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Its use in experimental model could help the understanding of the cellular and molecular mechanisms involved in the neuropathological processes related to potassium channel dysfunctions. In this study, the ability of KTX to stimulate neuro\u2010immuno\u2010endocrine axis was investigated. As results, the intracerebroventricular injection of KTX leads to severe structural\u2013functional alterations of both hypothalamus and thyroid. These alterations were characterized by a massive release of hormones\u2019 markers of thyroid function associated with damaged tissue which was infiltrated by inflammatory cell and an imbalanced redox status. Taken together, these data highlight that KTX is able to modulate the neuro\u2010endocrine response after binding to its targets leading to the hypothalamus and the thyroid stimulation, probably by inflammatory response activation and the installation of oxidative stress in these organs.<\/jats:p>","DOI":"10.1002\/jbt.21824","type":"journal-article","created":{"date-parts":[[2016,6,7]],"date-time":"2016-06-07T10:29:53Z","timestamp":1465295393000},"page":"580-587","source":"Crossref","is-referenced-by-count":4,"title":["Neuro\u2010Modulation of Immuno\u2010Endocrine Response Induced by Kaliotoxin of<i>Androctonus<\/i>Scorpion Venom"],"prefix":"10.1002","volume":"30","author":[{"given":"Amina","family":"Ladjel\u2010Mendil","sequence":"first","affiliation":[{"name":"USTHB, Laboratory of Cellular and Molecular Biology, Faculty of Biological Sciences University of Sciences and Technology Houari Boumediene Algiers Algeria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marie\u2010France","family":"Martin\u2010Eauclaire","sequence":"additional","affiliation":[{"name":"CNRS UMR 7286 CRN2M, Institut F\u00e9d\u00e9ratif de Recherche Jean Roche, Facult\u00e9 de M\u00e9decine Nord Aix\u2010Marseille University Marseille France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fatima","family":"Laraba\u2010Djebari","sequence":"additional","affiliation":[{"name":"USTHB, Laboratory of Cellular and Molecular Biology, Faculty of Biological Sciences University of Sciences and Technology Houari Boumediene Algiers Algeria"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2016,6,7]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1432-1033.1972.tb01924.x"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/0041-0101(84)90153-3"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/nt.2620010510"},{"issue":"52","key":"e_1_2_5_5_1","doi-asserted-by":"crossref","first-page":"32835","DOI":"10.1016\/S0021-9258(20)30067-3","article-title":"The kaliotoxin family enlarged. 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