urinary saturation of calcium oxalate and calcium phosphate rose with bedrest in the alendronate-treated patients but remained lower than values obtained in placebo-treated patients before or during bedrest. Alendronate inhibits bone mineral loss and averts the hypercalciuria and increased propensity for the crystallization of stone-forming calcium salts which occurs during 3 weeks of strict bedrest.<\/jats:p>","DOI":"10.1002\/jbmr.5650100420","type":"journal-article","created":{"date-parts":[[2010,2,3]],"date-time":"2010-02-03T16:07:00Z","timestamp":1265213220000},"page":"655-662","source":"Crossref","is-referenced-by-count":58,"title":["Prevention of hypercalciuria and stone-forming propensity during prolonged bedrest by alendronate"],"prefix":"10.1093","volume":"10","author":[{"given":"Lisa A.","family":"Ruml","sequence":"first","affiliation":[{"name":"The Center for Mineral Metabolism and Clinical Research, University of Texas Southwestern Medical Center, Dallas, Texas"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Susan K.","family":"Dubois","sequence":"additional","affiliation":[{"name":"The Center for Mineral Metabolism and Clinical Research, University of Texas Southwestern Medical Center, Dallas, Texas"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marsha L.","family":"Roberts","sequence":"additional","affiliation":[{"name":"The Center for Mineral Metabolism and Clinical Research, University of Texas Southwestern Medical Center, Dallas, Texas"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Charles Y.C.","family":"Pak","sequence":"additional","affiliation":[{"name":"The Center for Mineral Metabolism and Clinical Research, University of Texas Southwestern Medical Center, Dallas, Texas"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[1995,4,1]]},"reference":[{"key":"2024013114202826200_bib1","doi-asserted-by":"crossref","first-page":"1071","DOI":"10.1016\/0026-0495(70)90032-6","article-title":"Effect of prolonged bedrest on bone 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