{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T02:11:54Z","timestamp":1791425514432,"version":"4.3.3"},"reference-count":25,"publisher":"Oxford University Press (OUP)","issue":"12","license":[{"start":{"date-parts":[[1995,12,1]],"date-time":"1995-12-01T00:00:00Z","timestamp":817776000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[1995,12,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>The epidemiologic patterns of vertebral and femoral fractures are sufficiently different to suggest that they represent distinct disorders (type I versus type II osteoporosis) although osteopenia is common in both. To determine whether differences in femoral geometry, one of the main determinants of bone quality, might contribute to the heterogeneity in osteoporotic fractures, we obtained dual energy X-ray absorptiometry scans on 210 women age 60 or older, including 105 type 1 fracture cases, 30 type II patients, and 75 controls. Hip axis length, measured on the scan printout, was significantly increased (p &amp;lt; 0.01) in hip fracture patients compared with women with postmenopausal osteoporosis, whereas femoral neck density (BMD) was equal in both groups. The best discrimination between both fracture types was obtained by a logistic regression model based on age and axis length. Adding BMD to the model did not improve the discriminative power (p = 0.67). These data provide further evidence that geometric characteristics may be implicated in hip fracture risk. Furthermore, these findings suggest that an increase in hip axis length may predispose osteopenic subjects to a femoral localization of fragility fractures, consistent with the postulated heterogeneity in the pathogenesis of osteoporotic fractures.<\/jats:p>","DOI":"10.1002\/jbmr.5650101210","type":"journal-article","created":{"date-parts":[[2010,2,3]],"date-time":"2010-02-03T16:02:57Z","timestamp":1265212977000},"page":"1908-1912","source":"Crossref","is-referenced-by-count":65,"title":["Measurement of femoral geometry in type I and type II osteoporosis: Differences in hip axis length consistent with heterogeneity in the pathogenesis of osteoporotic fractures"],"prefix":"10.1093","volume":"10","author":[{"given":"Steven","family":"Boonen","sequence":"first","affiliation":[{"name":"Division of Geriatric Medicine, Katholieke Universiteit Leuven, Belgium"},{"name":"Arthritis and Metabolic Bone Disease Research Unit, Katholieke Universiteit Leuven, Pellenberg, Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rosetta","family":"Koutri","sequence":"additional","affiliation":[{"name":"Arthritis and Metabolic Bone Disease Research Unit, Katholieke Universiteit Leuven, Pellenberg, Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jan","family":"Dequeker","sequence":"additional","affiliation":[{"name":"Division of Rheumatology, Katholieke Universiteit Leuven, Pellenberg, Belgium"},{"name":"Arthritis and Metabolic Bone Disease Research Unit, Katholieke Universiteit Leuven, Pellenberg, Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeroen","family":"Aerssens","sequence":"additional","affiliation":[{"name":"Arthritis and Metabolic Bone Disease Research Unit, Katholieke Universiteit Leuven, Pellenberg, Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Geert","family":"Lowet","sequence":"additional","affiliation":[{"name":"Division of Biomechanics and Engineering Design, Katholieke Universiteit Leuven, Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jos","family":"Nijs","sequence":"additional","affiliation":[{"name":"Arthritis and Metabolic Bone Disease Research Unit, Katholieke Universiteit Leuven, Pellenberg, Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Geert","family":"Verbeke","sequence":"additional","affiliation":[{"name":"Department of Epidemiology, Biostatistical Centre and the Department of Internal Medicine, Katholieke Universiteit Leuven, Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emmanuel","family":"Lesaffre","sequence":"additional","affiliation":[{"name":"Department of Epidemiology, Biostatistical Centre and the Department of Internal Medicine, Katholieke Universiteit