{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,17]],"date-time":"2026-10-17T08:46:59Z","timestamp":1792226819065,"version":"4.4.0"},"reference-count":35,"publisher":"Oxford University Press (OUP)","issue":"9","license":[{"start":{"date-parts":[[2010,8,20]],"date-time":"2010-08-20T00:00:00Z","timestamp":1282262400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2010,9,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>With aging, the skeleton may lose its ability to respond to positive mechanical stimuli. We hypothesized that aged mice are less responsive to loading than young-adult mice. We subjected aged (22 months) and young-adult (7 months) BALB\/c male mice to daily bouts of axial tibial compression for 1 week and evaluated cortical and trabecular responses using micro\u2013computed tomography (\u00b5CT) and dynamic histomorphometry. The right legs of 95 mice were loaded for 60 rest-inserted cycles per day to 8, 10, or 12\u2009N peak force (generating mid-diaphyseal strains of 900 to 1900 \u00b5\u03b5 endocortically and 1400 to 3100 \u00b5\u03b5 periosteally). At the mid-diaphysis, mice from both age groups showed a strong anabolic response on the endocortex (Ec) and periosteum (Ps) [Ec.MS\/BS and Ps.MS\/BS: loaded (right) versus control (left), p\u2009&amp;lt;\u2009.05]. Generally, bone formation increased with increasing peak force. At the endocortical surface, contrary to our hypothesis, aged mice had a significantly greater response to loading than young-adult mice (Ec.MS\/BS and Ec.BFR\/BS: 22 months versus 7 months, p\u2009&amp;lt;\u2009.001). Responses at the periosteal surface did not differ between age groups (p\u2009&amp;gt;\u2009.05). The loading-induced increase in bone formation resulted in increased cortical area in both age groups (loaded versus control, p\u2009&amp;lt;\u2009.05). In contrast to the strong cortical response, loading only weakly stimulated trabecular bone formation. Serial (in vivo) \u00b5CT examinations at the proximal metaphysis revealed that loading caused a loss of trabecular bone in 7-month-old mice, whereas it appeared to prevent bone loss in 22-month-old mice. In summary, 1 week of daily tibial compression stimulated a robust endocortical and periosteal bone-formation response at the mid-diaphysis in both young-adult and aged male BALB\/c mice. We conclude that aging does not limit the short-term anabolic response of cortical bone to mechanical stimulation in our animal model. \u00a9 2010 American Society for Bone and Mineral Research<\/jats:p>","DOI":"10.1002\/jbmr.96","type":"journal-article","created":{"date-parts":[[2010,3,26]],"date-time":"2010-03-26T16:17:12Z","timestamp":1269620232000},"page":"2006-2015","source":"Crossref","is-referenced-by-count":88,"title":["Aged mice have enhanced endocortical response and normal periosteal response compared with young-adult mice following 1 week of axial tibial compression"],"prefix":"10.1093","volume":"25","author":[{"given":"Michael D","family":"Brodt","sequence":"first","affiliation":[{"name":"Department of Orthopaedic Surgery, Washington University, St. Louis, MO, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthew J","family":"Silva","sequence":"additional","affiliation":[{"name":"Department of Biomedical Engineering, Washington University, St. Louis, 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