{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,5]],"date-time":"2026-06-05T05:53:41Z","timestamp":1780638821660,"version":"3.54.1"},"reference-count":40,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2017,2,10]],"date-time":"2017-02-10T00:00:00Z","timestamp":1486684800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["31171123, 31471120"],"award-info":[{"award-number":["31171123, 31471120"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["31540076"],"award-info":[{"award-number":["31540076"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["31300850"],"award-info":[{"award-number":["31300850"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["31571126"],"award-info":[{"award-number":["31571126"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004602","name":"Program for New Century Excellent Talents in University","doi-asserted-by":"publisher","award":["NCET\u201013\u20100715"],"award-info":[{"award-number":["NCET\u201013\u20100715"]}],"id":[{"id":"10.13039\/501100004602","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Biochem &amp; Molecular Tox"],"published-print":{"date-parts":[[2017,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Corticosterone plays an important role in feeding behavior. However, its mechanism remains unclear. Therefore, the present study aimed to investigate the effect of corticosterone on feeding behavior. In this study, cumulative food intake was increased by acute corticosterone administration in a dose\u2010dependent manner. Administration of the 5\u2010HT<jats:sub>2c<\/jats:sub> receptor agonist m\u2010chlorophenylpiperazin (mCPP) reversed the effect of corticosterone on food intake. The anorectic effects of mCPP were also blocked by the 5\u2010HT<jats:sub>2c<\/jats:sub> receptor antagonist RS102221 in corticosterone\u2010treated mice. Both corticosterone and mCPP increased c\u2010Fos expression in hypothalamic nuclei, but not the nucleus of the solitary tract. RS102221 inhibited c\u2010Fos expression induced by mCPP, but not corticosterone. In addition, mCPP had little effect on TH and POMC levels in the hypothalamus. Furthermore, mCPP antagonized decreasing effect of the leptin produced by corticosterone. Taken together, our findings suggest that 5\u2010HT<jats:sub>2c<\/jats:sub> receptors and leptin may be involved in the effects of corticosterone\u2010induced hyperphagia.<\/jats:p>","DOI":"10.1002\/jbt.21890","type":"journal-article","created":{"date-parts":[[2017,2,10]],"date-time":"2017-02-10T13:26:43Z","timestamp":1486733203000},"source":"Crossref","is-referenced-by-count":8,"title":["The role of 5\u2010HT<sub>2c<\/sub> receptor on corticosterone\u2010mediated food intake"],"prefix":"10.1002","volume":"31","author":[{"given":"Tongtong","family":"Ge","sequence":"first","affiliation":[{"name":"Jilin Provincial Key Laboratory on Molecular and Chemical Genetics The Second Hospital of Jilin University  Changchun Jilin 130041 People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhuo","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Orthopedics China\u2010Japan Union Hospital of Jilin University 126 Xiantai Street  Nanguan District Changchun 13033 People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiayin","family":"Lv","sequence":"additional","affiliation":[{"name":"Department of Orthopedics China\u2010Japan Union Hospital of Jilin University 126 Xiantai Street  Nanguan District Changchun 13033 People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yunong","family":"Song","sequence":"additional","affiliation":[{"name":"Jilin Provincial Key Laboratory on Molecular and Chemical Genetics The Second Hospital of Jilin University  Changchun Jilin 130041 People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jie","family":"Fan","sequence":"additional","affiliation":[{"name":"Jilin Provincial Key Laboratory on Molecular and Chemical Genetics The Second Hospital of Jilin University  Changchun Jilin 130041 People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Liu","sequence":"additional","affiliation":[{"name":"Jilin Provincial Key Laboratory on Molecular and Chemical Genetics The Second Hospital of Jilin University  Changchun Jilin 130041 People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xuefeng","family":"Wang","sequence":"additional","affiliation":[{"name":"Jilin Provincial Key Laboratory on Molecular and Chemical Genetics The Second Hospital of Jilin University  Changchun Jilin 130041 People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F. Scott","family":"Hall","sequence":"additional","affiliation":[{"name":"Department of Pharmacology and Experimental Therapeutics University of Toledo College of Pharmacy and Pharmaceutical Sciences  Toledo OH USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bingjin","family":"Li","sequence":"additional","affiliation":[{"name":"Jilin Provincial Key Laboratory on Molecular and Chemical