{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,24]],"date-time":"2026-07-24T00:11:33Z","timestamp":1784851893409,"version":"3.55.0"},"reference-count":40,"publisher":"Oxford University Press (OUP)","issue":"10","license":[{"start":{"date-parts":[[1996,10,1]],"date-time":"1996-10-01T00:00:00Z","timestamp":844128000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"name":"NIH","award":["AG10358"],"award-info":[{"award-number":["AG10358"]}]},{"name":"NIH","award":["UO1-AG10373"],"award-info":[{"award-number":["UO1-AG10373"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[1996,10,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Calcium absorption declines with age. Because 1,25-dihydroxyvitamin D (1,25(OH)2D) is the major hormone controlling calcium absorption, changes in vitamin D metabolism may account for the malabsorption of aging. Serum levels of 1,25(OH)2D have been reported to either decrease or remain unchanged with age. To assess the effect of aging on renal production of 1,25(OH)2D, we evaluated the response of renal 25OHD 1\u03b1 hydroxylase to human parathyroid hormone (hPTH(1-34) stimulation in 119 women ages 25-83 years. In this population, baseline serum 25OHD and 1,25(OH)2D values did not significantly change with age, but serum iPTH (r = 0.44; p &amp;lt; 0.001) and serum creatinine (r = 0.31; p &amp;lt; 0.01) increased with age. However, the stimulatory activity of hPTH(1-34) on the renal production of 1,25(OH)2D declined with age (r3 = -0.36; p &amp;lt; 0.001) and was most apparent after age 75, being 50% less than that of younger women. Besides age, the production of 1,25(OH)2D was found to be dependent on baseline serum iPTH (r = -0.31; p &amp;lt; 0.0001). Administration of hPTH(1-34) led to suppression of endogenous PTH, and suppressibility of endogenous PTH declined with age (r = 0.53; p &amp;lt; 0.0001). The increase in serum PTH and decreased suppressibility of PTH with age could be due to mild secondary hyperparathyroidism. The increase in PTH with age is probably responsible for maintaining normal serum 1,25(OH)2D levels in elderly subjects; however, decreased metabolism of 1,25(OH)2D in the elderly could also maintain normal serum 1,25(OH)2D levels.<\/jats:p>","DOI":"10.1002\/jbmr.5650111005","type":"journal-article","created":{"date-parts":[[2010,2,3]],"date-time":"2010-02-03T15:29:16Z","timestamp":1265210956000},"page":"1400-1405","source":"Crossref","is-referenced-by-count":27,"title":["Effect of parathyroid hormone (hPTH[1-34]) infusion on serum 1,25-dihydroxyvitamin D and parathyroid hormone in normal women"],"prefix":"10.1093","volume":"11","author":[{"given":"H. Karimi","family":"Kinyamu","sequence":"first","affiliation":[{"name":"Bone Metabolism Unit, Creighton University School of Medicine, Omaha, Nebraska, U.S.A"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J. Christopher","family":"Gallagher","sequence":"additional","affiliation":[{"name":"Bone Metabolism Unit, Creighton University School of Medicine, Omaha, Nebraska, U.S.A"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kimberly M.","family":"Petranick","sequence":"additional","affiliation":[{"name":"Bone Metabolism Unit, Creighton University School of Medicine, Omaha, Nebraska, U.S.A"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kay L.","family":"Ryschon","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Creighton University School of Medicine, Omaha, Nebraska, U.S.A"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[1996,10,1]]},"reference":[{"key":"2024013114274816300_bib1","doi-asserted-by":"crossref","first-page":"1676","DOI":"10.1056\/NEJM198606263142605","article-title":"Involutional osteoporosis.","volume":"26","author":"Riggs","year":"1986","journal-title":"New Engl J Med"},{"key":"2024013114274816300_bib2","doi-asserted-by":"crossref","first-page":"729","DOI":"10.1172\/JCI109516","article-title":"Intestinal calcium absorption and serum vitamin D metabolites in normal subjects and osteoporotic patients.","volume":"64","author":"Gallagher","year":"1979","journal-title":"J Clin Invest"},{"key":"2024013114274816300_bib3","doi-asserted-by":"crossref","first-page":"535","DOI":"10.1016\/S0140-6736(70)91344-9","article-title":"Effect of age on calcium absorption.","volume":"2","author":"Bullamore","year":"1970","journal-title":"Lancet"},{"key":"2024013114274816300_bib4","doi-asserted-by":"crossref","first-page":"442","DOI":"10.1007\/BF02546491","article-title":"Calcium absorption in the elderly. 