{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T15:21:15Z","timestamp":1791040875060,"version":"4.1.0"},"reference-count":42,"publisher":"Oxford University Press (OUP)","issue":"9","license":[{"start":{"date-parts":[[2010,8,20]],"date-time":"2010-08-20T00:00:00Z","timestamp":1282262400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2010,9,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Patients with primary hyperparathyroidism (PHPT) have continuously elevated parathyroid hormone (PTH) and consequently increased bone turnover with negative effects on cortical (Ct) bone with preservation of trabecular (Tb) bone. High-resolution peripheral quantitative computed tomography (HR-pQCT) is a new technique for in vivo assessment of geometry, volumetric density, and microarchitecture at the radius and tibia. In this study we aimed to evaluate bone status in women with PHPT compared with controls using HR-pQCT. The distal radius and tibia of 54 women\u201427 patients with PHPT (median age 60, range 44\u201375 years) and 27 randomly recruited age-matched healthy controls (median age 60, range 44\u201376 years)\u2014were imaged using HR-pQCT along with areal bone mineral density (aBMD) by dual-energy X-ray absorptiomentry (DXA) of the ultradistal forearm, femoral neck, and spine (L1\u2013L4). Groups were comparable regarding age, height, and weight. In the radius, patients had reduced Ct area (Ct.Ar) (p\u2009=\u2009.008), Ct thickness (Ct.th) (p\u2009=\u2009.01) along with reduced total (p\u2009=\u2009.002), Ct (p\u2009=\u2009.02), and Tb (p\u2009=\u2009.02) volumetric density and reduced Tb number (Tb.N) (p\u2009=\u2009.04) and increased Tb spacing (Tb.sp) (p = .05). Ct porosity did not differ. In the tibia, no differences in HR-pQCT parameters were found. Moreover, patients had lower ultradistal forearm (p\u2009=\u2009.005), spine (p\u2009=\u2009.04), and femoral neck (p\u2009=\u20090.04) aBMD compared with controls. In conclusion, a negative bone effect of continuously elevated PTH with alteration of HR-pQCT assessed geometry, volumetric density, and both trabecular and cortical microarchitecture in radius but not tibia was found along with reduced aBMD by DXA at all sites in female patients with PHPT. \u00a9 2010 American Society for Bone and Mineral Research<\/jats:p>","DOI":"10.1002\/jbmr.98","type":"journal-article","created":{"date-parts":[[2010,4,1]],"date-time":"2010-04-01T19:48:54Z","timestamp":1270151334000},"page":"1941-1947","source":"Crossref","is-referenced-by-count":115,"title":["Effects on bone geometry, density, and microarchitecture in the distal radius but not the tibia in women with primary hyperparathyroidism: A case-control study using HR-pQCT"],"prefix":"10.1093","volume":"25","author":[{"given":"Stinus","family":"Hansen","sequence":"first","affiliation":[{"name":"Institute of Clinical Research, University of Southern Denmark, Odense, Denmark"},{"name":"Department of Endocrinology, Odense University Hospital, Odense, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jens-Erik","family":"Beck Jensen","sequence":"additional","affiliation":[{"name":"Osteoporosis Research Clinic, Hvidovre University Hospital, Hvidovre, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lars","family":"Rasmussen","sequence":"additional","affiliation":[{"name":"Department of Surgery, Odense University Hospital, Odense, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ellen M","family":"Hauge","sequence":"additional","affiliation":[{"name":"Department of Rheumatology, Aarhus University Hospital, Aarhus, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kim","family":"Brixen","sequence":"additional","affiliation":[{"name":"Institute of Clinical Research, University of Southern Denmark, Odense, Denmark"},{"name":"Department of Endocrinology, Odense University Hospital, Odense, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2010,8,20]]},"reference":[{"key":"2024020320110616900_bib1","doi-asserted-by":"crossref","first-page":"1317","DOI":"10.1016\/S0140-6736(80)91783-3","article-title":"Primary hyperparathyroidism: changes in the pattern of clinical presentation","volume":"1","author":"Mundy","year":"1980","journal-title":"Lancet."},{"key":"2024020320110616900_bib2","doi-asserted-by":"crossref","first-page":"755","DOI":"10.1016\/8756-3282(93)90207-Q","article-title":"Primary hyperparathyroidism: iliac crest cortical thickness, structure, and remodeling evaluated by histomorphometric methods","volume":"14","author":"Christiansen","year":"1993","journal-title":"Bone."},{"key":"2024020320110616900_bib3","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1016\/S0169-6009(08)80100-6","article-title":"Bone histomorphometry and serum concentrations of intact parathyroid hormone [PTH(1\u201384)] in patients with primary hyperparathyroidism","volume":"23","author":"van","year":"1993","journal-title":"Bone Miner."},{"key":"2024020320110616900_bib4","doi-asserted-by":"crossref","first-page":"930","DOI":"10.1210\/jcem-70-4-930","article-title":"The histomorphometry of bone in primary hyperparathyroidism: preservation of cancellous bone structure","volume":"70","author":"Parisien","year":"1990","journal-title":"J Clin Endocrinol Metab."},{"key":"2024020320110616900_bib5","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1016\/8756-3282(95)80020-Q","article-title":"Reconstruction of cortical bone remodeling in untreated primary hyperparathyroidism and following surgery","volume":"16","author":"Brockstedt","year":"1995","journal-title":"Bone."},{"key":"2024020320110616900_bib6","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1016\/j.bone.2007.03.020","article-title":"Preserved three-dimensional cancellous bone structure in mild primary hyperparathyroidism","volume":"41","author":"Dempster","year":"2007","journal-title":"Bone."},{"key":"2024020320110616900_bib7","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1007\/s007740050096","article-title":"Microstructure of the trabecula and cortex of iliac bone in primary hyperparathyroidism patients determined using histomorphometry and node-strut analysis","volume":"17","author":"Uchiyama","year":"1999","journal-title":"J Bone Miner Metab."},{"key":"2024020320110616900_bib8","doi-asserted-by":"crossref","first-page":"1393","DOI":"10.1002\/jbmr.5650100917","article-title":"Bone structure in postmenopausal hyperparathyroid, osteoporotic, and normal women","volume":"10","author":"Parisien","year":"1995","journal-title":"J Bone Miner Res."},{"key":"2024020320110616900_bib9","doi-asserted-by":"crossref","first-page":"268","DOI":"10.3109\/17453678909149275","article-title":"Increased fracture risk in hypercalcemia. 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