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Current investigation was undertaken to evaluate the role of carnosine, metformin, and<jats:italic>N<\/jats:italic>\u2010acetyl cysteine as putative glyoxal (carbonyl) traps, against methimazole\u2010induced hepatotoxicity. Methimazole (100 mg\/kg, intraperitoneally) was administered to intact and\/or glutathione (GSH)\u2011depleted mice and the role of glyoxal trapping agents was investigated. Methimazole caused liver injury as revealed by an increase in serum alanine aminotransferase and aspartate aminotransferase. Moreover, lipid peroxidation and protein carbonylation occurred significantly in methimazole\u2011treated animals\u2019 liver. Hepatic GSH reservoirs were decreased, and inflammatory cells infiltration was observed in liver histopathology. Methimazole\u2011induced hepatotoxicity was severe in GSH\u2010depleted mice and accompanied with interstitial hemorrhage and necrosis of the liver. Glyoxal trapping agents effectively diminished methimazole\u2010induced liver injury both in intact and\/or GSH\u2011depleted animals.<\/jats:p>","DOI":"10.1002\/jbt.21682","type":"journal-article","created":{"date-parts":[[2014,12,24]],"date-time":"2014-12-24T13:53:30Z","timestamp":1419429210000},"page":"173-181","source":"Crossref","is-referenced-by-count":34,"title":["Carbonyl Traps as Potential Protective Agents against Methimazole\u2011Induced Liver Injury"],"prefix":"10.1002","volume":"29","author":[{"given":"Reza","family":"Heidari","sequence":"first","affiliation":[{"name":"Pharmaceutical Sciences Research Center Shiraz University of Medical Sciences Shiraz Iran"},{"name":"Gerash School of Paramedical Sciences Shiraz University of Medical Sciences Gerash Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hossein","family":"Niknahad","sequence":"additional","affiliation":[{"name":"Pharmaceutical Sciences Research Center Shiraz University of Medical Sciences Shiraz Iran"},{"name":"Department of Pharmacology and Toxicology Shiraz University of Medical Sciences Shiraz Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Akram","family":"Jamshidzadeh","sequence":"additional","affiliation":[{"name":"Pharmaceutical Sciences Research Center Shiraz University of Medical Sciences Shiraz Iran"},{"name":"Department of Pharmacology and Toxicology Shiraz University of Medical Sciences Shiraz Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Negar","family":"Azarpira","sequence":"additional","affiliation":[{"name":"Transplant Research Center Shiraz University of Medical Sciences Shiraz Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mandana","family":"Bazyari","sequence":"additional","affiliation":[{"name":"Department of Pharmacology and Toxicology Shiraz University of Medical Sciences International Branch (Kish) Shiraz Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Asma","family":"Najibi","sequence":"additional","affiliation":[{"name":"Pharmaceutical Sciences Research Center Shiraz University of Medical Sciences Shiraz Iran"},{"name":"Department of Pharmacology and Toxicology Shiraz University of Medical Sciences Shiraz Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2014,12,24]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2009-2752"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.2174\/157488609789006912"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.4158\/EP.8.3.222"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1099-1263(199905\/06)19:3<193::AID-JAT553>3.0.CO;2-9"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1021\/tx990155o"},{"issue":"2","key":"e_1_2_6_7_1","first-page":"97","article-title":"Amodiaquine\u2010induced toxicity in isolated rat hepatocytes and the cytoprotective effects of taurine and\/or N\u2010acetyl cysteine","volume":"9","author":"Heidari R","year":"2014","journal-title":"Res Pharm Sci"},{"issue":"5","key":"e_1_2_6_8_1","doi-asserted-by":"crossref","first-page":"591","DOI":"10.1016\/S0090-9556(25)06329-9","article-title":"Metabolism of methimazole by rat liver cytochrome P\u2010450\u2010containing monoxygenases","volume":"6","author":"Lee PW","year":"1978","journal-title":"Drug Metab Dispos"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1124\/dmd.110.037895"},{"issue":"1","key":"e_1_2_6_10_1","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1016\/S0090-9556(25)07818-3","article-title":"Loss of rat liver microsomal cytochrome P\u2010450 during methimazole metabolism. 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