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Group 1 was the basal control. Group 2 was the nontreated control. Groups 3\u20137 were given prednisolone at 30 mg\/kg of body weight (BW) twice a week and concomitantly administered ED-71 with respective doses of 0, 0.0125, 0.025, 0.05, and 0.1 \u03bcg\/kg of BW for 12 weeks. In group 3, urinary calcium (U-Ca) and deoxypyridinoline (U-Dpy) were significantly increased compared with group 2. In groups 4\u20137, U-Ca values were increased but U-Dpy values were dose-dependently decreased. Age-dependent increases in the parameter values of BMD, compressive strength, trabecular bone volume (BV\/TV), and trabecular thickness (Tb.Th) of the lumbar body were significantly suppressed in group 3 but dose-dependently increased in groups 4\u20137, and the values of group 7 exceeded those of group 2. The parameters of bone mineral density (BMD) and the bending strength of the femur in groups 4\u20137 were larger than the values in group 3 but did not reach the levels of group 2. The trabecular bone formation rate (BFR\/BS) of the lumbar body measured by calcein labeling in group 3 was reduced when compared with group 2, but the values were not further decreased in groups 4\u20137. The perimeter ratios of double labels over single labels (dLS\/sLS) greatly decreased by prednisolone, were dose-dependently increased to the level of the normal control by ED-71. Double-labeled perimeters and the dLS\/sLS ratios were also increased in the periosteal envelope of the midfemur. These findings clearly demonstrate that prednisolone administration affects the age-related changes in bone metabolism, and ED-71 administration counteracts the effects by increasing intestinal calcium absorption, reducing bone resorption, and enhancing mineralization. The action of ED-71, however, seems to be less potent in the cortical bone.<\/jats:p>","DOI":"10.1002\/jbmr.5650110306","type":"journal-article","created":{"date-parts":[[2010,2,3]],"date-time":"2010-02-03T15:31:40Z","timestamp":1265211100000},"page":"325-336","source":"Crossref","is-referenced-by-count":42,"title":["Effects of a synthetic vitamin D analog, ED-71, on bone dynamics and strength in cancellous and cortical bone in prednisolone-treated rats"],"prefix":"10.1093","volume":"11","author":[{"given":"Yuzo","family":"Tanaka","sequence":"first","affiliation":[{"name":"Department of Orthopedic Surgery, School of Medicine, University of Occupational and Environmental Health, Kitakyushu, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Toshitaka","family":"Dr. Nakamura","sequence":"additional","affiliation":[{"name":"Department of Orthopedic Surgery, School of Medicine, University of Occupational and Environmental Health, Kitakyushu, 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