{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,25]],"date-time":"2026-10-25T19:14:40Z","timestamp":1792955680899,"version":"4.5.0"},"reference-count":29,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2016,3,1]],"date-time":"2016-03-01T00:00:00Z","timestamp":1456790400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Scientific Research Projects Unit of Adiyaman University (ADYUBAP)","award":["FEFYL-2011\/0015"],"award-info":[{"award-number":["FEFYL-2011\/0015"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Biochem &amp; Molecular Tox"],"published-print":{"date-parts":[[2016,5]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Lead has several adverse effects on the body due to one of the environmental pollutants. We aimed to determine the effects of naringenin on the oxidative stress and the hepatic damage against lead acetate treatment in the liver of male rats. Naringenin was administered by orogastric gavage (50 mg\/kg) and lead acetate was given as daily 500 parts per million in drinking water for 4 weeks. Lead and antioxidant activities were measured, and histopathological evaluation was performed in the liver. Lead concentrations, malondialdehyde, and antioxidant activity were restored by the naringenin. The grade of necrosis, hydropic degeneration, and hepatic cord disorganization was decreased by the naringenin. However, there were no differences in the degree of sinusoidal congestion, hepatic steatosis, and capsular fibrosis between lead acetate and naringenin + lead acetate groups. We can suggest that naringenin has antioxidant and chelating effects in the liver. Nevertheless, this effect is not enough against the lead acetate induced hepatic injury.<\/jats:p>","DOI":"10.1002\/jbt.21785","type":"journal-article","created":{"date-parts":[[2016,3,1]],"date-time":"2016-03-01T09:17:28Z","timestamp":1456823848000},"page":"243-248","source":"Crossref","is-referenced-by-count":40,"title":["Effects of Naringenin on Oxidative Stress and Histopathological Changes in the Liver of Lead Acetate Administered Rats"],"prefix":"10.1002","volume":"30","author":[{"given":"Ahmet","family":"Ozkaya","sequence":"first","affiliation":[{"name":"Department of Chemistry, Faculty of Science and Art Adiyaman University Adiyaman 02040 Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zafer","family":"Sahin","sequence":"additional","affiliation":[{"name":"Department of Physiotherapy and Rehabilitation, Faculty of Health Sciences Necmettin Erbakan University Konya 42040 Turkey"},{"name":"Experimental Medicine Research and Application Center (KON\u00dcDAM) of Necmettin Erbakan University Konya 42080 Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Uzeyir","family":"Dag","sequence":"additional","affiliation":[{"name":"Department of Chemistry, Faculty of Science and Art Adiyaman University Adiyaman 02040 Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mustafa","family":"Ozkaraca","sequence":"additional","affiliation":[{"name":"Department of Pathology, Faculty of Veterinary Medicine Ataturk University Erzurum 25240 Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2016,3]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"crossref","first-page":"673","DOI":"10.1016\/S0031-6997(24)01472-8","article-title":"The effects of plant flavonoids on mammalian cells: implications for inflammation, heart disease, and cancer","volume":"52","author":"Middleton E","year":"2000","journal-title":"Pharmacol. 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