{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,4]],"date-time":"2026-06-04T16:22:40Z","timestamp":1780590160207,"version":"3.54.1"},"reference-count":25,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2015,10,13]],"date-time":"2015-10-13T00:00:00Z","timestamp":1444694400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Biochem &amp; Molecular Tox"],"published-print":{"date-parts":[[2016,3]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:p>This study evaluates the protective effects of 7\u2010hydroxycoumarin (7\u2010HC) on dyslipidemia and cardiac hypertrophy in isoproterenol (ISO) induced myocardial infarction (MI) in rats. Rats were pre\u2010 and co treated with 7\u2010HC (16 mg\/kg) daily for 8 days. ISO (100 mg\/kg) was subcutaneously injected into rats on seventh and eighth days to induce MI. Increased activity\/levels of serum creatine kinase\u2010MB (CK\u2010MB), troponin\u2010T, plasma lipid peroxidation products, and altered levels of lipids in the serum and heart and serum lipoproteins were noted in ISO\u2010induced rats. ISO\u2010induced myocardial infarcted rats revealed increased hypertrophy (cardiac and left ventricular) and hepatic 3\u2010hydroxyl 3\u2010methylglutaryl\u2010coenzyme\u2010A reductase (HMG\u2010CoA reductase) activity. Pre and cotreatment with 7\u2010HC revealed significant protective effects on all the biochemical parameters evaluated. The in vitro study demonstrated its free radical scavenging property. Thus, 7\u2010HC protects ISO\u2010induced MI in rats by its free radical scavenging and antihyperlipidaemic and antihypertrophic properties.<\/jats:p>","DOI":"10.1002\/jbt.21770","type":"journal-article","created":{"date-parts":[[2015,10,13]],"date-time":"2015-10-13T16:04:35Z","timestamp":1444752275000},"page":"120-127","source":"Crossref","is-referenced-by-count":32,"title":["Protective Effects of 7\u2010Hydroxycoumarin on Dyslipidemia and Cardiac Hypertrophy in Isoproterenol\u2010Induced Myocardial Infarction in Rats"],"prefix":"10.1002","volume":"30","author":[{"given":"Govindan Sangaran","family":"Jagadeesh","sequence":"first","affiliation":[{"name":"Department of Biochemistry and Biotechnology Annamalai University  Annamalai Nagar\u2010 608 002 India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M. F.","family":"Nagoor Meeran","sequence":"additional","affiliation":[{"name":"Department of Biochemistry and Biotechnology Annamalai University  Annamalai Nagar\u2010 608 002 India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Palanisamy","family":"Selvaraj","sequence":"additional","affiliation":[{"name":"Department of Biochemistry and Biotechnology Annamalai University  Annamalai Nagar\u2010 608 002 India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2015,10,13]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1745-7254.2006.00319.x"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.metabol.2012.06.003"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/jbt.20151"},{"key":"e_1_2_6_5_1","first-page":"78","article-title":"Comparative effects of Aegle marmelos extract and alpha\u2010tocopherol on serum lipids, lipid peroxides and cardiac enzyme levels in rats with isoproterenol\u2010induced myocardial infarction","volume":"46","author":"Rajadurai M","year":"2005","journal-title":"Singapore Med J"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0008-6363(97)00212-5"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jff.2015.01.013"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.foodres.2011.10.009"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejphar.2009.03.027"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.toxicon.2011.02.024"},{"key":"e_1_2_6_11_1","first-page":"1442","article-title":"Dose dependent pharmacokinetics of coumarin, 7\u2010hydroxycoumarin and 7\u2010hydroxycoumarin glucuronide upon intraperitoneal administration of coumarin and 7\u2010hydroxycoumarin in the rat","volume":"33","author":"Hardt TJ","year":"1983","journal-title":"Arzneimittelforschung"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/jbt.21419"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/0009-3084(87)90071-5"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/0003-2697(92)90122-N"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/0014-4800(68)90041-5"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-2952(02)01625-8"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9258(18)64849-5"},{"key":"e_1_2_6_18_1","first-page":"486","article-title":"A new method for the direct determination of serum cholesterol","volume":"41","author":"Zlatkis A","year":"1953","journal-title":"J Lab Clin Med"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1093\/clinchem\/28.10.2077"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/0009-8981(73)90016-8"},{"key":"e_1_2_6_21_1","first-page":"155","article-title":"Microdetermination of plasma phospholipids by trichloroacetic acid precipitation","volume":"35","author":"Zilversmit DB","year":"1950","journal-title":"J Lab Clin Med"},{"key":"e_1_2_6_22_1","doi-asserted-by":"crossref","first-page":"1523","DOI":"10.1093\/clinchem\/21.10.1523","article-title":"Indirect assessment of hydroxymethylglutaryl\u2010CoA reductase (NADPH) activity in liver tissue","volume":"21","author":"Rao AV","year":"1975","journal-title":"Clin Chem"},{"key":"e_1_2_6_23_1","doi-asserted-by":"publisher","DOI":"10.1002\/ptr.687"},{"key":"e_1_2_6_24_1","doi-asserted-by":"publisher","DOI":"10.1002\/jbt.21431"},{"key":"e_1_2_6_25_1","first-page":"134","article-title":"Effect of carnitine on malondialdehyde, taurine and glutathione levels in heart of rats subjected to myocardial stress by isoproterenol","volume":"27","author":"Kumari SS","year":"1989","journal-title":"Indian J Exp Biol"},{"key":"e_1_2_6_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejphar.2011.11.043"}],"container-title":["Journal of Biochemical and Molecular Toxicology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fjbt.21770","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jbt.21770","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,4]],"date-time":"2023-10-04T02:25:37Z","timestamp":1696386337000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/jbt.21770"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,10,13]]},"references-count":25,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2016,3]]}},"alternative-id":["10.1002\/jbt.21770"],"URL":"https:\/\/doi.org\/10.1002\/jbt.21770","archive":["Portico"],"relation":{},"ISSN":["1095-6670","1099-0461"],"issn-type":[{"value":"1095-6670","type":"print"},{"value":"1099-0461","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,10,13]]}}}