{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,9,29]],"date-time":"2023-09-29T07:40:45Z","timestamp":1695973245192},"reference-count":80,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2016,1,13]],"date-time":"2016-01-13T00:00:00Z","timestamp":1452643200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Scientific Research Projects Unit of Siirt University","award":["2013-S\u0130\u00dcFED-F6"],"award-info":[{"award-number":["2013-S\u0130\u00dcFED-F6"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Biochem &amp; Molecular Tox"],"published-print":{"date-parts":[[2016,6]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:p>Inhibitors of carbonic anhydrase (hCA; EC 4.2.1.1) are used as medicines for many diseases. Therefore, they are very important. In this study, a known series of Schiff bases were synthesized and their effects on the activities of hCA\u2010I and hCA\u2010II, which are cytosolic isoenzymes of carbonic anhydrase, were investigated under in vitro conditions. The synthesized compounds (H1, H2, H3, and H4) were found to cause inhibition on enzyme activities of hCA\u20101 and hCA\u2010II. IC<jats:sub>50<\/jats:sub> values of H1, H2, H3, and H4 compounds were 140, 88, 201, and 271 \u03bcM for hCA\u2010I enzyme activity and 134, 251, 79, and 604 \u03bcM for hCA\u2010II enzyme activity, respectively. The synthesized Schiff bases were characterized by several methods, including <jats:sup>1<\/jats:sup>H NMR, FT\u2010IR, elemental analysis, and polarimetric measurements. Correlation coefficient square values (<jats:italic>R<\/jats:italic><jats:sup>2<\/jats:sup>) of comparison of the theoretical and experimental <jats:sup>1<\/jats:sup>H NMR shifts for H1, H2, H3, and H4 compounds were found as 0.9781, 0.9814, 0.9758, and 0.8635, respectively.<\/jats:p>","DOI":"10.1002\/jbt.21788","type":"journal-article","created":{"date-parts":[[2016,1,14]],"date-time":"2016-01-14T08:52:48Z","timestamp":1452761568000},"page":"277-286","source":"Crossref","is-referenced-by-count":1,"title":["Investigation of the Effect of Some Optically Active Imine Compounds on the Enzyme Activities of hCA\u2010I and hCA\u2010II under In Vitro Conditions: An Experimental and Theoretical Study"],"prefix":"10.1002","volume":"30","author":[{"given":"Osman","family":"Tektas","sequence":"first","affiliation":[{"name":"Department of Chemistry, Faculty of Arts and Sciences Siirt University  56100 Siirt 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