{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T01:03:52Z","timestamp":1792717432281,"version":"4.5.0"},"reference-count":74,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2015,11,5]],"date-time":"2015-11-05T00:00:00Z","timestamp":1446681600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Biochem &amp; Molecular Tox"],"published-print":{"date-parts":[[2016,4]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:p>Antibiotics are widely used in zoo technical and veterinary practices as feed supplementation to ensure wellness of farmed animals and livestock. Several evidences have been suggesting both the toxic role for tetracyclines, particularly for oxytetracycline (OTC). This potential toxicity appears of great relevance for human nutrition and for domestic animals. This study aimed to extend the evaluation of such toxicity. The biologic impact of the drug was assessed by evaluating the proinflammatory effect of OTC and their bone residues on cytokine secretion by in vitro human peripheral blood lymphocytes. Our results showed that both OTC and OTC\u2010bone residues significantly induced the T lymphocyte and non\u2010T cell secretion of interferon (IFN)\u2010\u03b3, as cytokine involved in inflammatory responses in humans as well as in animals. These results may suggest a possible implication for new potential human and animal health risks depending on the entry of tetracyclines in the food\u2010processing chain.<\/jats:p>","DOI":"10.1002\/jbt.21775","type":"journal-article","created":{"date-parts":[[2015,11,5]],"date-time":"2015-11-05T08:03:38Z","timestamp":1446710618000},"page":"170-177","source":"Crossref","is-referenced-by-count":37,"title":["Toxicological Implications and Inflammatory Response in Human Lymphocytes Challenged with Oxytetracycline"],"prefix":"10.1002","volume":"30","author":[{"given":"A.","family":"Di Cerbo","sequence":"first","affiliation":[{"name":"School of Specialization in Clinical Biochemistry \u201cG. d'Annunzio\u201d University Chieti Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A. T.","family":"Palatucci","sequence":"additional","affiliation":[{"name":"PhD School of Science University of Basilicata 85100 Potenza Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"V.","family":"Rubino","sequence":"additional","affiliation":[{"name":"Department of Translational Medical Sciences University of Naples Federico II Naples Italy"},{"name":"Research and Development Laboratory GRAF SpA Nonantola (MO) Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Centenaro","sequence":"additional","affiliation":[{"name":"Division of Research and Development Sanypet SpA 35023 Bagnoli di Sopra (PD) Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Giovazzino","sequence":"additional","affiliation":[{"name":"Department of Translational Medical Sciences University of Naples Federico II Naples Italy"},{"name":"Research and Development Laboratory GRAF SpA Nonantola (MO) Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E.","family":"Fraccaroli","sequence":"additional","affiliation":[{"name":"Division of Research and Development Sanypet SpA 35023 Bagnoli di Sopra (PD) Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L.","family":"Cortese","sequence":"additional","affiliation":[{"name":"Department of Veterinary Medicine and Animal Productions University of Naples Federico II Naples Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G.","family":"Ruggiero","sequence":"additional","affiliation":[{"name":"Department of Translational Medical Sciences University of Naples Federico II Naples Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G.","family":"Guidetti","sequence":"additional","affiliation":[{"name":"Division of Research and Development Sanypet SpA 35023 Bagnoli di Sopra (PD) Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Canello","sequence":"additional","affiliation":[{"name":"Division of Research and Development Sanypet SpA 35023 Bagnoli di Sopra (PD) Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G.","family":"Terrazzano","sequence":"additional","affiliation":[{"name":"Department of Translational Medical Sciences University of Naples Federico II Naples Italy"},{"name":"Department of Science University of Basilicata 85100 Potenza Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2015,11,5]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.anai.2014.06.029"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.yexcr.2013.11.012"},{"key":"e_1_2_6_4_1","first-page":"e52717","article-title":"Therapeutic effectiveness of a dietary supplement for management of halitosis in dogs","volume":"101","author":"Di Cerbo A","year":"2015","journal-title":"J Vis Exp"},{"issue":"6","key":"e_1_2_6_5_1","first-page":"1427","article-title":"Antibiotic treatments in zootechnology and effects induced on the food chain of domestic species and, comparatively, the human species","volume":"29","author":"Palmieri B","year":"2014","journal-title":"Nutr Hosp"},{"key":"e_1_2_6_6_1","volume-title":"Maximum residue limits for veterinary drugs in foods","author":"(FAO) FaAO","year":"2012"},{"key":"e_1_2_6_7_1","unstructured":"Agency UEP.Electronic Code of Federal Regulations (eCFR). Title 21: Food and drugs. PART 556d Tolerances for residues of new animal drugs in food. Subpart Bd\u2010specific tolerances for residues of new animal drugs;2014."