Leuven, Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Piet","family":"Geusens","sequence":"additional","affiliation":[{"name":"Division of Rheumatology, Katholieke Universiteit Leuven, Pellenberg, Belgium"},{"name":"Arthritis and Metabolic Bone Disease Research Unit, Katholieke Universiteit Leuven, Pellenberg, Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[1995,12,1]]},"reference":[{"key":"2024013113140642100_bib1","doi-asserted-by":"crossref","first-page":"899","DOI":"10.1016\/0002-9343(83)90860-4","article-title":"Evidence for two distinct syndromes of involutional osteoporosis","volume":"75","author":"Riggs","year":"1983","journal-title":"Am J Med"},{"key":"2024013113140642100_bib2","doi-asserted-by":"crossref","first-page":"1676","DOI":"10.1056\/NEJM198606263142605","article-title":"Involutional osteoporosis","volume":"314","author":"Riggs","year":"1986","journal-title":"New Engl J Med"},{"key":"2024013113140642100_bib3","doi-asserted-by":"crossref","first-page":"599","DOI":"10.1002\/jbmr.5650090503","article-title":"Risk of hip fracture in women with vertebral fracture","volume":"9","author":"Kotowicz","year":"1994","journal-title":"J Bone Miner Res"},{"key":"2024013113140642100_bib4","doi-asserted-by":"crossref","first-page":"S23","DOI":"10.1007\/BF01673397","article-title":"The epidemiology of fragility fractures: Is there a role for bone quality?","volume":"53","author":"Cooper","year":"1993","journal-title":"Calcif Tissue Int"},{"issue":"Suppl 2","key":"2024013113140642100_bib5","doi-asserted-by":"crossref","first-page":"S437","DOI":"10.1002\/jbmr.5650071414","article-title":"Effect of bone size, not density, on the stiffness of the proximal part of normal and osteoporotic human femora","volume":"7","author":"Cordey","year":"1992","journal-title":"J Bone Miner Res"},{"key":"2024013113140642100_bib6","doi-asserted-by":"crossref","first-page":"S3","DOI":"10.1007\/BF01673394","article-title":"Is there a role for bone quality in fragility fractures?","volume":"53","author":"Heaney","year":"1993","journal-title":"Calcif Tissue Int"},{"key":"2024013113140642100_bib7","doi-asserted-by":"crossref","first-page":"S34","DOI":"10.1007\/BF01673400","article-title":"Aging and strength of bone as a structural material","volume":"53","author":"Martin","year":"1993","journal-title":"Calcif Tissue Int"},{"key":"2024013113140642100_bib8","doi-asserted-by":"crossref","first-page":"671","DOI":"10.1002\/jbmr.5650090512","article-title":"Prediction of hip fractures from pelvic radiographs: The study of osteoporotic fractures","volume":"9","author":"Gl\u00fcer","year":"1994","journal-title":"J Bone Miner Res"},{"key":"2024013113140642100_bib9","doi-asserted-by":"crossref","first-page":"1211","DOI":"10.1002\/jbmr.5650081008","article-title":"Simple measurement of femoral geometry predicts hip fracture: The Study of Osteoporotic Fractures","volume":"10","author":"Faulkner","year":"1993","journal-title":"J Bone Miner Res"},{"key":"2024013113140642100_bib10","doi-asserted-by":"crossref","first-page":"S41","DOI":"10.1007\/BF01673401","article-title":"Age-related changes in female femoral neck geometry: Implications for bone strength","volume":"53","author":"Beck","year":"1993","journal-title":"Calcif Tissue Int"},{"key":"2024013113140642100_bib11","first-page":"16","volume-title":"Current Research in Osteoporosis and Bone Mineral Measurements","author":"Silman","year":"1994"},{"key":"2024013113140642100_bib12","doi-asserted-by":"crossref","first-page":"M107","DOI":"10.1093\/geronj\/44.4.M107","article-title":"A hypothesis: The causes of hip fractures","volume":"44","author":"Cummings","year":"1989","journal-title":"J Gerontol"},{"key":"2024013113140642100_bib13","doi-asserted-by":"crossref","first-page":"689","DOI":"10.2106\/00004623-199072050-00008","article-title":"The use of quantitative computed tomography to estimate risk of fracture of the hip from falls","volume":"72","author":"Lotz","year":"1990","journal-title":"J Bone Joint Surg"},{"key":"2024013113140642100_bib14","doi-asserted-by":"crossref","first-page":"1326","DOI":"10.1056\/NEJM199105093241905","article-title":"Risk factors for falls as a cause of hip fracture in women","volume":"324","author":"Grisso","year":"1991","journal-title":"New