{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T17:41:08Z","timestamp":1789580468807,"version":"build-2803163510"},"reference-count":27,"publisher":"Oxford University Press (OUP)","issue":"9","license":[{"start":{"date-parts":[[2010,8,20]],"date-time":"2010-08-20T00:00:00Z","timestamp":1282262400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2010,9,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Children with calcium-deficiency rickets may have increased vitamin D requirements and respond differently to vitamin D2 and vitamin D3. Our objective was to compare the metabolism of vitamins D2 and D3 in rachitic and control children. We administered an oral single dose of vitamin D2 or D3 of 1.25\u2009mg to 49 Nigerian children\u201428 with active rickets and 21 healthy controls. The primary outcome measure was the incremental change in vitamin D metabolites. Baseline serum 25-hydroxyvitamin D [25(OH)D] concentrations ranged from 7 to 24 and 15 to 34\u2009ng\/mL in rachitic and control children, respectively (p\u2009&amp;lt;\u2009.001), whereas baseline 1,25-dihydroxyvitamin D [1,25(OH)2D] values (mean\u2009\u00b1\u2009SD) were 224\u2009\u00b1\u200972 and 121\u2009\u00b1\u200934\u2009pg\/mL, respectively (p\u2009&amp;lt;\u2009.001), and baseline 24,25-dihydroxyvitamin D [24,25(OH)2D] values were 1.13\u2009\u00b1\u20090.59 and 4.03\u2009\u00b1\u20091.33\u2009ng\/mL, respectively (p\u2009&amp;lt;\u2009.001). The peak increment in 25(OH)D was on day 3 and was similar with vitamins D2 and D3 in children with rickets (29\u2009\u00b1\u200917 and 25\u2009\u00b1\u200911\u2009ng\/mL, respectively) and in control children (33\u2009\u00b1\u200913 and 31\u2009\u00b1\u200916\u2009ng\/mL, respectively). 1,25(OH)2D rose significantly (p\u2009&amp;lt;\u2009.001) and similarly (p\u2009=\u2009.18) on day 3 by 166\u2009\u00b1\u200980 and 209\u2009\u00b1\u200983\u2009pg\/mL after vitamin D2 and D3 administration, respectively, in children with rickets. By contrast, control children had no significant increase in 1,25(OH)2D (19\u2009\u00b1\u200928 and 16\u2009\u00b1\u200938\u2009pg\/mL after vitamin D2 and D3 administration, respectively). We conclude that in the short term, vitamins D2 and D3 similarly increase serum 25(OH)D concentrations in rachitic and healthy children. A marked increase in 1,25(OH)2D in response to vitamin D distinguishes children with putative dietary calcium-deficiency rickets from healthy children, consistent with increased vitamin D requirements in children with calcium-deficiency rickets. \u00a9 2010 American Society for Bone and Mineral Research<\/jats:p>","DOI":"10.1002\/jbmr.99","type":"journal-article","created":{"date-parts":[[2010,4,1]],"date-time":"2010-04-01T19:30:57Z","timestamp":1270150257000},"page":"1988-1995","source":"Crossref","is-referenced-by-count":48,"title":["Comparison of metabolism of vitamins D2 and D3 in children with nutritional rickets"],"prefix":"10.1093","volume":"25","author":[{"given":"Tom D","family":"Thacher","sequence":"first","affiliation":[{"name":"Department of Family Medicine, Mayo Clinic, Rochester, MN, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philip R","family":"Fischer","sequence":"additional","affiliation":[{"name":"Department of Pediatric and Adolescent Medicine, Mayo Clinic, Rochester, MN, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael O","family":"Obadofin","sequence":"additional","affiliation":[{"name":"Department of Family Medicine, Jos University Teaching Hospital, Jos, Nigeria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael A","family":"Levine","sequence":"additional","affiliation":[{"name":"Division of Endocrinology and Diabetes, The Childrens Hospital of Philadelphia, and Department of Pediatrics, University of Pennsylvania School of Medicine, Philadelphia, PA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ravinder J","family":"Singh","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John M","family":"Pettifor","sequence":"additional","affiliation":[{"name":"MRC Mineral Metabolism Research Unit, Department of 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