{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,12]],"date-time":"2026-06-12T08:39:12Z","timestamp":1781253552666,"version":"3.54.1"},"reference-count":20,"publisher":"Oxford University Press (OUP)","issue":"12","license":[{"start":{"date-parts":[[1996,12,1]],"date-time":"1996-12-01T00:00:00Z","timestamp":849398400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"name":"NIA"},{"DOI":"10.13039\/100031147","name":"Claude D. Pepper Older Americans Independence Center","doi-asserted-by":"crossref","award":["#5 P60 AG11268"],"award-info":[{"award-number":["#5 P60 AG11268"]}],"id":[{"id":"10.13039\/100031147","id-type":"DOI","asserted-by":"crossref"}]},{"name":"NICHHD","award":["#5 R01 HD30442"],"award-info":[{"award-number":["#5 R01 HD30442"]}]},{"name":"VA Medical Research Service."}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[1996,12,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Little is known about how Paget's disease of bone affects quality of life. To better understand the relative impact of factors on quality of life, we mailed a brief survey to 2000 people randomly selected from the Paget's Foundation mailing list. The sample was geographically stratified to examine the effects of specialist availability. Nine hundred and fifty-eight persons responded to the questionnaire (53% response rate after adjustment for death, incorrect addresses, and nondeliverable mailings). The sample had equal proportions of males and females, with a mean age of 74 years (SD = 9.0). Most (97%) were white, with high levels of education (mean 13 years; SD 3.7) and income (60% earned more than $20,000 annually). They reported pagetic bone in the skull (34%), spine (35%), pelvis (49%), and leg (48%). The most frequently mentioned complications were hearing loss (37%) and bowed limbs (31%). Comorbidity included arthritis (64%), hypertension (32%), and heart problems (28%). Nearly half (47%) reported feelings of depression, and 42% said that their health was fair or poor. Only 21% reported that quality of life was very good or excellent. In multiple partial F-test regression analyses, variables were divided into four domains (social, psychological, care, and biomedical). The psychological domain explained 19% of the variance beyond that explained by all other variables; the social domain explained 3%, the biomedical domain explained 3% and the care domain explained 1%. The importance of the psychological aspects of Paget's disease suggests that treatment protocols should include psychological intervention to improve quality of life.<\/jats:p>","DOI":"10.1002\/jbmr.5650111210","type":"journal-article","created":{"date-parts":[[2010,2,24]],"date-time":"2010-02-24T19:48:52Z","timestamp":1267040932000},"page":"1897-1904","source":"Crossref","is-referenced-by-count":64,"title":["Paget's disease of bone and quality of life"],"prefix":"10.1093","volume":"11","author":[{"given":"Deborah T.","family":"Gold","sequence":"first","affiliation":[{"name":"Center for the Study of Aging and Human Development, Duke University Medical Center, Durham, North Carolina, U.S.A."},{"name":"Departments of Psychiatry and Behavioral Sciences and Sociology, Duke University Medical Center, Durham, North Carolina, U.S.A."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jennifer","family":"Boisture","sequence":"additional","affiliation":[{"name":"Center for the Study of Aging and Human Development, Duke University Medical Center, Durham, North Carolina, U.S.A."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kathy M.","family":"Shipp","sequence":"additional","affiliation":[{"name":"Department of Physical Therapy, Duke University Medical Center, Durham, North Carolina, U.S.A."},{"name":"Center for the Study of Aging and Human Development, Duke University Medical Center, Durham, North Carolina, U.S.A."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carl F.","family":"Pieper","sequence":"additional","affiliation":[{"name":"Department of Community and Family Medicine, Duke University Medical Center, Durham, North Carolina, U.S.A."},{"name":"Center for the Study of Aging and Human Development, Duke University Medical Center, Durham, North Carolina, U.S.A."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kenneth W.","family":"Lyles","sequence":"additional","affiliation":[{"name":"The GRECC, VMAC, Durham, North Carolina, U.S.A."},{"name":"Department of Medicine, Duke University Medical Center, Durham, North Carolina, U.S.A."},{"name":"Center for the Study of Aging and Human Development, Duke University Medical Center, Durham, North Carolina, U.S.A."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[1996,12,1]]},"reference":[{"key":"2024013114273409300_bib1","doi-asserted-by":"crossref","first-page":"594","DOI":"10.2165\/00003495-199346040-00003","article-title":"Drugs used in the treatment of metabolic bone disease: Clinical pharmacology and therapeutic use","volume":"46","author":"Patel","year":"1993","journal-title":"Drugs"},{"key":"2024013114273409300_bib2","first-page":"177","article-title":"Paget's disease of bone","volume":"19","author":"Merkow","year":"1990","journal-title":"Endocrinol Metabol Clin N 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