{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,19]],"date-time":"2026-02-19T02:02:17Z","timestamp":1771466537147,"version":"3.50.1"},"reference-count":13,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2015,1,5]],"date-time":"2015-01-05T00:00:00Z","timestamp":1420416000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Biochem &amp; Molecular Tox"],"published-print":{"date-parts":[[2015,4]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:p>The present study aims to evaluate the antihyperlipidaemic, antihypertrophic, and reducing effects of zingerone on isoproterenol\u2010induced hyperlipidaemia and hypertrophy in rats. Rats were pretreated with zingerone (6 mg\/kg body weight) daily for a period of 14 days and then induced myocardial infarction with isoproterenol (100 mg\/kg body weight) on days 15 and 16. Isoproterenol increased serum creatine kinase and lactate dehydrogenase activities in the rats. Increased levels\/concentrations of serum and heart cholesterol and triglycerides were observed in isoproterenol\u2010induced myocardial infarcted rats. Isoproterenol also altered serum lipoproteins and the activity of liver 3\u2010hydroxy\u20103\u2010methyl glutaryl\u2010coenzyme\u2010A\u2010reductase in the rats. The in vitro study revealed a very convincing reducing power of zingerone. Pretreatment with zingerone prevented hyperlipidaemia and cardiac hypertrophy, by virtue of its antihyperlipidaemic, antihypertrophic, and reducing properties in isoproterenol\u2010induced myocardial infarcted rats.<\/jats:p>","DOI":"10.1002\/jbt.21683","type":"journal-article","created":{"date-parts":[[2015,1,5]],"date-time":"2015-01-05T07:53:26Z","timestamp":1420444406000},"page":"182-188","source":"Crossref","is-referenced-by-count":28,"title":["Antihyperlipidaemic, Antihypertrophic, and Reducing Effects of Zingerone on Experimentally Induced Myocardial Infarcted Rats"],"prefix":"10.1002","volume":"29","author":[{"given":"K. L.","family":"Hemalatha","sequence":"first","affiliation":[{"name":"Department of Biochemistry and Biotechnology Annamalai University  Tamil Nadu 608 002 India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P.","family":"Stanely Mainzen Prince","sequence":"additional","affiliation":[{"name":"Department of Biochemistry and Biotechnology Annamalai University  Tamil Nadu 608 002 India"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2015,1,5]]},"reference":[{"key":"e_1_2_5_2_1","first-page":"290","article-title":"A simple and fast experimental model of myocardial infarction in the mouse","volume":"33","author":"Wang J","year":"2006","journal-title":"Tex Heart Inst J"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejphar.2011.09.036"},{"key":"e_1_2_5_4_1","first-page":"324","article-title":"Role of cyclooxygenase\u20102 in myocardial infarction and ischemia","volume":"16","author":"Saeed SA","year":"2006","journal-title":"J Coll Physicians Surg Pak"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/JBT.21668"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1093\/cvr\/27.3.442"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9258(18)64849-5"},{"key":"e_1_2_5_8_1","first-page":"486","article-title":"A new method for the direct determination of serum cholesterol","volume":"41","author":"Zlatkis A","year":"1953","journal-title":"J Lab Clin Med"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.1093\/clinchem\/28.10.2077"},{"issue":"975","key":"e_1_2_5_10_1","first-page":"1523","article-title":"Indirect assessment of hydroxy methyl glutaryl\u2010CoA reductase (NADPH) activity in liver tissue","volume":"21","author":"Rao AV","journal-title":"Clin Chem"},{"key":"e_1_2_5_11_1","doi-asserted-by":"publisher","DOI":"10.5264\/eiyogakuzashi.44.307"},{"key":"e_1_2_5_12_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.RES.48.1.1"},{"key":"e_1_2_5_13_1","first-page":"575","article-title":"Isoproterenol induced myocardial infarction in rats: functional and biochemical alterations","volume":"22","author":"Nirmala C","year":"1994","journal-title":"Med Sci Res"},{"key":"e_1_2_5_14_1","unstructured":"HuangXT WangNS.Pharmacokinetic studies of zingerone in rats. 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Guangzhou University of Traditional Chinese Medicine."}],"container-title":["Journal of Biochemical and Molecular Toxicology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fjbt.21683","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jbt.21683","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,3]],"date-time":"2023-10-03T16:07:54Z","timestamp":1696349274000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/jbt.21683"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,1,5]]},"references-count":13,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2015,4]]}},"alternative-id":["10.1002\/jbt.21683"],"URL":"https:\/\/doi.org\/10.1002\/jbt.21683","archive":["Portico"],"relation":{},"ISSN":["1095-6670","1099-0461"],"issn-type":[{"value":"1095-6670","type":"print"},{"value":"1099-0461","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,1,5]]}}}