{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T14:46:43Z","timestamp":1786978003426,"version":"build-2736575974"},"reference-count":50,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2008,10,28]],"date-time":"2008-10-28T00:00:00Z","timestamp":1225152000000},"content-version":"vor","delay-in-days":57,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Biochem &amp; Molecular Tox"],"published-print":{"date-parts":[[2008,9]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Adult virgin 4\u2010day cycling synchronized Charles foster females were treated subcutaneously (0.05 mg\/kg body wt\/day) with sodium acetate (control), lead acetate or cadmium acetate alone, or both during gestational period, with pretreatment of 5 days prior to mating. There were no alterations in reproductive performance in all metal\u2010treated groups. Implantation enzymes, cathepsin\u2010D and alkaline phosphatase, activity were altered, but no change in the reproductive performance was observed. The key steroidogenic enzymes of ovary and placenta (3\u03b2\u2010HSD and 17\u03b2\u2010HSD), along with gonadal steroids, were affected the most in cadmium and combined treated animals whereas lead\u2010treated animals showed a minimum change compared to the control group. Maximum displacement of zinc bound to metallothionein was more in cadmium and combined treated rats when compared to other metal\u2010treated groups. Biomolecules such as glycogen, protein, RNA, DNA, and protein content were affected in all metal\u2010treated groups, whereas cadmium\u2010treated animals showed greater effect. General parameters of toxicity such as alkaline phosphatase, serum glutamate pyruvate transaminase, and creatinine were altered but were within the normal range. Biochemical effects are correlated with metals accumulated in blood, reproductive tissue such as placenta and ovary. \u00a9 2008 Wiley Periodicals, Inc. J Biochem Mol Toxicol 22:337\u2013344, 2008; Published online in Wiley InterScience (\n                    <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"http:\/\/www.interscience.wiley.com\">www.interscience.wiley.com<\/jats:ext-link>\n                    ). 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