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Curcumin (200 mg\/kg b.w), GTE (150 mg\/kg b.w), and NAC (490 mg\/kg b.w) were administered orally for 14 days with concomitant administration of cyclophosphamide (CP). Lung fibrosis was assessed by measuring hydroxyproline and elastin levels and confirmed by histopathological examination. Oxidative stress was also observed in the CP group. Lung myeloperoxidase activity was significantly decreased in animals of the CP group. <jats:italic>N<\/jats:italic>\u2010acetyl\u2010\u03b2\u2010<jats:sc>d<\/jats:sc>\u2010glucosaminidase, leukotriene C<jats:sub>4<\/jats:sub>, and protein were increased in bronchoalveolar lavage fluid (BALF). Transforming growth factor\u2010\u03b2, interleukin \u20101\u03b2, and histamine were increased in both serum and BALF. All modulators markedly attenuated the altered biochemical parameters as compared to CP\u2010treated rats. These results suggest the possibility of using these treatments as protective agents with chemotherapy and as protective agents for lung fibrosis. \u00a9 2012 Wiley Periodicals, Inc. J Biochem Mol Toxicol 26:461\u2010468, 2012; View this article online at <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"http:\/\/www.wileyonlinelibrary.com\">wileyonlinelibrary.com<\/jats:ext-link>. 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