{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,4]],"date-time":"2025-10-04T22:15:34Z","timestamp":1759616134825},"reference-count":40,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2011,9,6]],"date-time":"2011-09-06T00:00:00Z","timestamp":1315267200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Biochem &amp; Molecular Tox"],"published-print":{"date-parts":[[2012,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The objective of this study was to determine the effect of fluoride (F) and arsenic (As) on the activity of acetylcholinesterase (AChE), a critically important nervous system enzyme, and to test the protective role of buffalo epiphyseal (pineal) proteins (BEP) in rats. Arsenic (20 mg\/kg BW, intraperitoneally) and F (150 ppm, perorally) were exposed, and BEP was administered intraperitoneally (100 \u03bc <jats:italic>g<\/jats:italic>\/kg BW) along with F and As to rats for 7 days. As and F exposure significantly (<jats:italic>p<\/jats:italic> &lt; 0.05) increased their levels in plasma and decreased the activity of AChE in plasma, RBCs, heart, and brain of rats. Interestingly, As\u2010 and F\u2010induced inhibition of AChE activities increased As and F levels in plasma, and organs were significantly (<jats:italic>p<\/jats:italic> &lt; 0.05) counteracted by BEP administration. These findings indicate the protective role of buffalo (<jats:italic>Bubalus bubalis<\/jats:italic>) epiphyseal proteins on F\u2010 and As\u2010induced adverse changes in AChE activity as a candidate biomarker for neurotoxicity in female rats. \u00a9 2011 Wiley Periodicals, Inc. J Biochem Mol Toxicol 26:10\u201315 2012; View this article online at <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"wileyonlinelibrary.com\">wileyonlinelibrary.com<\/jats:ext-link>. DOI 10.1002\/jbt.20407<\/jats:p>","DOI":"10.1002\/jbt.20407","type":"journal-article","created":{"date-parts":[[2011,9,6]],"date-time":"2011-09-06T18:38:52Z","timestamp":1315334332000},"page":"10-15","source":"Crossref","is-referenced-by-count":12,"title":["Buffalo (<i>Bubalus bubalis<\/i>) epiphyseal proteins give protection from arsenic and fluoride\u2010induced adverse changes in acetylcholinesterase activity in rats"],"prefix":"10.1002","volume":"26","author":[{"given":"Vijay K.","family":"Bharti","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R. 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