Engl J Med"},{"key":"2024013113140642100_bib15","doi-asserted-by":"crossref","first-page":"192","DOI":"10.1007\/BF00298717","article-title":"Impact near the hip dominates fracture risk in elderly nursing home residents who fall","volume":"52","author":"Hayes","year":"1993","journal-title":"Calcif Tissue Int"},{"key":"2024013113140642100_bib16","doi-asserted-by":"crossref","first-page":"1226","DOI":"10.1111\/j.1532-5415.1993.tb07307.x","article-title":"Type of fall and risk of hip and wrist fractures: The study of osteoporotic fractures","volume":"41","author":"Nevitt","year":"1993","journal-title":"J Am Geriatr Soc"},{"key":"2024013113140642100_bib17","doi-asserted-by":"crossref","first-page":"698","DOI":"10.1302\/0301-620X.56B4.698","article-title":"The role of fatigue in the pathogenesis of senile femoral neck fractures","volume":"56","author":"Freeman","year":"1974","journal-title":"J Bone Joint Surg"},{"key":"2024013113140642100_bib18","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1016\/0221-8747(82)90021-2","article-title":"Histomorphometric profile and vitamin D status in patients with femoral neck fracture","volume":"4","author":"Lips","year":"1982","journal-title":"Metab Bone Dis Rel Res"},{"key":"2024013113140642100_bib19","first-page":"178","article-title":"Osteon morphometry in females with femoral neck fractures","volume":"283","author":"Barth","year":"1990","journal-title":"Clin J Orthop Rel Res"},{"key":"2024013113140642100_bib20","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1007\/BF00296651","article-title":"Videodensitometry of osteons in females with femoral neck fractures","volume":"52","author":"Squillante","year":"1993","journal-title":"Calcif Tissue Int"},{"key":"2024013113140642100_bib21","doi-asserted-by":"crossref","first-page":"1193","DOI":"10.2106\/00004623-199308000-00009","article-title":"Age-related changes in the tensile properties of cortical bone","volume":"75","author":"McCalden","year":"1993","journal-title":"J Bone Joint Surg"},{"key":"2024013113140642100_bib22","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1097\/00003086-199103000-00018","article-title":"Osteoarthritis retards the development of osteoporosis","volume":"264","author":"Verstraeten","year":"1991","journal-title":"Clin Orthop"},{"key":"2024013113140642100_bib23","doi-asserted-by":"crossref","first-page":"S51","DOI":"10.1016\/8756-3282(93)90350-J","article-title":"Osteoarthritis protects against femoral neck fracture: The MEDOS Study Experience","volume":"14","author":"Dequeker","year":"1993","journal-title":"Bone"},{"issue":"Suppl 1","key":"2024013113140642100_bib24","first-page":"38","article-title":"The effect of osteoporosis on the mechanical properties of bone structures","volume":"13","author":"Van Audekercke","year":"1994","journal-title":"Clin Rheumatol"},{"key":"2024013113140642100_bib25","doi-asserted-by":"crossref","first-page":"506","DOI":"10.1002\/jbmr.5650100323","article-title":"Hip axis length and osteoporotic fractures","volume":"10","author":"Faulkner","year":"1995","journal-title":"J Bone Miner Res"}],"container-title":["Journal of Bone and Mineral Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fjbmr.5650101210","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/academic.oup.com\/jbmr\/article-pdf\/10\/12\/1908\/56499887\/5650101210.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/jbmr\/article-pdf\/10\/12\/1908\/56499887\/5650101210.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,3,13]],"date-time":"2024-03-13T15:01:36Z","timestamp":1710342096000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/jbmr\/article\/10\/12\/1908-1912\/7500575"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1995,12,1]]},"references-count":25,"journal-issue":{"issue":"12","published-online":{"date-parts":[[1995,12,1]]},"published-print":{"date-parts":[[1995,12,1]]}},"URL":"https:\/\/doi.org\/10.1002\/jbmr.5650101210","relation":{},"ISSN":["0884-0431","1523-4681"],"issn-type":[{"value":"0884-0431","type":"print"},{"value":"1523-4681","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[1995,12,1]]},"published":{"date-parts":[[1995,12,1]]}}}