{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T11:41:56Z","timestamp":1789558916533,"version":"build-2803163510"},"reference-count":32,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2016,11,23]],"date-time":"2016-11-23T00:00:00Z","timestamp":1479859200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["U1432124"],"award-info":[{"award-number":["U1432124"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Biochem &amp; Molecular Tox"],"published-print":{"date-parts":[[2017,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The skin\u2010associated chemokine CCL27 and its receptor CCR10 mediate the immune response of skin\u2010homing T cells. The CCL27 secreted from keratinocytes was reportedly involved in inflammatory skin diseases such as atopic dermatitis, contact dermatitis, and psoriasis. However, whether ionizing radiation increases the levels of CCL27 secretion still remains unclear. In HaCaT cells, a human keratinocyte cell line, CCL27 secretion was markedly increased after X\u2010ray irradiation. We further found that irradiation boosted the generation of reactive oxygen species (ROS), which was concomitant with the release of tumor necrosis factor\u2010alpha (TNF\u2010\u03b1). Moreover, alteration of ROS in irradiated HaCaT cells correlated with TNF\u2010\u03b1 secretion, indicating a positive loop of TNF\u2010\u03b1 secretion and ROS generation. This positive loop regulated the secretion of CCL27 from irradiated cells. We therefore concluded that the cross talk between TNF\u2010\u03b1 and ROS after keratinocytes was exposed to radiation, triggered CCL27 secretion for subsequent inflammation response.<\/jats:p>","DOI":"10.1002\/jbt.21868","type":"journal-article","created":{"date-parts":[[2016,11,23]],"date-time":"2016-11-23T14:52:22Z","timestamp":1479912742000},"source":"Crossref","is-referenced-by-count":19,"title":["Ionizing radiation promotes CCL27 secretion from keratinocytes through the cross talk between TNF\u2010\u03b1 and ROS"],"prefix":"10.1002","volume":"31","author":[{"given":"Qian","family":"Zhang","sequence":"first","affiliation":[{"name":"Teaching &amp; Research Section of Nuclear Medicine Anhui Medical University  Hefei Anhui 230032 People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Linlin","family":"Zhu","sequence":"additional","affiliation":[{"name":"Teaching &amp; Research Section of Nuclear Medicine Anhui Medical University  Hefei Anhui 230032 People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gang","family":"Wang","sequence":"additional","affiliation":[{"name":"Teaching &amp; Research Section of Nuclear Medicine Anhui Medical University  Hefei Anhui 230032 People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ye","family":"Zhao","sequence":"additional","affiliation":[{"name":"Teaching &amp; Research Section of Nuclear Medicine Anhui Medical University  Hefei Anhui 230032 People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Na","family":"Xiong","sequence":"additional","affiliation":[{"name":"Teaching &amp; Research Section of Nuclear Medicine Anhui Medical University  Hefei Anhui 230032 People's Republic of China"},{"name":"Center for Molecular Immunology and Infectious Disease, Department of Veterinary and Biomedical Sciences The Pennsylvania State University  University Park PA 16802 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hegang","family":"Bao","sequence":"additional","affiliation":[{"name":"Teaching &amp; Research Section of Nuclear Medicine Anhui Medical University  Hefei Anhui 230032 People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wensen","family":"Jin","sequence":"additional","affiliation":[{"name":"Teaching &amp; Research Section of Nuclear Medicine Anhui Medical University  Hefei Anhui 230032 People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2016,11,23]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1667\/RR13578.1"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1667\/RR2861.1"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2407-14-53"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1177\/1534735413490235"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13671-013-0063-9"},{"key":"e_1_2_6_7_1","first-page":"618","volume":"39","author":"Park L. 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