11th Symposium on Calcified Tissues.","volume":"215","author":"Nordin","year":"1975","journal-title":"Calcif Tissue Res"},{"key":"2024013114274816300_bib5","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1002\/jbmr.5650060205","article-title":"Interrelationship among vitamin D metabolism, true calcium absorption, parathyroid function, and age in women: Evidence of an age-related intestinal resistance to 1,25-dihydroxyvitamin D action.","volume":"6","author":"Eastell","year":"1991","journal-title":"J Bone Miner Res"},{"key":"2024013114274816300_bib6","doi-asserted-by":"crossref","first-page":"751","DOI":"10.1210\/jcem-56-4-751","article-title":"The cytoreceptor assay for 1,25-dihydroxyvitamin D and its application to clinical studies.","volume":"56","author":"Manolagas","year":"1983","journal-title":"J Clin Endocrinol Metab"},{"key":"2024013114274816300_bib7","doi-asserted-by":"crossref","first-page":"1668","DOI":"10.1172\/JCI111373","article-title":"Impaired vitamin D metabolism with aging in women.","volume":"73","author":"Tsai","year":"1984","journal-title":"J Clin Invest"},{"key":"2024013114274816300_bib8","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/BF02555161","article-title":"Effect of declining renal function on bone density in aging women.","volume":"43","author":"Buchanan","year":"1988","journal-title":"Calcif Tissue Int"},{"key":"2024013114274816300_bib9","doi-asserted-by":"crossref","first-page":"656","DOI":"10.1210\/jcem-63-3-656","article-title":"Serum vitamin D2 and vitamin D3 metabolite concentrations and absorption of vitamin D2 in elderly subjects.","volume":"63","author":"Clemens","year":"1986","journal-title":"J Clin Endocrinol Metab"},{"key":"2024013114274816300_bib10","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1007\/BF02405289","article-title":"Serum vitamin D metabolites in younger and elderly postmenopausal women.","volume":"36","author":"Christiansen","year":"1984","journal-title":"Calcif Tissue Int"},{"key":"2024013114274816300_bib11","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1016\/8756-3282(86)90001-3","article-title":"The influence of age on bone mineral regulating hormones.","volume":"7","author":"Epstein","year":"1986","journal-title":"Bone"},{"key":"2024013114274816300_bib12","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1210\/jcem-71-2-405","article-title":"Vitamin D status and related parameters in a healthy population: The effects of age, sex, and season.","volume":"71","author":"Sherman","year":"1990","journal-title":"J Clin Endocrinol Metab"},{"key":"2024013114274816300_bib13","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1016\/0221-8747(78)90033-4","article-title":"The effect of age on calcium absorption and accumulation of 1,25-dihydroxyvitamin D3 in intestinal mucosa of rats.","volume":"1","author":"Horst","year":"1978","journal-title":"Metab Bone Dis Relat Res"},{"key":"2024013114274816300_bib14","doi-asserted-by":"crossref","first-page":"1118","DOI":"10.1172\/JCI109941","article-title":"Effect of age on the conversion of 25-hydroxyvitamin D3 by kidney of rat.","volume":"66","author":"Armbrecht","year":"1980","journal-title":"J Clin Invest"},{"key":"2024013114274816300_bib15","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1093\/ageing\/13.1.14","article-title":"Renal impairment and its effects on calcium metabolism in elderly women.","volume":"13","author":"Francis","year":"1984","journal-title":"Age Aging"},{"key":"2024013114274816300_bib16","first-page":"373","article-title":"The effect of age on serum immunoreactive parathyroid hormone in normal and osteoporotic women.","volume":"95","author":"Gallagher","year":"1980","journal-title":"J Lab Clin Med"},{"key":"2024013114274816300_bib17","doi-asserted-by":"crossref","first-page":"1072","DOI":"10.1210\/jcem-53-5-1072","article-title":"Effect of age on serum immunoreactive parathyroid hormone and