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Male Wistar albino rats (180\u2013220 g) were allocated into a normal control group, ulcer control group (received a single dose of indomethacin 40 mg\u2013kg p.o.), and two ulcer groups pretreated with spermine (150 mg\u2013kg p.o. 1 h before ulcer induction) and taurine (250 mg\u2013kg i.p. for three consecutive days before ulcer induction). The animals were killed 6 h after indomethacin administration, and the gastric juice, serum, and mucosal tissue were used for gastric injury evaluation. Both modulators significantly ameliorated the indomethacin\u2013induced gastric lesions in glandular mucosa. Notably, spermine exhibited the most pronounced effect as manifested by great reduction in the gastric ulcer index, normalization of the elevated gastric acidity, and triggering of mucin production. Spermine and taurine were able to decrease the elevated levels of gastric myeloperoxidase, conjugated diene, and serum NO. However, the lowered tissue NO content was markedly elevated only by taurine. The antioxidant action of taurine was illustrated by restoration of the depressed content of glutathione, normalization of the inhibited activities of glutathione reductase, and superoxide dismutase. These results suggest that spermine and taurine confer significant gastroprotection against indomethacin\u2010induced gastric injury with the priority of spermine. \u00a9 2007 Wiley Periodicals, Inc. J Biochem Mol Toxicol 21:280\u2013288, 2007; Published online in Wiley InterScience (<jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"http:\/\/www.interscience.wiley.com\">www.interscience.wiley.com<\/jats:ext-link>). 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