{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,26]],"date-time":"2026-02-26T15:10:51Z","timestamp":1772118651702,"version":"3.50.1"},"reference-count":56,"publisher":"Oxford University Press (OUP)","issue":"9","license":[{"start":{"date-parts":[[2010,8,20]],"date-time":"2010-08-20T00:00:00Z","timestamp":1282262400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2010,9,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Chronic obstructive pulmonary disease (COPD) is associated with osteoporosis and fragility fractures. The objectives of this study were to assess static and dynamic indices of cancellous and cortical bone structure in postmenopausal women with COPD. Twenty women with COPD who had not received chronic oral glucocorticoids underwent bone biopsies after double tetracycline labeling. Biopsies were analyzed by histomorphometry and \u00b5CT and compared with age-matched controls. Distribution of the patients according to the Global Initiative for Chronic Obstructive Lung Disease (GOLD) was: Type I (15%), Type II (40%), Type III (30%), and Type IV (15%). Mean (\u00b1SD) cancellous bone volume (15.20\u2009\u00b1\u20095.91 versus 21.34\u2009\u00b1\u20095.53%, p\u2009=\u2009.01), trabecular number (1.31 \u2009\u00b1\u2009 0.26 versus 1.77\u2009\u00b1\u20090.51\/mm, p\u2009=\u2009.003), and trabecular thickness (141\u2009\u00b1\u200923 versus 174\u2009\u00b1\u200936 \u00b5m, p\u2009=\u2009.006) were lower in patients than in controls. Connectivity density was lower in COPD (5.56\u2009\u00b1\u20092.78 versus 7.94\u2009\u00b1\u20093.08\/mm, p\u2009=\u2009.04), and correlated negatively with smoking (r\u2009=\u2009\u22120.67; p\u2009=\u2009.0005). Trabecular separation (785\u2009\u00b1\u2009183 versus 614\u2009\u00b1\u2009136 \u00b5m, p\u2009=\u2009.01) and cortical porosity (4.11\u2009\u00b1\u20091.02 versus 2.32\u2009\u00b1\u20090.94 voids\/mm2; p\u2009&amp;lt;\u2009.0001) were higher in COPD while cortical width (458\u2009\u00b1\u2009214 versus 762\u2009\u00b1\u2009240 \u00b5m; p\u2009&amp;lt;\u2009.0001) was lower. Dynamic parameters showed significantly lower mineral apposition rate in COPD (0.56\u2009\u00b1\u20090.16 versus 0.66\u2009\u00b1\u20090.12 \u00b5m\/day; p\u2009=\u2009.01). Patients with more severe disease, GOLD III and IV, presented lower bone formation rate than GOLD I and II (0.028\u2009\u00b1\u20090.009 versus 0.016\u2009+\u20090.011 \u00b5m3\/\u00b5m2\/day; p\u2009=\u200904). This is the first evaluation of bone microstructure and remodeling in COPD. The skeletal abnormalities seen in cancellous and cortical bone provide an explanation for the high prevalence of vertebral fractures in this disease. \u00a9 2010 American Society for Bone and Mineral Research<\/jats:p>","DOI":"10.1002\/jbmr.88","type":"journal-article","created":{"date-parts":[[2010,6,20]],"date-time":"2010-06-20T21:07:18Z","timestamp":1277068038000},"page":"1931-1940","source":"Crossref","is-referenced-by-count":45,"title":["Skeletal microstructural abnormalities in postmenopausal women with chronic obstructive pulmonary disease"],"prefix":"10.1093","volume":"25","author":[{"given":"Carolina AM","family":"Kulak","sequence":"first","affiliation":[{"name":"Regional Bone Center, Helen Hayes Hospital, West Haverstraw, New York, USA"},{"name":"Department of Medicine and Pathology, Columbia University College of Physicians and Surgeons, New York, NY, USA"},{"name":"Endocrine Division (SEMPR), Department of Internal Medicine, Clinical Hospital of the Federal University of 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