},{"key":"e_1_2_6_8_1","first-page":"4036","article-title":"EU summary report on antimicrobial resistance in zoonotic and indicator bacteria from humans, animals and food in 2013","volume":"13","author":"Authority EFS","year":"2015","journal-title":"EFSA J"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0091-6749(03)01783-4"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjmed.2009.01.034"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clinthera.2005.09.005"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1097\/00001813-200311000-00001"},{"issue":"2","key":"e_1_2_6_13_1","first-page":"395","article-title":"Unusual antibiotic presence in gym trained subjects with food intolerance; a case report","volume":"30","author":"Di Cerbo A","year":"2014","journal-title":"Nutr Hosp"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1177\/08959374980120012801"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0304-3835(98)00003-2"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1080\/09723757.2011.11886119"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature06246"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM200007063430107"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1183021"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1006\/clin.1996.0118"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.1615\/CritRevImmunol.v25.i2.10"},{"issue":"87","key":"e_1_2_6_22_1","first-page":"123","article-title":"Interferon\u2010gamma and systemic autoimmunity","volume":"16","author":"Pollard KM","year":"2013","journal-title":"Discov Med"},{"key":"e_1_2_6_23_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.0105-2896.2005.00252.x"},{"key":"e_1_2_6_24_1","doi-asserted-by":"publisher","DOI":"10.1620\/tjem.164.259"},{"key":"e_1_2_6_25_1","doi-asserted-by":"publisher","DOI":"10.1089\/jir.2010.0126"},{"key":"e_1_2_6_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2009.09.002"},{"key":"e_1_2_6_27_1","doi-asserted-by":"publisher","DOI":"10.1097\/BOR.0b013e32835c7e32"},{"issue":"10","key":"e_1_2_6_28_1","doi-asserted-by":"crossref","first-page":"5105","DOI":"10.4049\/jimmunol.160.10.5105","article-title":"IFN\u2010gamma\u2010deficient mice develop severe granulomatous experimental autoimmune thyroiditis with eosinophil infiltration in thyroids","volume":"160","author":"Tang H","year":"1998","journal-title":"J Immunol"},{"key":"e_1_2_6_29_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.169.7.3999"},{"key":"e_1_2_6_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.coi.2004.09.014"},{"key":"e_1_2_6_31_1","doi-asserted-by":"publisher","DOI":"10.1159\/000365632"},{"key":"e_1_2_6_32_1","doi-asserted-by":"publisher","DOI":"10.1038\/nri3044"},{"key":"e_1_2_6_33_1","first-page":"400","article-title":"NK cells blur the frontier between innate and acquired immunity","volume":"3","author":"Terrazzano G","year":"2012","journal-title":"Front Immunol"},{"key":"e_1_2_6_34_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2014.00027"},{"key":"e_1_2_6_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2013.07.030"},{"key":"e_1_2_6_36_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.179.1.372"},{"key":"e_1_2_6_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.leukres.2008.03.019"},{"key":"e_1_2_6_38_1","doi-asserted-by":"publisher","DOI":"10.1111\/ejh.12152"},{"key":"e_1_2_6_39_1","doi-asserted-by":"publisher","DOI":"10.1021\/tx9003787"},{"key":"e_1_2_6_40_1","doi-asserted-by":"publisher","DOI":"10.1097\/BOR.0b013e32832f13db"},{"key":"e_1_2_6_41_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00403-008-0895-5"},{"key":"e_1_2_6_42_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tox.2004.12.025"},{"key":"e_1_2_6_43_1","doi-asserted-by":"publisher","DOI":"10.1080\/15476910590960143"},{"key":"e_1_2_6_44_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.autrev.2004.12.005"},{"key":"e_1_2_6_45_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749-6632.2011.06354.x"},{"key":"e_1_2_6_46_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.autrev.2003.10.001"},{"key":"e_1_2_6_47_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10067-013-2245-z"},{"key":"e_1_2_6_48_1","doi-asserted-by":"publisher","DOI":"10.1023\/A:1021144209209"},{"key":"e_1_2_6_49_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1756-185X.2009.01389.x"},{"key":"e_1_2_6_50_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.chemosphere.2006.03.026"},{"key":"e_1_2_6_51_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00244-001-0017-2"},{"key":"e_1_2_6_52_1","doi-asserted-by":"publisher","DOI":"10.1128\/MMBR.65.2.232-260.2001"},{"key":"e_1_2_6_53_1","doi-asserted-by":"publisher","DOI":"10.3382\/ps.0561430"},{"key":"e_1_2_6_54_1","first-page":"1","article-title":"Commission