its biological effects.","volume":"53","author":"Insogna","year":"1981","journal-title":"J Clin Endocrinol Metab"},{"key":"2024013114274816300_bib18","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1210\/jcem-58-2-223","article-title":"Age related changes in parathyroid hormone and parathyroid hormone action in normal humans.","volume":"58","author":"Marcus","year":"1984","journal-title":"J Clin Endocrinol Metab"},{"key":"2024013114274816300_bib19","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1093\/geronj\/38.1.19","article-title":"Age-related changes in parathyroid hormone and 25 hydroxycholecalciferol levels.","volume":"38","author":"Chapuy","year":"1983","journal-title":"J Gerontol"},{"key":"2024013114274816300_bib20","doi-asserted-by":"crossref","first-page":"931","DOI":"10.1016\/S0140-6736(79)92624-2","article-title":"Modulation of plasma 1,25-dihydroxyvitamin D in man by stimulation and suppression tests.","volume":"2","author":"Eisman","year":"1979","journal-title":"Lancet"},{"key":"2024013114274816300_bib21","doi-asserted-by":"crossref","first-page":"372","DOI":"10.1056\/NEJM198108133050704","article-title":"Deficient production of 1,25-dihydroxyvitamin D in elderly osteoporotie patients.","volume":"305","author":"Slovik","year":"1981","journal-title":"New Engl J Med"},{"key":"2024013114274816300_bib22","doi-asserted-by":"crossref","first-page":"833","DOI":"10.1210\/jcem-53-4-833","article-title":"Assessment of 25-hydroxyvitamin D 1\u03b1-hydroxylase reserve in postmenopausal osteoporosis by administration of parathyroid extract.","volume":"53","author":"Riggs","year":"1981","journal-title":"J Clin Endocrinol Metab"},{"key":"2024013114274816300_bib23","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1016\/0169-6009(90)90080-Y","article-title":"Biochemical responses to sequential human parathyroid hormone (1\u201338) and calcitonin in osteoporotic patients.","volume":"9","author":"Hodsman","year":"1990","journal-title":"Bone Miner"},{"key":"2024013114274816300_bib24","doi-asserted-by":"crossref","first-page":"992","DOI":"10.1210\/jcem-33-6-992","article-title":"Competitive protein-binding radio-assay for 25-hydroxycholecalciferol.","volume":"33","author":"Haddad","year":"1971","journal-title":"J Clin Endocr"},{"key":"2024013114274816300_bib25","doi-asserted-by":"crossref","first-page":"720","DOI":"10.1515\/9783110846713.720","volume-title":"Vitamin D: Molecular, Cellular and Clinical Endocrinology","author":"Reinhardt","year":"1988"},{"key":"2024013114274816300_bib26","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1210\/jcem-58-1-91","article-title":"A microassay for 1,25-dihydroxyvitamin D not requiring high performance liquid chromatography: application to clinical studies.","volume":"58","author":"Reinhardt","year":"1984","journal-title":"J Clin Endocrinol Metab"},{"key":"2024013114274816300_bib27","doi-asserted-by":"crossref","first-page":"2060","DOI":"10.1093\/clinchem\/32.11.2060","article-title":"Assay of circulating 1,25-dihydroxyvitamin D involving a novel single-cartridge extraction and purification procedure.","volume":"32","author":"Hollis","year":"1986","journal-title":"Clin Chem"},{"key":"2024013114274816300_bib28","doi-asserted-by":"crossref","first-page":"1364","DOI":"10.1093\/clinchem\/33.8.1364","article-title":"Highly sensitive two-site immunoradiometric assay of parathyrin, and its clinical utility in evaluating patients with hypercalcemia.","volume":"33","author":"Nussbaum","year":"1987","journal-title":"Clin Chem"},{"key":"2024013114274816300_bib29","first-page":"E338","article-title":"Influence of estrogen on renal vitamin D hydroxylases and serum 1 \u03b1,25-(OH)2D3 in chicks.","volume":"235","author":"Pike","year":"1978","journal-title":"Am J Physiol"},{"key":"2024013114274816300_bib30","first-page":"E626","article-title":"Renal cAMP and 1,25(OH)2D3 synthesis in estrogen-treated chick embryos and hens.","volume":"249","author":"Martz","year":"1985","journal-title":"Am J Physiol"},{"key":"2024013114274816300_bib31","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1016\/0003-9861(77)90105-9","article-title":"The stimulation of 25-hydroxyvitamin D3-1\u03b1-hydroxylase by