{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,12]],"date-time":"2025-11-12T06:13:23Z","timestamp":1762928003014},"reference-count":58,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2008,10,28]],"date-time":"2008-10-28T00:00:00Z","timestamp":1225152000000},"content-version":"vor","delay-in-days":57,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Biochem &amp; Molecular Tox"],"published-print":{"date-parts":[[2008,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Mercury is a heavy metal that can cause a variety of toxic effects on the organism, such as hematological and immunological alterations. In the present investigation, deleterious effects of mercury\u2010intoxication in mice and a possible protective effect of diphenyl diselenide (PhSe)<jats:sub>2<\/jats:sub> were studied. Male adult Swiss albino mice received daily a pretreatment with (PhSe)<jats:sub>2<\/jats:sub> (15.6 mg\/kg, orally) for 1 week. After this week, mice received daily mercuric chloride (1 mg\/kg, subcutaneously) for 2 weeks. A number of hematological (erythrocytes, leukocytes, platelets, hemoglobin, hematocrit, reticulocytes, and leukocytes differential) and immunological (immunoglobulin G and M plasma concentration) parameters were evaluated. Another biomarker of tissue damage, lactate dehydrogenase (LDH), was also determined. The results demonstrated that mercury exposure caused a reduction in the erythrocyte, hematocrit, hemoglobin, leukocyte, and platelet counts and an increase in the reticulocyte percentages. (PhSe)<jats:sub>2<\/jats:sub> was effective in protecting against the reduction in hematocrit, hemoglobin, and leukocyte levels. (PhSe)<jats:sub>2<\/jats:sub> ameliorated reticulocyte percentages increased by mercury. However, (PhSe)<jats:sub>2<\/jats:sub> was partially effective in preventing against the decrease in erythrocyte and platelet counts. Immunoglobulin G and M concentrations and LDH activity were increased by mercury exposure, and (PhSe)<jats:sub>2<\/jats:sub> was effective in protecting against these effects. In conclusion, (PhSe)<jats:sub>2<\/jats:sub> was effective in protecting against hematological and immunological alterations induced by mercury in mice. \u00a9 2008 Wiley Periodicals, Inc. J Biochem Mol Toxicol 22:311\u2013319, 2008; Published online in Wiley InterScience (<jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"http:\/\/www.interscience.wiley.com\">www.interscience.wiley.com<\/jats:ext-link>). 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