{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,20]],"date-time":"2026-06-20T01:53:17Z","timestamp":1781920397134,"version":"3.54.5"},"reference-count":36,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2013,6,25]],"date-time":"2013-06-25T00:00:00Z","timestamp":1372118400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Biochem &amp; Molecular Tox"],"published-print":{"date-parts":[[2013,8]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:p>Sulfur dioxide (SO<jats:sub>2<\/jats:sub>) is naturally synthesized by glutamate\u2010oxaloacetate transaminase (GOT) from <jats:sc>l<\/jats:sc>\u2010cysteine in mammalian cells. We aim to investigate the role of SO<jats:sub>2<\/jats:sub> in inflammation in acute lung injury (ALI) following limb ischemia\/reperfusion (I\/R). Male Wistar rats were subjected to limb I\/R and were injected with saline, GOT inhibitor hydroxamate (HDX, 0.47 mmol\/kg), or the SO<jats:sub>2<\/jats:sub> donor Na<jats:sub>2<\/jats:sub>SO<jats:sub>3<\/jats:sub>\/NaHSO<jats:sub>3<\/jats:sub> (0.54 mmol\/kg\/0.18 mmol\/kg). Compared with the sham operation, the plasma SO<jats:sub>2<\/jats:sub> levels were significantly decreased by limb I\/R treatment. In addition, SO<jats:sub>2<\/jats:sub> concentration and GOT activity in the lung tissue were also reduced in ALI. The occurrence of ALI following limb I\/R can be prevented by Na<jats:sub>2<\/jats:sub>SO<jats:sub>3<\/jats:sub>\/NaHSO<jats:sub>3<\/jats:sub> treatment, whereas it can be significantly aggravated by HDX. The plasma IL\u20101\u03b2, IL\u20106, and IL\u201010 levels were consistent with myeloperoxidase activity and inflammation in lung tissue. In conclusion, our data suggest that downregulation of endogenous SO<jats:sub>2<\/jats:sub> production might be involved in pathogenesis of ALI following limb I\/R in rats. \u00a9 2013 Wiley Periodicals, Inc. J BiochemMol Toxicol 27:389\u2010397, 2013; View this article online at <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"http:\/\/www.wileyonlinelibrary.com\">wileyonlinelibrary.com<\/jats:ext-link>. 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