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The objective of present study is to find out the cardioprotective activity and to explore the underlying mechanisms of quercetin pretreatment (50 mg\/kg body weight, orally) for 14 days against isoproterenol (ISO; 100 mg\/kg body weight, subcutaneously) induced myocardial infarction in Wistar rats. Cardiac diagnostic markers, oxidative stress, inflammatory cytokines, histopathology along with gene expression analysis of calpain 1 and 2 were carried out in experimental rats. Quercetin pretreatment showed protective effects on heart by significantly attenuating the ISO\u2010induced oxidative stress, inflammation, protecting heart architecture, and by downregulation of the expression of calpain. Overall, these findings revealed the cardio\u2010protective potential of quercetin and its mechanism of action against ISO\u2010induced MI in rats.<\/jats:p>","DOI":"10.1002\/jbt.21832","type":"journal-article","created":{"date-parts":[[2016,8,16]],"date-time":"2016-08-16T04:26:41Z","timestamp":1471321601000},"page":"1-8","source":"Crossref","is-referenced-by-count":50,"title":["Molecular and biochemical evidence on the protective effects of quercetin in isoproterenol\u2010induced acute myocardial injury in rats"],"prefix":"10.1002","volume":"31","author":[{"given":"Mukesh","family":"Kumar","sequence":"first","affiliation":[{"name":"Department of Pharmacology &amp; Toxicology National Institute of Pharmaceutical Education and Research  Guwahati 781 032 Assam India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eshvendar Reddy","family":"Kasala","sequence":"additional","affiliation":[{"name":"Department of Pharmacology &amp; Toxicology National Institute of Pharmaceutical Education and Research  Guwahati 781 032 Assam India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lakshmi Narendra","family":"Bodduluru","sequence":"additional","affiliation":[{"name":"Department of Pharmacology &amp; Toxicology National Institute of Pharmaceutical Education and Research  Guwahati 781 032 Assam India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vikas","family":"Kumar","sequence":"additional","affiliation":[{"name":"Neuropharmacology Research Laboratory, Department of Pharmaceutics Indian Institute of Technology (Banaras Hindu University)  Varanasi 221 005 Uttar Pradesh India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mangala","family":"Lahkar","sequence":"additional","affiliation":[{"name":"Department of Pharmacology &amp; Toxicology National Institute of Pharmaceutical Education and Research  Guwahati 781 032 Assam India"},{"name":"Department of Pharmacology Gauhati Medical College  Guwahati 781 032 India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2016,8,15]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.yjmcc.2010.02.024"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1515\/bchm.2001.382.5.743"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0304-3940(98)00219-5"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cardiores.2004.06.001"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.immunol.16.1.395"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejphar.2011.02.037"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejphar.2011.09.036"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00011-016-0944-z"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.ejcn.1601624"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1080\/01635589309514267"},{"key":"e_1_2_6_12_1","doi-asserted-by":"crossref","first-page":"950","DOI":"10.1093\/jaoac\/83.4.950","volume":"83","author":"Prior R. 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