{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T09:32:04Z","timestamp":1791019924999,"version":"4.1.0"},"reference-count":14,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2007,8,22]],"date-time":"2007-08-22T00:00:00Z","timestamp":1187740800000},"content-version":"vor","delay-in-days":21,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Biochem &amp; Molecular Tox"],"published-print":{"date-parts":[[2007,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Nonalcoholic fatty liver disease encompasses a spectrum of hepatic pathologies ranging from simple fatty liver to an inflammatory state known as nonalcoholic steatohepatitis (NASH). NASH is also characterized by severe hepatic oxidative stress. The goal of this study was to determine whether genes of the antioxidant response are induced in rodent models of nonalcoholic fatty liver disease. To simulate simple fatty liver and NASH, respectively, male Sprague\u2010Dawley rats were fed a high\u2010fat (HF) or a methionine and choline\u2010deficient (MCD) diet for 8 weeks. Key marker genes of the antioxidant response that are known to undergo upregulation via activation of Nuclear Factor Erythroid 2\u2010Related Factor 2 were measured using the branched DNA signal amplification assay. Messenger RNA levels of the antioxidant response, including NAD(P)H:quinone oxidoreductase\u20101 (Nqo1), Glutamate cysteine ligase catalytic (Gclc), and Heme oxygenase\u20101 (Ho\u20101), were significantly induced in MCD rat liver but not in HF rat liver. Furthermore, Nqo1 protein expression and activity underwent significant upregulation in MCD rat liver but not in HF rat liver. These data strongly indicate that the pathology induced by the MCD dietary model of NASH results in upregulation of the antioxidant response in rats. \u00a9 2007 Wiley Periodicals, Inc. J Biochem Mol Toxicol 21:216\u2013220, 2007; Published online in Wiley InterScience (<jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"http:\/\/www.interscience.wiley.com\">www.interscience.wiley.com<\/jats:ext-link>). DOI 10.1002\/jbt.20177<\/jats:p>","DOI":"10.1002\/jbt.20177","type":"journal-article","created":{"date-parts":[[2007,8,23]],"date-time":"2007-08-23T08:25:43Z","timestamp":1187857543000},"page":"216-220","source":"Crossref","is-referenced-by-count":35,"title":["Genes of the antioxidant response undergo upregulation in a rodent model of nonalcoholic steatohepatitis"],"prefix":"10.1002","volume":"21","author":[{"given":"Andrew J.","family":"Lickteig","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Craig D.","family":"Fisher","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lisa M.","family":"Augustine","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nathan J.","family":"Cherrington","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2007,8,22]]},"reference":[{"key":"e_1_2_1_2_2","first-page":"S17","article-title":"Pathophysiology of nonalcoholic steatohepatitis","volume":"40","author":"McCullough AJ.","year":"2006","journal-title":"J Clin Gastroenterol"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.1186\/1471-230X-5-35"},{"key":"e_1_2_1_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2004.11.040"},{"key":"e_1_2_1_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0168-8278(03)00376-3"},{"key":"e_1_2_1_6_2","doi-asserted-by":"publisher","DOI":"10.1093\/toxsci\/kfh128"},{"key":"e_1_2_1_7_2","doi-asserted-by":"publisher","DOI":"10.1124\/dmd.105.007542"},{"key":"e_1_2_1_8_2","doi-asserted-by":"publisher","DOI":"10.1379\/CSC-217.1"},{"key":"e_1_2_1_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.freeradbiomed.2004.04.033"},{"key":"e_1_2_1_10_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.185.4151.573"},{"key":"e_1_2_1_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0891-5849(02)00788-8"},{"key":"e_1_2_1_12_2","doi-asserted-by":"publisher","DOI":"10.1002\/hep.510270327"},{"key":"e_1_2_1_13_2","doi-asserted-by":"publisher","DOI":"10.1002\/9780470123119.ch3"},{"key":"e_1_2_1_14_2","doi-asserted-by":"publisher","DOI":"10.1128\/MCB.25.14.5933-5946.2005"},{"issue":"6","key":"e_1_2_1_15_2","first-page":"813","article-title":"Human and rat liver phenol sulfotransferase: Structure\u2010activity relationships for phenolic substrates","volume":"32","author":"Campbell NRC","year":"1987","journal-title":"Mol Pharm"}],"container-title":["Journal of Biochemical and Molecular Toxicology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fjbt.20177","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jbt.20177","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,12]],"date-time":"2023-09-12T22:07:52Z","timestamp":1694556472000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/jbt.20177"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007,8]]},"references-count":14,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2007,8]]}},"alternative-id":["10.1002\/jbt.20177"],"URL":"https:\/\/doi.org\/10.1002\/jbt.20177","archive":["Portico"],"relation":{},"ISSN":["1095-6670","1099-0461"],"issn-type":[{"value":"1095-6670","type":"print"},{"value":"1099-0461","type":"electronic"}],"subject":[],"published":{"date-parts":[[2007,8]]}}}