Genetics The Second Hospital of Jilin University  Changchun Jilin 130041 People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ranji","family":"Cui","sequence":"additional","affiliation":[{"name":"Jilin Provincial Key Laboratory on Molecular and Chemical Genetics The Second Hospital of Jilin University  Changchun Jilin 130041 People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2017,2,10]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1210\/endo-97-2-265"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejphar.2007.09.037"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1080\/00071669508417794"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1080\/00071669987296"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.0953-8194.2004.01168.x"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1210\/endo.139.9.6287"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.physbeh.2011.07.012"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.1051\/jbio\/2004198010037"},{"key":"e_1_2_5_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.appet.2009.12.015"},{"key":"e_1_2_5_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pbb.2003.10.011"},{"key":"e_1_2_5_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/0304-3940(96)12613-6"},{"key":"e_1_2_5_13_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF02246645"},{"key":"e_1_2_5_14_1","doi-asserted-by":"publisher","DOI":"10.1007\/s002130050952"},{"key":"e_1_2_5_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/0031-9384(92)90384-E"},{"key":"e_1_2_5_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0091-3057(97)00315-8"},{"key":"e_1_2_5_17_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnins.2014.00106"},{"key":"e_1_2_5_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbr.2014.08.065"},{"key":"e_1_2_5_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.psyneuen.2014.03.018"},{"key":"e_1_2_5_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainres.2006.05.058"},{"key":"e_1_2_5_21_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0121473"},{"key":"e_1_2_5_22_1","doi-asserted-by":"publisher","DOI":"10.1093\/jn\/133.2.504"},{"key":"e_1_2_5_23_1","doi-asserted-by":"publisher","DOI":"10.1210\/endo.140.12.7288"},{"key":"e_1_2_5_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbi.2004.11.004"},{"key":"e_1_2_5_25_1","doi-asserted-by":"publisher","DOI":"10.1210\/en.2004-0305"},{"key":"e_1_2_5_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/0006-8993(89)91639-9"},{"key":"e_1_2_5_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbr.2008.07.039"},{"key":"e_1_2_5_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neulet.2009.12.006"},{"key":"e_1_2_5_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.yfrne.2003.07.001"},{"key":"e_1_2_5_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0896-6273(00)81084-3"},{"key":"e_1_2_5_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/0031-9384(87)90254-X"},{"key":"e_1_2_5_32_1","first-page":"751","volume":"256","author":"Arase K.","year":"1989","journal-title":"Am. J. Physiol."},{"key":"e_1_2_5_33_1","first-page":"1623","volume":"266","author":"Thomas T. L.","year":"1994","journal-title":"Am. J. Physiol."},{"key":"e_1_2_5_34_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00213-003-1735-0"},{"key":"e_1_2_5_35_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.19-14-06111.1999"},{"key":"e_1_2_5_36_1","first-page":"239","volume":"5","author":"Losada M. E. O.","year":"1998","journal-title":"Biog. Amines"},{"key":"e_1_2_5_37_1","doi-asserted-by":"publisher","DOI":"10.1006\/hbeh.2001.1646"},{"key":"e_1_2_5_38_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1476-5381.2009.00406.x"},{"key":"e_1_2_5_39_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF02245142"},{"issue":"4","key":"e_1_2_5_40_1","doi-asserted-by":"crossref","first-page":"717","DOI":"10.2337\/diab.46.4.717","volume":"46","author":"Zakrzewska K. E.","year":"1997","journal-title":"Diabetes"},{"key":"e_1_2_5_41_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0091-3057(03)00030-3"}],"container-title":["Journal of Biochemical and Molecular Toxicology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fjbt.21890","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jbt.21890","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,4]],"date-time":"2023-10-04T02:45:14Z","timestamp":1696387514000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/jbt.21890"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,2,10]]},"references-count":40,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2017,6]]}},"alternative-id":["10.1002\/jbt.21890"],"URL":"https:\/\/doi.org\/10.1002\/jbt.21890","archive":["Portico"],"relation":{},"ISSN":["1095-6670","1099-0461"],"issn-type":[{"value":"1095-6670","type":"print"},{"value":"1099-0461","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,2,10]]},"article-number":"e21890"}}