{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,19]],"date-time":"2026-09-19T20:17:19Z","timestamp":1789849039141,"version":"4.0.1"},"reference-count":42,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2003,6,13]],"date-time":"2003-06-13T00:00:00Z","timestamp":1055462400000},"content-version":"vor","delay-in-days":12,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Biochem &amp; Molecular Tox"],"published-print":{"date-parts":[[2003,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>It has been recently postulated from our laboratory that Arabic gum (AG) offers a protective effect in the kidney of rats against nephrotoxicity induced by gentamicin via inhibiting lipid peroxidation. It has also recently shown a powerful antioxidant effect through scavenging superoxide anions. In this study we utilized a rat model of cisplatin (CP)\u2010induced nephrotoxicity to determine its peak time following (1, 2, 5, and 7 days) of a single CP (7.5 mg\/kg, i.p.) injection. Also, a possible protective effect of cotreatment with AG (7.5 g\/kg\/day p.o.) on CP\u2010induced nephrotoxicity was investigated. Biochemical as well as histological assessments were carried out. CP\u2010induced nephrotoxicity was manifested by significant elevations of the functional parameters blood urea, serum creatinine, and kidney\/body weight ratio. Maximum toxic effects of CP were observed 5 days after its injection, while it started after day 1 in the biochemical parameters, such as glutathione depletion in the kidney tissue with concomitant increases in lipid peroxides and platinum content. Additionally, severe necrosis and desquamation of tubular epithelial cells in renal cortex as well as interstitial nephritis were observed after 5 days in CP\u2010treated animals. Five days after AG cotreatment with CP did not protect the kidney from the damaging effects of CP. However, it significantly reduced CP\u2010induced lipid peroxidation. These findings suggest that lipid peroxidation is not the main cause of CP\u2010induced nephrotoxicity but it is rather more dependent on other factors such as platinum disposition in renal interstitial tubules. \u00a9 2003 Wiley Periodicals, Inc. J Biochem Mol Toxicol 17:146\u2013153, 2003; Published online in Wiley InterScience (www.interscience.wiley.com). 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