{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,31]],"date-time":"2026-07-31T20:32:42Z","timestamp":1785529962848,"version":"3.56.0"},"reference-count":37,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2016,10,20]],"date-time":"2016-10-20T00:00:00Z","timestamp":1476921600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Biochem &amp; Molecular Tox"],"published-print":{"date-parts":[[2017,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Vardenafil is a selective phosphodiesterase\u20105 inhibitor used for erectile dysfunction treatment. The hepatoprotective role of vardenafil against acute hepatitis is not reported yet. Hence, this study aims to explore the protective role of vardenafil against concanavalin A (Con A) induced acute liver injury. Mice were pretreated with vardenafil (0.17 mg\/kg\/day) for seven consecutive days, and then subjected to a single IV injection of Con A. The results demonstrated that the vardenafil pretreatment significantly reduced the elevated serum levels of transaminases and alkaline phosphatase. Histopathological examination showed marked necrosis and inflammation in Con A\u2013treated mice which was significantly ameliorated in vardenafil pretreated animals. Vardenafil pretreatment significantly alleviated the expression of nuclear factor kappa\u2010B and inducible nitric oxide synthase in the hepatic tissue. Additionally, serum levels of nitric oxide and tumor necrosis factor\u2010alpha were decreased in vardenafil pretreated animals compared to the Con A group. Therefore, our results demonstrate that vardenafil has hepatoprotective effect and this could be linked to decrease inflammatory mediators.<\/jats:p>","DOI":"10.1002\/jbt.21867","type":"journal-article","created":{"date-parts":[[2016,10,20]],"date-time":"2016-10-20T11:07:11Z","timestamp":1476961631000},"source":"Crossref","is-referenced-by-count":3,"title":["Hepatoprotective role of vardenafil against experimentally induced hepatitis in mice"],"prefix":"10.1002","volume":"31","author":[{"given":"Nishat","family":"Ahmed","sequence":"first","affiliation":[{"name":"Pharmacology and Toxicology \u00a0Department, College of Pharmacy Taibah University  Almadinah Almunawwarah 30001 Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nada F.","family":"Bakhashwain","sequence":"additional","affiliation":[{"name":"Pharm D Department, College of Pharmacy Taibah University  Almadinah \u00a0Almunawwarah 30001 Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alaa F.","family":"Alsehemi","sequence":"additional","affiliation":[{"name":"Pharm D Department, College of Pharmacy Taibah University  Almadinah \u00a0Almunawwarah 30001 Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dina S.","family":"El\u2010Agamy","sequence":"additional","affiliation":[{"name":"Pharmacology and Toxicology \u00a0Department, College of Pharmacy Taibah University  Almadinah Almunawwarah 30001 Saudi Arabia"},{"name":"Pharmacology and Toxicology Department, Faculty of Pharmacy Mansoura University  Mansoura 35516 Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2016,10,20]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v18.i2.119"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpgi.00522.2005"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1572-0241.2000.01979.x"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/9780470516751.ch14"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI115836"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1053\/jhep.2000.17701"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11010-011-0920-4"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0087977"},{"key":"e_1_2_7_10_1","doi-asserted-by":"crossref","first-page":"e231","DOI":"10.1111\/j.1440-1746.2007.05083.x","volume":"23","author":"Xue\u2010Lian M.","year":"2008","journal-title":"J. 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