Regulation EU\/37\/2010 on pharmacologically active substances and their classification regarding maximum residue limits in foodstuffs of animal origin","volume":"15","author":"Union E.","year":"2010","journal-title":"J Eur Union"},{"key":"e_1_2_6_55_1","doi-asserted-by":"publisher","DOI":"10.3382\/ps\/pev141"},{"key":"e_1_2_6_56_1","doi-asserted-by":"publisher","DOI":"10.1593\/neo.101152"},{"key":"e_1_2_6_57_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.imbio.2011.11.009"},{"key":"e_1_2_6_58_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(04)00046-7"},{"key":"e_1_2_6_59_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrm2972"},{"issue":"7","key":"e_1_2_6_60_1","doi-asserted-by":"crossref","first-page":"3685","DOI":"10.4049\/jimmunol.152.7.3685","article-title":"Accelerated in vitro apoptosis of lymphocytes from patients with systemic lupus erythematosus","volume":"152","author":"Emlen W","year":"1994","journal-title":"J Immunol"},{"key":"e_1_2_6_61_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00281-006-0038-z"},{"key":"e_1_2_6_62_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.autrev.2010.02.007"},{"key":"e_1_2_6_63_1","doi-asserted-by":"publisher","DOI":"10.1093\/ndt\/17.5.697"},{"issue":"9","key":"e_1_2_6_64_1","doi-asserted-by":"crossref","first-page":"4467","DOI":"10.4049\/jimmunol.161.9.4467","article-title":"Bystander apoptosis triggers dendritic cell maturation and antigen\u2010presenting function","volume":"161","author":"Rovere P","year":"1998","journal-title":"J Immunol"},{"key":"e_1_2_6_65_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-3164.2012.01088.x"},{"key":"e_1_2_6_66_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-3164.2006.00540.x"},{"issue":"12","key":"e_1_2_6_67_1","first-page":"830","article-title":"A survey of canine and feline skin disorders seen in a university practice: Small Animal Clinic, University of Montreal, Saint\u2010Hyacinthe, Quebec (1987\u20101988)","volume":"31","author":"Scott DW","year":"1990","journal-title":"Can Vet J"},{"issue":"10","key":"e_1_2_6_68_1","doi-asserted-by":"crossref","first-page":"1603","DOI":"10.2460\/javma.1992.201.10.1603","article-title":"Idiopathic inflammatory bowel disease in dogs and cats: 84 cases (1987\u20101990)","volume":"201","author":"Jergens AE","year":"1992","journal-title":"J Am Vet Med Assoc"},{"key":"e_1_2_6_69_1","doi-asserted-by":"publisher","DOI":"10.3899\/jrheum.091461"},{"key":"e_1_2_6_70_1","first-page":"3","article-title":"Immune\u2010mediated diseases: where do we stand?","volume":"601","author":"Shurin MR","year":"2007","journal-title":"Adv Exp Med Biol"},{"key":"e_1_2_6_71_1","doi-asserted-by":"publisher","DOI":"10.4102\/ojvr.v82i1.816"},{"key":"e_1_2_6_72_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.prevetmed.2015.05.010"},{"key":"e_1_2_6_73_1","doi-asserted-by":"publisher","DOI":"10.3389\/fmicb.2015.00602"},{"key":"e_1_2_6_74_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jprot.2015.05.040"},{"key":"e_1_2_6_75_1","unstructured":"Authority EFS.EFSA's assistance for the 2015 Codex Committee on Residues of Veterinary Drugs in Food (CCRVDF) in relation to rBST;2015. pp1\u201389."}],"container-title":["Journal of Biochemical and Molecular Toxicology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fjbt.21775","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jbt.21775","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/jbt.21775","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jbt.21775","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,6,12]],"date-time":"2024-06-12T07:14:00Z","timestamp":1718176440000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/jbt.21775"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,11,5]]},"references-count":74,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2016,4]]}},"alternative-id":["10.1002\/jbt.21775"],"URL":"https:\/\/doi.org\/10.1002\/jbt.21775","archive":["Portico"],"relation":{},"ISSN":["1095-6670","1099-0461"],"issn-type":[{"value":"1095-6670","type":"print"},{"value":"1099-0461","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,11,5]]}}}