estrogen.","volume":"179","author":"Castillo","year":"1977","journal-title":"Arch Biochem Biophys"},{"key":"2024013114274816300_bib32","doi-asserted-by":"crossref","first-page":"877","DOI":"10.1002\/jbmr.5650050812","article-title":"Effects of estrogen on daylong circulating calcium, phosphorus, 1,25-dihydroxyvitamin D, and parathyroid hormone in postmenopausal women.","volume":"5","author":"Packer","year":"1990","journal-title":"J Bone Miner Res"},{"key":"2024013114274816300_bib33","doi-asserted-by":"crossref","first-page":"1359","DOI":"10.1210\/jcem-51-6-1359","article-title":"Effect of estrogen on calcium absorption and serum vitamin D metabolites in postmenopausal osteoporosis.","volume":"51","author":"Gallagher","year":"1980","journal-title":"J Clin Endocrinol Metab"},{"key":"2024013114274816300_bib34","doi-asserted-by":"crossref","first-page":"537","DOI":"10.1172\/JCI113915","article-title":"Effects of estrogen on circulating \u201cfree\u201d and total 1,25-dihydroxyvitamin D and on the parathyroid vitamin D axis in postmenopausal women.","volume":"83","author":"Cheema","year":"1989","journal-title":"J Clin Invest"},{"key":"2024013114274816300_bib35","doi-asserted-by":"crossref","first-page":"953","DOI":"10.1016\/0006-291X(91)90984-F","article-title":"Direct inhibitory effect of amino-terminal parathyroid hormone fragment [PTH(1\u201334)] on PTH secretion from bovine parathyroid primary cultured cells in vitro.","volume":"178","author":"Fujimi","year":"1991","journal-title":"Biochem Biophys Res Commun"},{"key":"2024013114274816300_bib36","first-page":"1535","article-title":"Subcutaneous administration of the amino-terminal fragment of human parathyroid hormone-(1\u201334): Kinetics and biochemical response in estrogenized osteoporotic patients.","volume":"77","author":"Lindsay","year":"1993","journal-title":"J Clin Endocrinol Metab"},{"key":"2024013114274816300_bib37","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1210\/jcem-54-1-172","article-title":"Abnormal regulation of parathyroid hormone release by calcium in secondary hyperparathyroidism due to chronic renal failure.","volume":"54","author":"Brown","year":"1982","journal-title":"J Clin Endocrinol Metab"},{"key":"2024013114274816300_bib38","first-page":"1489","article-title":"Direct in vivo comparison of calcium-regulated parathyroid hormone secretion in normal volunteers and patients with secondary hyperparathyroidism.","volume":"76","author":"Ramirez","year":"1993","journal-title":"J Clin Endocrinol Metab"},{"key":"2024013114274816300_bib39","doi-asserted-by":"crossref","first-page":"835","DOI":"10.1002\/jbmr.5650100602","article-title":"The effects of menopause and age on calcitropic hormones: A cross sectional study of 655 healthy women aged 35\u201390.","volume":"10","author":"Prince","year":"1995","journal-title":"J Bone Miner Res"},{"key":"2024013114274816300_bib40","first-page":"211","article-title":"Abnormalities of parathyroid hormone secretion in elderly women that are reversible by short term therapy with 1,25-dihydroxyvitamin D3.","volume":"79","author":"Ledger","year":"1994","journal-title":"J Clin Endocrinol Metab"}],"container-title":["Journal of Bone and Mineral Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fjbmr.5650111005","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/academic.oup.com\/jbmr\/article-pdf\/11\/10\/1400\/56503883\/5650111005.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/jbmr\/article-pdf\/11\/10\/1400\/56503883\/5650111005.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,3,13]],"date-time":"2024-03-13T15:03:32Z","timestamp":1710342212000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/jbmr\/article\/11\/10\/1400-1405\/7501264"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1996,10,1]]},"references-count":40,"journal-issue":{"issue":"10","published-online":{"date-parts":[[1996,10,1]]},"published-print":{"date-parts":[[1996,10,1]]}},"URL":"https:\/\/doi.org\/10.1002\/jbmr.5650111005","relation":{},"ISSN":["0884-0431","1523-4681"],"issn-type":[{"value":"0884-0431","type":"print"},{"value":"1523-4681","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[1996,10,1]]},"published":{"date-parts":[[1996,10,1]]}}}