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We investigated, by quantitative polymerase chain reaction, whether the expression of liver <jats:italic>hepcidin, ferritin<\/jats:italic>, and <jats:italic>TfR\u20101<\/jats:italic> is altered in diabetes. Rats in the control (C) group received a standard diet; control iron (CI) group received a standard diet supplemented with iron; diabetic (D) group received an injection of streptozotocin; and diabetic iron (DI) group received streptozotocin and the diet with iron. Animals of the D group showed higher levels of serum iron, increased concentration of carbonyl protein, and a decrease in antioxidant status. Group D rats showed increased hepatic expression of <jats:italic>Trf\u20101<\/jats:italic> compared to the other groups. Iron supplementation reversed this increase. <jats:italic>Hepcidin<\/jats:italic> mRNA was 81% higher in DI than in C and CI rats. The results suggest that diabetes, with or without excess iron, can cause perturbations in iron status, hepcidin and Trf\u20101 expression. \u00a9 2012 Wiley Periodicals, Inc. J Biochem Mol Toxicol 26:123\u2013129, 2012; View this article online at <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"wileyonlinelibrary.com\">wileyonlinelibrary.com<\/jats:ext-link>. 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