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Wistar rats were inoculated intraperitoneally with saline (control) or <jats:italic>Cdt<\/jats:italic> venom. After 3, 4, or 6 h, the following parameters were analyzed: (a) hepatic function, (b) oxidative stress parameters, and (c) the metabolism of alanine in the isolated perfused liver. Plasma activities of alanine aminotransferase and aspartate aminotransferase and hepatic glutathione S\u2010transferase and catalase presented significant elevation in rats inoculated with 300 \u03bcg \u22c5 kg<jats:sup>\u22121<\/jats:sup> <jats:italic>Cdt<\/jats:italic> venom. Liver lipoperoxidation was enormously increased by venom doses of 100, 200, and 300 \u03bcg \u22c5kg<jats:sup>\u22121<\/jats:sup>, whereas glutathione S\u2010transferase was not changed. Perfused livers from rats inoculated with 1500 \u03bcg \u22c5kg<jats:sup>\u22121<\/jats:sup> venom showed increased production of lactate, pyruvate, and ammonia when alanine was the metabolic substrate. These results demonstrate that the <jats:italic>Cdt<\/jats:italic> venom can produce several changes in hepatocytes. The causes of the changes are possibly related to the disequilibrium in the redox homeostasis but also to specific needs of the poisoned organism, for example, an increased supply of lactate and pyruvate in response to an increased activity of the Cori cycle. \u00a9 2010 Wiley Periodicals, Inc. J Biochem Mol Toxicol 25:195\u2013203, 2011; View this article online at <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"wileyonlinelibrary.com\">wileyonlinelibrary.com<\/jats:ext-link>. DOI 10.1002\/jbt.20376<\/jats:p>","DOI":"10.1002\/jbt.20376","type":"journal-article","created":{"date-parts":[[2010,11,16]],"date-time":"2010-11-16T04:40:26Z","timestamp":1289882426000},"page":"195-203","source":"Crossref","is-referenced-by-count":23,"title":["Effects of the <i>crotalus durissus terrificus<\/i> snake venom on hepatic metabolism and oxidative stress"],"prefix":"10.1002","volume":"25","author":[{"given":"Jonas Golart da","family":"Silva","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bruna da Silva","family":"Soley","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vanessa","family":"Gris","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amanda do Rocio Andrade","family":"Pires","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Silvia Maria Suter Correia","family":"Caderia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gabrielle Jackin","family":"Eler","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aparecida Pinto Munhos","family":"Hermoso","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adelar","family":"Bracht","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paulo Roberto","family":"Dalsenter","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexandra","family":"Acco","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2010,11,15]]},"reference":[{"key":"e_1_2_6_2_2","unstructured":"FUNASA.Minist\u00e9rio da Sa\u00fade Brasil. 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