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It has been seen that cholestasis is associated with hypercholesterolemia, which is a prerequisite for gallstone formation and primary biliary cirrhosis, being some of the most common gastrointestinal disorders in Western societies. Cytotoxic BAs induce proinflammatory mediators, oxidative stress, and apoptosis in hepatocytes, whereas cytoprotective BAs prevent them; they can also modify the plasmatic membrane structure of cells or mitochondrial outer membrane properties as well as the distribution of cholesterol, altering various proteins involved in BAs homeostasis.<\/jats:p>","DOI":"10.1002\/jbt.21831","type":"journal-article","created":{"date-parts":[[2016,8,12]],"date-time":"2016-08-12T15:44:38Z","timestamp":1471016678000},"page":"1-6","source":"Crossref","is-referenced-by-count":9,"title":["Elevated cholesterol levels have a poor prognosis in a cholestasis scenario"],"prefix":"10.1002","volume":"31","author":[{"given":"Natalia","family":"Nu\u00f1o\u2010L\u00e1mbarri","sequence":"first","affiliation":[{"name":"Traslational Research Unit M\u00e9dica Sur Clinic &amp; Foundation  Toriello guerra tlalpan, C.P. 14050 Mexico City Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Varenka J","family":"Barbero\u2010Becerra","sequence":"additional","affiliation":[{"name":"Traslational Research Unit M\u00e9dica Sur Clinic &amp; Foundation  Toriello guerra tlalpan, C.P. 14050 Mexico City Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Misael","family":"Uribe","sequence":"additional","affiliation":[{"name":"Obesity and Digestive Diseases Unit M\u00e9dica Sur Clinic &amp; Foundation  Toriello guerra tlalpan, C.P. 14050 Mexico City Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Norberto C","family":"Ch\u00e1vez\u2010Tapia","sequence":"additional","affiliation":[{"name":"Traslational Research Unit M\u00e9dica Sur Clinic &amp; Foundation  Toriello guerra tlalpan, C.P. 14050 Mexico City Mexico"},{"name":"Obesity and Digestive Diseases Unit M\u00e9dica Sur Clinic &amp; Foundation  Toriello guerra tlalpan, C.P. 14050 Mexico City Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2016,8,12]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2011.09.051"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0168-8278(00)80421-3"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajpath.2010.11.026"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.21763"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-230X-12-20"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1161\/ATVBAHA.113.302355"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2006.07.006"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2012.05.019"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10620-015-3776-8"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbamem.2013.05.021"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1478-3231.2011.02662.x"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v18.i36.4985"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1159\/000324141"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.5604\/16652681.1171785"},{"key":"e_1_2_8_16_1","first-page":"2079","volume":"59","author":"Yazgan Y.","year":"2012","journal-title":"Hepatogastroenterology"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI3597"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2007.07.005"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1177\/2040622315605821"},{"key":"e_1_2_8_20_1","first-page":"4931","volume":"11","author":"Marra F.","year":"2005","journal-title":"World J. 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